تغییرات ایمونولوژیک در مردان سالم سیگاری

Background: The main function of the immune system is to defence against infections and killing the tumor cells. It has been reported that smoking reduces the resistance to infections and increases the incidence of cancers. The aim of this study was to assess selected indices of immunity, inhealthy  cigarette smoker men. Materials and Methods: Blood samples were collected from 68 healthy men, including, 32 subjects smoking for more than 5 years (case group), and 36 aged-matched men who never used to smoke (control group). The following parameters were studiedand compared in two groups: total and differential white blood cell (WBC) counts, serum concentration of immunoglobulins including: IgG, IgA, IgM and IgE, C3 and C4 complement components. Results: Decreased serum concentration of IgG, IgM and, IgA observed in smoker men compared to nonsmokers. Smokers had higher IgE concentration than non-smokers (522 IU/ml Vs 381 IU/ml P<0.01). In smokers, the absolute count of circulating WBC, PMN cells and lymphocytes was significantly higher than those in nonsmokers. Conclusion: These results indicated that several significant immunological alterations were occurred in smoker men, compare to nonsmoker. Keywords: Cigarette smoking, Immunoglobulins, White blood cells count, Men. Corres ponding author,tell: (391)8220084 Journal of Rafsanjan University of Health and Medical Sciences 2002 1(4):