بررسی تاثیر نانو ساختار دندریمر پلی پروپیلن ایمین بر خاصیت ضد میکروبی کالای پنبه‌ای

Abstract Background: Cotton fabric which is widely used in hospital clothing and healthcare textiles, is known to be susceptible to microbial contamination. It is logical to think that the poly (propylene imine) (PPI) dendrimers (through their inherent cationic nature) with a large number of terminal primary amino groups, may have antimicrobial activity. This study was conducted to investigate the effect of PPI dendrimer on the antimicrobial property of cotton fabric. Methods: This experimental study was done on two generations of the PPI dendrimers (G2- and G5-PPI-NH2) which were grafted on cotton fabric using cross linking agents (Citric and Glutaric acids). Antimicrobial activity of 1 control (untreated sample) and 2 experimental (treated and grafted samples with the PPI dendrimers) groups was evaluated by zone of inhibition method against three types of bacteria (Staphylococcus aureus, Pseudomona aeruginosa and Escherichia coli) and a fungus (Candida albicans) according to the PN-EN ISO 20645:2007 standard (before and after 5 washing cycles). Results: In the control group, (untreated sample), the microorganisms grew underneath and around edges of the sample. In the second experimental group (treated samples with PPI dendrimers) the microorganisms did not grow underneath and around edges of the sample, but zone of inhibition of the samples was decreased after 5 washing cycles. In third experimental group (grafted samples with PPI dendrimers) the microorganisms did not grow underneath the grafted samples even after 5 washing cycles. Conclusion: It seems that the grafted cotton fabric with the PPI dendrimers has excellent antimicrobial property against the applied microorganisms even after repeated washing cycles. KEYWORDS: Poly (propylene imine) dendrimer, Antimicrobial property, Staphylococcus aureus, Pseudomonades aeruginosa, Escherichia coli, Candida albicans.