بررسی عوارض داروهای ضد التهابی غیر استروئیدی در بیماران آلوده به هلیکوباکترپیلوری و افراد غیر آلوده

   Background : Controversies exist regarding the role of helicobacter pylori infection in NSAIDs-induced GI bleeding. Thus, the present study was conducted to compare the frequency, risk factors and signs and symptoms of NSAIDs-induced GI bleeding among infected and non-infected subjects with H. pylori. Materials and methods : In a cross sectional study, all 256 cases of GI bleeding following NSAIDs usage were enrolled. They undertook endoscopy. H. pylori infection was evaluated by urease test. Results : The study population included 94 males and 162 female with the mean (±SD) age of 55.3±10.9 years. Among these, 190 had positive urease test and the remaining 66 were negative (p<0.05). Female gender, smoking, and alcohol consumption were significantly more common among H pylori-infected individuals. Conclusion : Our study revealed that H pylori infection is common in patients who develop NSAIDs-induced gastro-intestinal bleeding and may increase the risk of bleeding following NSAIDs usage.