Hedayat Sahraei

PhD Professor in neuroscience, Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

[ 1 ] - The Effect of Aromatherapy with Lavender Essential Oil on Depression, Anxiety and Stress in Hemodialysis Patients: A Clinical Trial

Background: Depression, anxiety and stress are common among hemodialysis patients affecting their mental health and quality of life, leading to multiple dysfunctions. Anti-anxiety effects of aromatherapy, as one of the domains of complementary medicine, have been investigated in several studies. Aim: Investigation of the effect of aromatherapy with lavender essential oil on depression, anxiety ...

[ 2 ] - تاثیر تغذیه متناوب بر علایم متابولیکی استرس مزمن در موش کوچک آزمایشگاهی ماده نژاد NMRI

زمینه: کاهش کالری دریافتی می‌تواند به بهبود فعالیت دستگاه عصبی منجر شود. اما تاکنون اثر کاهش کالری ورودی بر فعالیت محور هیپوتالاموس- هیپوفیز- آدرنال که مهم‌ترین محور مغزی- اندوکرینی پاسخ‌دهی به استرس است مورد مطالعه قرار نگرفته است. در این تحقیق اثر کاهش کالری ورودی (تغذیه متناوب) بر علائم متابولیکی استرس را مورد بررسی قرار دادیم. مواد و روش‌ها: موش‌های کوچک آزمایشگاهی ماده با میانگین وزنی 3±27...

[ 3 ] - تاثیر چای (Camellia thea Lk.) بر تسریع اثربخشی استامینوفن در کاهش سردرد

مقدمه: سردرد از شایع‌ترین انواع درد در بیماران است. برای تسکین سردرد، متخصصان داروهای مختلف شیمیایی و غیر‌شیمیایی را به بیماران توصیه کرده‌اند. استامینوفن یکی از انواع رایج داروهایی است که برای بهبود سردرد استفاده می‌شود. از سوی دیگر، چای رایج‌ترین نوشیدنی در دنیا به شمار می‌رود. تحقیقات قبلی نشان داده‌اند که آلکالوییدهای موجود در چای می‌توانند متابولیسم استامینوفن را کاهش دهند. هدف: این تحق...

[ 4 ] - Effect of Aqueous Extract of Trigonella foenum-graecum on Pain and Inflammation Induced by Formalin in Male Mice

Background: Studies have emphasized the effect of Trigonella foenum-graecum extract on the reduction of pain and inflammation. Objective: In this research we investigated the mechanisms of Trigonella foenum-graecum extract in reducing pain and inflammation induced by formalin. Methods: Male Albino mice (weight 20 - 25 g) were evaluated through the injection of 2 microliters of formalin to th...

[ 5 ] - بررسی اثر عصاره گیاه شقایق (Papaver rhoeas L.) بر کسب و بیان ترجیح مکان شرطی شده ناشی از مورفین در موش‌های کوچک آزمایشگاهی نر

هدف: در تحقیق حاضر، اثر عصاره آبی الکلی گیاه شقایق Papaver rhoeasبر کسب و بیان ترجیح مکان شرطی شده ناشی از مورفین در موش‌های کوچک آزمایشگاهی نر نژاد N-MARI در محدوده وزنی 25-20 گرم بررسی شد. روش بررسی: در یک آزمایش ابتدایی، مقادیر متفاوت مورفین و یا عصاره گیاه به حیوانات تزریق شد تا مشخص شود که آیا مورفین و یا عصاره گیاه توانایی القاء ترجیح مکان شرطی شده را در این حیوان دارند یا خیر. در بخش ...

[ 6 ] - بررسی اثر عصاره آبی کلاله گل زعفران (Crocus sativus L.) بر کسب و بیان حساسیت حرکتی ناشی از مورفین در موش‌های سوری ماده

مقدمه: شیوع اعتیاد به اپیوییدها در کشورما نسبتاً بالا است. این مشکل به دلیل ناشناخته بودن مکانیسم‌های بیولوژیک اعتیاد تاکنون حل نشده است. هدف: در این تحقیق اثر عصاره آبی کلاله گل زعفران (Crocus sativus L.) بر کسب و بیان حساسیت حرکتی ناشی از مورفین در موش‌های کوچک آزمایشگاهی ماده نژاد N-MARI در محدوده وزنی 25-20 گرم بررسی شد. روش بررسی: حیوانات ابتدا با استفاده از مورفین (mg/kg 5، یک‌بار در رو...

