Seied Abdolhamid Angaji
[ 1 ] - Single Nucleotide Polymorphisms and Association Studies: A Few Critical Points
Uncovering DNA sequence variations that correlate with phenotypic changes, e.g., diseases, is the aim of sequence variation studies. Common types sequence variations are Single nucleotide polymorphism (SNP, pronounced snip).SNPs are the third-generation molecular marker. SNP represents a DNA sequence variant of a single base pair with the minor allele occurring in more than 1% of a given popula...
[ 2 ] - Acute Effects of the Iranian Snake (Naja Naja Oxiana) Venom on Heart
The myocardial effect of snake venoms is considered as one of the most common pathogenesis in many cases of snake envenomation. This study was under taken to investigate the effects of snake (Naja naja oxiana) venom on cardiac function in experimental animals. The blood samples from all the rabbits were collected before venom injection and then 140 µg/kg venom of snake (Naja naja oxiana) was in...
[ 3 ] - Association of Polymorphism at 3׳-UTR of Urokinase Gene with Risk of Calcium Kidney Stones
Urokinase might play a role in the formation of kidney stones. This study was done to determine the association between +4065 T/C polymorphism at the 3′-untranslated region of urokinase gene and calcium kidney stones. This Case-Control study was carried out on 70 cases with a history of calcium kidney stones and 70 controls from the Baqiyatallah hospital of Tehran in 2013. The study of polymorp...
[ 4 ] - بررسی بیان نسبی ژن BIF-1 در تومور سرطان پستان و بافت های نرمال مجاور با استفاده از Real Time PCR
مقدمه: سرطان پستان یک بیماری پیچیده به دلیل چندین تغییر ژنتیکی و اپی‌ژنتیکی است که نهایتا به تغییر فرآیند های سلولی از جمله تکثیر، آپوپتوز، آنژیوژنز (رگ زایی) و اکتساب یک فنوتیپ تهاجمی منجر می‌شود. BIF-1(BAX interacting factor) که یک ژن سرکوب گر تومور است، در تنظیم خمیدگی های غشای میتوکندری نقش دارد و حاوی دمین BAR است که به واسطه آن با BAX تعامل می یابد. هدف از مطالعه حاضر بررسی تفاوت بیا...
[ 5 ] - بررسی ارتباط پلیمورفیسم ناحیه ’UTR٣ ژن اوروکیناز با احتمال ایجاد سنگ‌های کلسیمی کلیه
زمینه: سنگ کلیه یک بیماری چند عاملی شایع در ایران است. عوامل محیطی و ژنتیکی از جمله چند شکلی‌های (پلیمورفیسم) تک نوکلئوتیدی در بروز سنگ کلیه تأثیر‌گذارند. هدف: مطالعه به منظور تعیین ارتباط چندشکلی T/C در نوکلئوتید ٤٠٦٥+ ناحیه غیرترجمه‌شونده ’UTR٣ (′untranslated region٣) ژن اوروکیناز (rs) 4065 با احتمال ایجاد سنگ‌های کلسیمی کلیه انجام شد. مواد و روش‌ها: این مطالعه مورد- شاهدی در سال...
[ 6 ] - Association between rs2735839 and Serum Prostate-specific Antigen Level Regarding Risk of Prostate Cancer in Iranian Population
Background and Objective: Prostate cancer is among the five common cancers in males. It is second cancer in terms of the age-standardized rate (ASR) (ASR=16.6) in Iran. The rs2735839 G/A, an intergenic polymorphism is located on chromosome 19q13.33 at 600 base pairs of the KLK3 gene untranslatable region. This gene which codes prostate-specific antigen (PSA) is used in the screening and diagnos...
[ 7 ] - Association Of rs16260 Polymorphism Of CDH1 Gene With Recurrent Pregnancy Loss In Iranian-Azeri Women
Background & aim: Recurrent pregnancy loss is defined as loosing at least 2 pregnancies before 20th weeks of gestation. Besides all the known causative factors, in about half of the cases, the causing factor, remains unknown. In recent years, some studies have shown the role of candidate genes polymorphisms in RPL. CDH1 is one of these candidate genes that plays critical role in embryo implanta...