بررسی اثرات سیتوتوکسیک هورمون تیروئیدی 4T بر سلول‌های گلایو بلاستومای مغزی (172A) در محیط کشت سلولی

Background: Studies showed thyroid hormones influence proliferation of cancer cells. The main aim of this study was to investigate the effects of cytotoxic thyroid hormone T4 on proliferation of brain glioblastoma cells (A172) in cell culture. Methods: In this laboratory experimental study, A172 cells were randomly divided into control group and groups exposed to doses 0.1, 0.5, 1, 5, 10, 20, 40, 50 Lambda (λ) of thyroid hormone T4. The toxic effect of hormones was measured using MTT assay method. The data were statistically analyzed between groups using ANOVA. Results: The result demonstrated that highest toxicity of thyroid hormone T4 on glioblastoma cancer cells A172 was in 1 lambda (λ) dosage and low toxicity in 0.1 and 40 lambdas (λ) dosages. Conclusion: Toxicity of Glioblastoma cancer cells is either hormone dependent or hormone independent.