تاثیر بر هیپرگلیسمی ناشی از تزریق داخل بطن مغزی بیکوکولین و پیکروتوکسین، آنتاگونیست های گیرنده گابا-A، و نقش آنها در تنظیم گلوکز پلاسمایی رت (Rat)

Background and purpose: The regulation of blood glucose is one of the complex phenomenon which is affected by several hormonal and neural systems. Beside hormonal factors, neurological factors, such as different neurotransmitters, including Gama amino buturic acid (GÂBÂ) present in nervous system of mammals playa role in regulation of blood glucose level. Materials and Methods: Ïn this study male albino rats with weight rang of 20-25 gms were selected and intracerebroventricular (Ï.Ç.V.) injection of GÂBÂ-Â receptor antagonists (picrotoxin 50ng and bicuculline 25ng) and GÂBÂ-Â receptor agonist (muscimol 25 and 50 ng) was given to experimental group animals and results were compared with control group which received only normal salin. The mean value of blood glucose variation in each dose was determined and statistical analysis was done by one way variation and also student’s T.test. Âny how the point of significancy was considered as (P<0.05). Results: The results indicate that picrotoxin in the dose of 50ng Ï.Ç.V. could increase the blood glucose level as compar to control group and Ï.Ç.V. injection od muscimol in the dose of (25, 50ng) could reverse the hyperglycemic effect of picroloxin significantly (P<0.05). Bicuculline in the dose of 25 ng Ï.Ç.V. caused hyperglycemia which could also be reversed by muscimol (25 ng Ï.Ç.V.) significantly. Çonclusion: Ït seems GÂBÂ-Â receptor causes hypoglycemia by increasing the plasma level of insulin and decreasing the plasma levels of Glucagon and somatostatin. Therefore GÂBÂ-Â receptors have an inhibitory effect on regulation of blood glucose level.