[ 7 ] - اثرات تزریق داخل آمیگدالی ممانتین بر علایم متابولیکی استرس مزمن در موش‌های کوچک آزمایشگاهی نر نژاد NMRI

سابقه و هدف: تحقیقات قبلی نقش مهم آمیگدال را در هنگام استرس نشان داده است. هم‌چنین، ورودی‌های گلوتاماتی به آمیگدال در حین استرس فعال می‌شوند. در این مطالعه تاثیر مهار گیرنده‌های گلوتاماتی NMDA موجود در آمیگدال در پاسخ به استرس مزمن مورد بررسی قرار گرفت. مواد و روش‌ها: به کمک دستگاه استریوتاکس کانول‌گذاری یک‌طرفه و یا دو طرفه آمیگدال انجام شد. پس از هفت روز بهبودی حیوانات دوزهای متفاوت مما...

[ 8 ] - اثر استرس آلودگی صوتی در دوران بارداری بر تکوین تشریحی و عمل‌کردی قشر مخ نوازدان در موش‌های کوچک آزمایشگاهی

سابقه و هدف: اثر استرس بر تغییر فعالیت سیستم عصبی کاملاً آشکار است که ممکن است به دلیل تغییر ایجاد شده در ساختمان قشر مخ باشد. در این تحقیق، اثر استرس صدا در مادران باردار بر تغییر ساختمان و عمل‌کرد قشر مخ فرزندان نسل اول موش‌های کوچک آزمایش‌گاهی نژاد NMRI مورد بررسی قرار گرفته است. مواد و روش ‌ ها: موش‌های ماده باردار از روز صفر بارداری به دو گروه تقسیم شدند. گروه کنترل بدون هیچ مداخله‌ای د...

[ 9 ] - تاثیر مصرف خوراکی مورفین در دوران بارداری بر تکامل شبکیه چشم جنین موش‌های بزرگ آزمایشگاهی

سابقه و هدف: سیستم بینایی متشکل از قسمت‌های بسیار متنوع با منشا جنینی متفاوت است. در این تحقیق، اثر مورفین خوراکی بر روی تکامل شبکیه جنین موش‌های بزرگ آزمایشگاهی نژاد ویستار مورد بررسی قرار گرفته است. مواد و روش ‌ ها: تعداد 40 سر موش‌ ماده بزرگ آزمایشگاهی نژاد ویستار با میانگین وزنی 250-300 گرم مورد استفاده قرار گرفتند. پس از حصول اطمینان از بارداری (تعیین روز صفر جنینی، E0 )، موش‌های ماده ...

[ 10 ] - تجویز مورفین خوراکی سبب تأخیر در تکوین قشر بویایی در موش بزرگ آزمایشگاهی نژاد ویستار در دوران جنینی می‌گردد: یک مطالعه مورفومتریک

Background and Objectives: Previous studies have shown that morphine consumption during pregnancy may delay embryo development or cause abnormal nervous system function. This study focused on the effects of maternal morphine consumption on olfactory cortex development in Wistar rats. Material and Methods: In this experimental study, 12 wistar rats (250-300g) were used. The experimental grou...

[ 11 ] - بررسی اثر عصاره زعفران(Crocus sativus) بر کسب و بیان ترجیح مکان شرطی شده ناشی از مورفین در موش‌های کوچک آزمایشگاهی

The Effects of Crocus sativus Extract on the Acquisition and Expression of Morphine-Induced Conditioned Place Preference in Mice M. Mobasher GP , H. Sahraei PhD , B. Sadeghi-Rad , M. Kamalinejad MSc , J. Shams MSc Received: 13/08/05 Sending for Revision: 16/01/06 Receiving Revised Manuscript: 25/09/06 Accepted: 03/10/06 Background and Objective : The effects of Crocus sativus (...

