Sadegh Babashah
Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
[ 1 ] - Dendrosomal Nanocurcumin Induces Changes in the Expression Levels of Heat Shock Proteins in the AGS Cell Line: Cellular Tolerance or Smart Apoptosis Induction
Objectives:The expression levels of heat shock proteins (HSPs) are elevated in many cancers, and this overexpression is often associated with both a poor survival and a therapeutic outcome. Curcumin is an anti-cancer agent that also induces a heat shock response. HSPs confer resistance to curcumin-induced apoptosis in cancerous cells. The aim of the current study was to analyze variations in th...
[ 2 ] - Dendrosomal nanocurcumin and p53 overexpression synergistically trigger apoptosis in glioblastoma cells
Objective(s): Glioblastoma is the most lethal tumor of the central nervous system. Here, we aimed to evaluate the effects of exogenous delivery of p53 and a nanoformulation of curcumin called dendrosomal curcumin (DNC), alone and in combination, on glioblastoma tumor cells. Materials and Methods: MTT assay was exploited to measure the viability of U87-MG cells against DNC treatment. Cells were ...
[ 3 ] - اثرات مهار بیان ژن Msi2 بر الگوی بیانی مسیر Musashi2-Numb و ژنهای درگیر در تکثیر و آپوپتوز سلولهای لوکمی میلوئیدی مزمن
چکیده سابقه و هدف بیان ژن Numb به عنوان ژن تعیینکننده سرنوشت سلول، سبب کاهش رشد سلولهای لوکمیایی و سطوح بالای ژن Msi2 منجر به مهار بیان ژن Numb در سلولهای لوکمی میلوئیدی مزمن می‌گردد. هدف[a1] از مطالعه، مهار ژن Msi2 توسط استراتژی RNAi و اثرات مهار Msi2 بر بیان محور Musashi2-Numb و ژنهای درگیر در تکثیر و آپوپتوز سلولهای لوکمیایی K562 بود. مواد و روش‌ها در این مطالعه تجربی، الیگونوکلئوتید...
[ 4 ] - Signaling pathways involved in chronic myeloid leukemia pathogenesis: the importance of targeting Musashi2-Numb signaling to eradicate leukemia stem cells
Objective(s): Chronic myeloid leukemia (CML) is a myeloid clonal proliferation disease defining by the presence of the Philadelphia chromosome that shows the movement of BCR-ABL1. In this study, the critical role of the Musashi2-Numb axis in determining cell fate and relationship of the axis to important signaling pathways such as Hedgehog and Notch that are essential ...