Malek Taher Maghsoodlou
Department of Chemistry, Faculty of Science, University of Sistan and Baluchistan, Zahedan, I. R. Iran
[ 1 ] - Mineral elements and essential oil contents of Scutellaria luteo-caerulea Bornm. & Snit.
Objective: Scutellaria luteo-caerulea Bornm. & Snit. is one of the species of genus Scutellaria, within the family of the Lamiaceae, that is used for immune system stimulation and antibacterial effects in traditional medicine in Iran. The aims of this study were to analyze essential oils and mineral element contents of leaves of S. luteo-caerulea in flowering stage of development. Materials an...
[ 2 ] - An efficient and convenient synthesis of quinazoline derivatives catalyzed by cyanuric chloride in water
In this work, an eco-friendly procedure for the preparation of 2,3-dihydroquinazoline-4(1H)-ones was developed by condensation reaction of benzylic and heterocyclic aldehydes with 2-aminobenzamide in the presence of catalytic amounts of cyanuric chloride (2,4,6-trichloro-1,3,5-triazin) as an available and inexpensive organo-catalyst under aqueous media as a green conditions. The new co...
[ 3 ] - Oxalic acid dihydrate catalyzed synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives under thermal and solvent-free conditions
Oxalic acid dihydrate as a green, mild and efficient catalyst for the one-pot three-component Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives from the reaction between β-keto esters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehye derivatives) and urea or thiourea under thermal and solvent-free conditions with excellent yields and short reaction time is st...
[ 4 ] - Chloroacetic acid-promoted heterocyclic reactions: Efficient preparation of tetrahydropyridines and 2,3-dihydroquinazolin-4(1H)-ones
Facile and versatile procedures have been explored for the synthesis of tetrahydropyridines and 2,3-dihydroquinazolin-4(1H)-ones. These protocols employ the one-pot multi-component condensation of arylaldehydes and aromatic amines with β-keto esters and isatoic anhydride in chloroacetic acid, respectively. The reactions proceeded smoothly to generate the corresponding products in high yield. We...
[ 5 ] - A green protocol for synthesis of pyran annulated hetrocyclic systems using Na2SO4 as an efficient catalyst
Na2SO4 as an inexpensive and effective catalyst has provided a green protocol for the synthesis of tetrahydrobenzo[b]pyran, pyrano[2,3-d]pyrimidinone and dihydropyrano[3,2c]chromene derivatives from the three-component domino reaction of aromatic aldehydes and malononitrile with 4-hydroxycoumarin/ dimedone/ barbituric acid in ethanol/water as a mixture of solvent that, this mixture entirely is ...
[ 6 ] - Multicomponent preparation of highly functionalized piperidines using FeCl3.6H2O as an efficient catalyst
FeCl3.6H2O was used as an efficient catalyst for the synthesis of highly functionalized piperidines via a one-pot five-component reaction of aromatic amines, aromatic aldehydes and β-keto esters in EtOH at room temperature. The remarkable advantages offered by this method are good yields, simple procedure, short reaction times, no need to column chromatography and easy work-up. The structures o...
[ 7 ] - Sucrose catalyzes synthesis of 2-amino-4H-chromene: Insight to the kinetics
Sucrose is applied as an efficient catalyst for the three-component reaction consisting of aromatic aldehydes, malononitrile and resorcinol in a mixture of water and ethanol media as green solvents. The advantages of this method are excellent yeild, inexpensive catalyst and more environmentally friendly. Mechanistic insight into the synthesis of 2-amino-4H-chromene included spectral kinetics ap...
[ 8 ] - Kinetics investigation of the synthesis reaction of 2,3-dihydroquinazolin-4(1H)-ones in the presence of acetic acid as a catalyst
Acetic acid has been applied as an efficient catalyst and a green solvent for the two–component condensation reaction consisting of benzaldehyde, 2-amino-benzamide. The advantages of this protocol was excellent yield, short reaction time, mild reaction conditions, higher availability, low costs, more environmentally friendly, lack of need for column chromatography and simple work-up procedure. ...
[ 9 ] - Fe2O3 as an Environmentally Benign Natural Catalyst for One-Pot and Solvent-Free Synthesis of Spiro-4H-Pyran Derivatives
In this work, a simple and economical procedure for the synthesis of spiro-4H-pyranderivatives has been found through the three-component, one-pot condensation of isatin/acenaphthequinone, malononitrile and different reagents including 1, 3-dicrbonyl compounds, naphthol and 4-hydroxycumarin under thermal and solvent-free conditions in the presence ofFe2O<su...