[ 12 ] - اثر اکسید‌نیتریک در بیان حساسیت حرکتی به نیکوتین و آپومورفین در موش

[ 13 ] - تأثیر مصرف خوراکی مورفین بر تکوین لوله عصبی در جنین موش‌های صحرایی حامله

Effects of Oral Morphine on the Neural Tube Development in Obstetric Rats Embryo Sh. Nasiraei-Moghadam MSc1, M. Sadooghi PhD2, H. Bahadoran PhD3, A. Khoshbaten PhD4, H. Mahdavi nasab MSc5, GR. Kaka MSc 5, H. Sahraei PhD6* 1- Academic Member, Dept. of Biology, Azad University, North Branch of Tehran, Iran. 2- Professor, Dept. of Biology, Azad University, North Branch of Tehran, Iran....

[ 14 ] - Effects of the Extremely Low Frequency Electromagnetic Fields on NMDA-Receptor Gene Expression and Visual Working Memory in Male Rhesus Macaques

Introduction: The present research aimed to examine Visual Working Memory (VWM) test scores, as well as hormonal, genomic, and brain anatomic changes in the male rhesus macaques exposed to Extremely Low Frequency Magnetic Field (ELF-MF). Methods: Four monkeys were exposed to two different ELF-MF frequencies: 1 Hz (control) and 12 Hz (experiment) with 0.7 µT (magnitude) 4 h/d for 30 conse...

[ 15 ] - Transient Inactivation of Shell Part of Nucleus Accumbens Inhibits and Exacerbates Stress-Induced Metabolic Alterations in Wistar Rats

Introduction: The role of different parts of the extended amygdala in metabolic signs of stress is not well understood. In the present study, we decided to evaluate the impact of the shell part of nucleus accumbens (NAc) on metabolic disturbance induced by electro foot shock stress using transient inactivation method in the rat.  Methods: Male Wistar rats (W: 230-250 g) were canuulated un...

[ 16 ] - Comparison of effect of intraperitoneal vs. intra-accumbal injection of memantine on response to acute stress in female NMRI mice

Introduction: In this study, the effect of memantine administration into the nucleus accumbens on the metabolic changes induced by acute stress in female mice was evaluated. Methods: Intra-accumbens unilateral or bilateral canulation was performed. One week after recovery, a group of animals were given memantine (1, 0.5, and 0.1 μg/mouse) five min before stress induction intra-accumbally, an...

[ 17 ] - Effects of systemic and intra-accumbal memantine administration on the impacts of plantar electrical shock in male NMRI mice

Introduction: The brain glutamate system plays a central role in response to stress. This study examines the effect of memantine (a NMDA glutamate receptor antagonist) on stress from plantar electrical shock in male NMRI mice (Pasture Institute, Iran), weighing 25-30 g (n=6/group). Methods: The nucleus accumbens was bilaterally cannulated in a group of animals, and seven days later, differen...

[ 18 ] - Dual effect of topiramate on the expression of tolerance to analgesic effects of morphine in mice

Introduction: Topiramate is an anti-convulsant drug, which produces its effects via glutamate metabotropic receptors inhibition and/or GABA receptor excitation. In the present study, attempts were made to investigate the effects of topiramate on the tolerance to morphine-induced analgesia activity in male NMRI mice (20-30 g). Methods: Hot plate method was chosen for the study. First of all t...

[ 19 ] - Assessment of the antidepressant effect of Rosa Canina L. petal extracts in mice by forced swimming stress model

Introduction: Rosa Damasca essential oil is currently used as anti-depressant in animal models and human. Considering the similarities between Rosa Canina and Rosa Damasca, the effects of water and alcoholic extracts of R. Canina on depression induced by forced swimming test (FST) in mice were investigated. Methods: Male NMRI mice (25-30 g) were used (n=6/group). Intraperitoneal injections o...

[ 20 ] - Alterations in dopamine related behavior of the offspring of pregnant Wistar rats exposed to noise pollution stress

Introduction: Effects of stress on nervous system activity and development are well defined. In the present study, the effects of maternal stress on dopamine-related behavior in the offspring were studied. Methods: Female pregnant Wistar rats (200 g) were randomly exposed to the noise pollution stress (125 db) for 14 days (5 min/day). The time of exposure was random in order to avoid adaptat...

[ 21 ] - Reduction of cell size in amygdaloid complex of the Wistar rat embryos after oral morphine consumption

Introduction: In the present study, the effects of oral morphine consumption in pregnant female rats on the amygdaloid complex development in the embryos were investigated. Methods: Female Wistar rats weighing 250-300 g (n=15) were divided into control (n = 8) and experimental groups (n = 7). The experimental group received morphine (0.05 mg/ml) in their tap water. On the 19th day of pregnan...

