ارزیابی خواص ضدالتهابی مشتقات پارا- متیل سولفونیل- 3 و 4-دی آریل -4- تیازولین-2- تیون‌ها به روش کاراژینان در موش سوری

Background and purpose: Cyclooxygenase II enzyme is one of the most important enzymes of prostaglandin synthesis pathway that also causes inflammations in human body. In the present study, the anti-inflammatory activity of eight new synthesized compounds with COX II inhibitory potential was evaluated in carrageenan induced paw edema in mice. Material and methods: Different doses of the compounds (10, 25 and 50 mg/kg), celecoxib (positive control, 10 mg/kg) and normal saline-tween (negative control) were intraperitoneally administered to the mice (female, 25-30 g, n=6). After 30 min, carrageenan was injected subcutaneously into the subplantar tissue of the left paw in all groups. The volume of paw was measured in different treatment groups at 0, 1, 3 and 5 hours following the carrageenan injection and percentage changes of paw volume was calculated. Data were reported as Mean ± SD. T-test was used to compare the results and P < 0.05 was considered significant. Results: At the 10 mg/kg dose, all compounds showed significant anti-inflammatory activity just in 1st hour. At the 25 mg/kg dose, some compounds had significant anti-inflammatory activity in all investigated times, and at 50 mg/kg dose, all compounds showed significant anti-inflammatory activity in 1st , 3rd and 5th hour compared to the group injected with normal saline- tween. Conclusion: This study found 4-(4-Methylsulfonylphenyl)-3-phenyl-2(3H)-thiazole thione derivatives with good anti-inflammatory activities.