[ 10 ] - Synthesis of Pyrrole Phosphonate Esters: Emphasis on Pyrrole NH Acids and Dialkylacetylenic Esters Substitution
Reaction of dialkyl acetylenedicarboxylates 1a-c andpyrrole derivatives 2a-e in the presence of triphenylphosphite (TPP) was investigated and the effect of the pyrrole substitution was established. Diastereoselectivity is observed with pyrroles, 2a,b, yieldingphosphonate ester derivatives 3a-f and 4,and their relative configuration is determined by 1H/13C and 31</...
[ 11 ] - Sodium Bismuthate: An Efficient Catalyst for the One-pot Synthesis of Biologically Active Spiro[4H-pyran] Derivativesunder Solvent-free Conditions
An efficient sodium bismuthate (NaBiO3) synthesis of biologically active spiro[4H-pyran]derivatives has been accomplished via one-pot three-condensation of isatin/acenaphthequinone, malononitrile and different reagents including 1,3-dicrbonyl compounds, α-naphthol and 4-hydroxycumarin under solvent-free conditions. The notable advantages of the present procedure are: eco-friendly, environmental...
[ 12 ] - One-pot Synthesis of Polysubstituted Dihydro-2oxypyrroles Catalyzed by Vanadium (V) oxide
A mild and efficient synthesis of polysubstituted dihydro-2-oxypyrroles has been developed for the one-pot, four-component domino condensation of dialkyl acetylenedicarboxylate, formaldehyde and aromatic amines using Vanadium (V) oxide as the catalyst at ambient temperature. The use of Vanadium (V) oxide makes this process simple, more convenient, and environmentally friendly.
[ 13 ] - Essential Oil Composition of Elaeagnus angustifolia and Elaeagnus orientalis from Sistan and Baluchestan, Iran
Background & Aim: Elaeagnus angustifolia and Elaeagnus orientalis have a lot of medical utilization. In folk medicine, the fruit and flower of these plants are used as a tonic and antipyretic agent. The aim of the present study was to chemical analysis of volatile constituents of E. angustifolia and E. orientalis flowers. Experimental: The...
[ 14 ] - Convenient One-pot Access to Pyrano[2,3-d]pyrimidine Derivatives via a CuCl2.2H2O Catalyzed Knoevenagel-Michael Addition Reaction in Water/Ethanol Media
Convenient procedure for the synthesis of corresponding pyrano[2,3-d]pyrimidine derivatives were developed via one-pot three-component reaction of aryl aldehyde derivatives, malononitrile with barbituric acids in the presence of copper (II) chloride dihydrate (CuCl2.2H2O) as highly efficient Lewis acid catalyst. This protocol has advantages such as readily and inexpensive catalyst, high reactio...
[ 15 ] - SbCl3 as an Efficient Catalyst for the One-pot Synthesis of Highly Substituted Piperidines
Highly substituted piperidines were synthesized via the condensation of aromatic aldehydes and aromatic amines with β-ketoesters in the presence of antimony(III) chloride at ambient condition. This reaction has any advantages such as easy work-up, clean procedure, and good yields.
[ 16 ] - An Efficient Synthesis of 3,4-Dihydropyrimidin-2-(1H)-one Derivatives Promoted by Antimony Trichloride under Thermal and Solvent-free Conditions
An efficient and simple one-pot approach for the synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives using antimony trichloride (SbCl3) as a mild catalyst by means of three-component Biginelli reaction between β-keto esters, aldehyde derivatives and urea/thiourea under thermal and solvent-free conditions with excellent yields and short reaction times is reported. This m...
[ 17 ] - Synthesis of 6-Amino-4-aryl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles in the Presence of Reusable Catalyst "Celloluse"
Cellulose was applied as a reusable and green catalyst for the facile four-component synthesis of 6-amino-4-aryl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile derivatives using hydrazine monohydrate, ethyl acetoacetate, malononitrile and aryl aldehydes, under solvent-free and thermal conditions. The use of non-toxic and inexpensive catalyst, short reaction time, clean w...
[ 18 ] - A Facile and Efficient Synthesis of Tetrahydrobenzo[b]pyrans Using Sucrose as Green, Inexpensive, Natural and Biodegradable Catalyst
A very efficient one-pot three-component synthesis of pyran derivatives has been improved by condensation of aldehydes and malononitrile with dimedone under 80 °C using sucrose as natural and biodegradable catalyst in water. This method offers some advantages including inexpensive, high to quantitative yields, short reaction time, and easy work-up. Therefore, this methodology is entirely g...
