بررسی فراوانی نفروپاتی ناشی از ویروس BK در نمونه های بیوپسی

  A Ghafari Moghaddam [1] , MD M Taghizadieh [2] , MD N Aghakhani [3] , MD N Ebrahimi [4] , MD E Rahimi [5] , MDM Ghasemi-rad [6] , MD, S Zafarshams pour [7] , MD    Received: 29 April, 2007 Accepted: 29 Oct, 2008 Abstract  Background &Aims: BK virus nephropathy is recognized as a cause of graft loss in renal transplant patients. The disorder may be related to the introduction of new, potent immunosuppressive regimens. We sought to assess the prevalence, outcome, and clinical characteristics of BK virus nephropathy.   Materials & Methods: We retrospectively analyzed 160 specimens from episode biopsies. BK virus nephropathy was diagnosed by light microscopic examination and positive immunohistochemical staining.   Results : Among 160 patients, 21 (13.1%) were diagnosed as BK virus nephropathy. The mean interval between biopsy and transplantation was 13.6 +/- 10.67 months. There were no significant differences between BK virus nephropathy patients and non-BKVN patients with respect to age, sex, interval between diagnosis and transplantation, cyclosporine blood level, and azathioprine versus mycophenolate mofetil immunosuppression. Graft loss occurred in 57.1% of BK virus nephropathy versus 12.2% of non- BK virus nephropathy subjects (P = .005). There was a significant difference between antilymphocyte globulin (ALG) - and non-ALG-treated groups with respect to the incidence of BKVN (6.6% in non-ALG versus 19% in ALG groups P < .01). BKVN was diagnosed by immunohistochemistry in 61% of specimens with acute rejection according to light microscopic evaluation.   Conclusion : This is the first report of BKVN in Iranian renal allograft recipients. In our hospital, the prevalence of BKVN was higher than that previously reported for non-Iranian recipients. BKVN had a negative impact on graft survival .   Keywords: Renal transplantation, BK virus, Immunosuppressive    Address: Nephrology Department, Imam Khomeini Hospital, Urmia, Iran Tel: 0441-3469931     E-mail: [email protected]     Source: UMJ 2009: 19(4): 363 ISSN: 1027-3727   [1] Assistant Professor of Nephrology, Urmia University of Medical Sciences, Urmia, Iran (Corresponding Author)  [2] Assistant Professor of Pathology, Urmia University of Medical Sciences, Urmia, Iran  [3] General Practitioner, Urmia University of Medical Sciences, Urmia, Iran  [4] General Practitioner, Urmia University of Medical Sciences, Urmia, Iran  [5] Resident of Internal Medicine, Urmia University of Medical Sciences, Urmia, Iran  [6] Medical Student, Urmia University of Medical Sciences, Urmia, Iran  [7] Medical Student, Urmia University of Medical Sciences, Urmia, Iran