[ 22 ] - Morphine delays fovea development in the eyes of Wistar rat embryos possible involvement of corticosterone

Abstract* Introduction: Visual system have been considered as among important sensory system in animals’ life span and their survival is closely related to normal visual system functioning. Since in previous studies it have been revealed that morphine consumption during pregnancy could lead to defect and delay in nervous system development in the embryos, in the present study, changes induc...

[ 23 ] - The acqueous extract of Crocus sativus stigma reduce morphine tolerance

Background: Previous studies have indicated that administration of saffron extract could induced reward and reduces morphine reward as investigated by place preference and behavioral sensitization in male and female mice. In the present study, the effects of water extract of Crocus sativus on the acquisition and expression of tolerance to morphine-induced hyperalgesia in female N-MRI mice (20-...

[ 24 ] - Oral administration of morphine delays neural plate development in rat embryos

Previous studies have shown that morphine administration could inhibit neural tube development in rat embryos and produce behavioral defects in human and animals. In the present study, the effects of maternal morphine consumption on embryonic neural plate development in Wistar rats were investigated. Methods: Twenty-four female Wistar rats (250-300 g) were crossed with males. After pregnancy...

[ 25 ] - Study of the effects of intra-nucleus accumbens shell injections of alcohlic extract of Crocus sativus on the acquisition and expression of morphine-induced conditioned place preference in rats

Background: Previous studies have confirm the effects of water extract of Crocus sativus on the euphoric and behavioral properties of morphine in mice. Objective: In the present study, the effects of intra-accumbal administration of alcohol extract of Crocus sativus stigma on the acquisition and expression of morphine-induced conditioned place preference (CPP) in male Wistar rats (250-300 g...

[ 26 ] - The effects of topiramate on the acquisition and expression of morphine-induced place conditioning and behavioral sensitization in mice

Introduction: Topiramate is a newly anti-convulsant drug, which acts as NMDA glutamate receptor antagonist as well as the GABAB receptor agonist. It is used for physical dependence to opioids as well as cocaine, nicotine, alcohol and ecstasy dependence. In the present study attempts were made to further identification of the effects of topiramate on the acquisition and expression of morphine...

[ 27 ] - Olanzapine antagonizes the acquisition and expression of morphine-induced conditioned place preference in male and female mice

Introduction: Several investigations have indicated that dopamine D receptors could influence morphine 2 eward. The influence of olanzapine (a D dopamine receptor antagonist) on the morphine-induced conditioned 2 lace preference (CPP) in male and female mice was investigated in the present study. Methods: The effects of olanzapine on the acquisition and expression of morphine CPP in...

[ 28 ] - Effect of Nitric Oxide on Basolateral Amygdala on Persistence of Anxiety and Depression in Stressed Male Rats

Introduction: The current study aimed at investigating the role of Nitric Oxide (NO) in the maintenance of anxiety and depression induced by stress in male Wistar rats using intra-Basolateral Amygdala (BLA) injection of NO precursor, L-arginine, Nitric Oxide Synthase (NOS) inhibitor, and L-NAME. Methods: Two 23-gauge stainless steel cannulas were placed in the BLA, stereotaxically. Seven days...

[ 29 ] - Antidepressant Effect of Cinnamon (Cinnamomum zeylanicum L.) Water Extract (CWE) Evaluated by Forced Swimming Test in Mice

Background: Few studies have been done considering the effectiveness of aqueous extract of cinnamon in neurological diseases. In previous studies, reducing the pain of hydro-alcoholic cinnamon extract in the second phase (chronic) of the formalin test and reduction of inflammation in animal models as well as in humans following cinnamon administration have been emphasized. There are also studie...

[ 30 ] - Cinnamaldehyde Antagonizes REM Sleep Reduction Induced by Immobilization Stress in Rats

Background and purpose: Sleep and stress are linked in a bidirectional manner. Immobilization stress is a simple model that could be used easily in animal studies for understanding the neurobiology of stress-sleep relationship. Cinnamaldehyde as a herbal medicine with antioxidant activities could be investigated in modulating sleep-stress interaction. Materials and methods: In the present stud...