[ 19 ] - بررسی ترکیبات مؤثره و عملکرد آنتیاکسیدانی گیاه Alyssum maritimum و Achillea wilhelmsii در استان سیستان و بلوچستان
در این مطالعه اندامهای هوایی گیاه گل عسلی (Alyssum maritimum) و بومادران ایرانی (Achillea wilhelmsii) بهترتیب از گلخانه دانشگاه سیستان و بلوچستان و منطقه تفتان جمعآوری و به روش تقطیر با آب (دستگاه کلونجر) اسانسگیری گردید. شناسایی ترکیبات با استفاده از دستگاه GC/MS و خواص آنتیاکسیدانی اسانس اندامها به روش تخریب رادیکالهای آزاد (DPPH) سنجیده شد. در اسانس گل عسلی تعداد 3...
[ 20 ] - Y(NO3)3.6H2O catalyzed Four-Component Reaction for the Synthesis of Highly Functionalized Pyrano[2,3-c]pyrazoles in Aqueous Medium
An efficient one-pot four-component protocol for the synthesis of pyrano[2,3-c]pyrazolederivatives has been demonstrated using Y(NO3)3.6H2O as catalyst under mild condition. This isa general synthetic protocol which could be applicable to a wide range of carbonyl compoundsincluding aromatic aldehydes, isatins and acenaphthenequinone. All The reactions proceededsmoothly, ...
[ 21 ] - بررسی ترکیبات مؤثره و عملکرد آنتیاکسیدانی گیاه Alyssum maritimum و Achillea wilhelmsii در استان سیستان و بلوچستان
در این مطالعه اندامهای هوایی گیاه گل عسلی (Alyssum maritimum) و بومادران ایرانی (Achillea wilhelmsii) بهترتیب از گلخانه دانشگاه سیستان و بلوچستان و منطقه تفتان جمعآوری و به روش تقطیر با آب (دستگاه کلونجر) اسانسگیری گردید. شناسایی ترکیبات با استفاده از دستگاه GC/MS و خواص آنتیاکسیدانی اسانس اندامها به روش تخریب رادیکالهای آزاد (DPPH) سنجیده شد. در اسانس گل عسلی تعداد 3...
[ 22 ] - An efficient and convenient synthesis of quinazoline derivatives catalyzed by cyanuric chloride in water
In this work, an eco-friendly procedure for the preparation of 2,3-dihydroquinazoline-4(1H)-ones was developed by condensation reaction of benzylic and heterocyclic aldehydes with 2-aminobenzamide in the presence of catalytic amounts of cyanuric chloride (2,4,6-trichloro-1,3,5-triazin) as an available and inexpensive organo-catalyst under aqueous media as a green conditions. The new co...
[ 23 ] - Oxalic acid dihydrate catalyzed synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives under thermal and solvent-free conditions
Oxalic acid dihydrate as a green, mild and efficient catalyst for the one-pot three-component Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives from the reaction between β-keto esters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehye derivatives) and urea or thiourea under thermal and solvent-free conditions with excellent yields and short reaction time is st...
[ 24 ] - Chloroacetic acid-promoted heterocyclic reactions: Efficient preparation of tetrahydropyridines and 2,3-dihydroquinazolin-4(1H)-ones
Facile and versatile procedures have been explored for the synthesis of tetrahydropyridines and 2,3-dihydroquinazolin-4(1H)-ones. These protocols employ the one-pot multi-component condensation of arylaldehydes and aromatic amines with β-keto esters and isatoic anhydride in chloroacetic acid, respectively. The reactions proceeded smoothly to generate the corresponding products in high yield. We...
[ 25 ] - A green protocol for synthesis of pyran annulated hetrocyclic systems using Na2SO4 as an efficient catalyst
Na2SO4 as an inexpensive and effective catalyst has provided a green protocol for the synthesis of tetrahydrobenzo[b]pyran, pyrano[2,3-d]pyrimidinone and dihydropyrano[3,2c]chromene derivatives from the three-component domino reaction of aromatic aldehydes and malononitrile with 4-hydroxycoumarin/ dimedone/ barbituric acid in ethanol/water as a mixture of solvent that, this mixture entirely is ...
[ 26 ] - Multicomponent preparation of highly functionalized piperidines using FeCl3.6H2O as an efficient catalyst
FeCl3.6H2O was used as an efficient catalyst for the synthesis of highly functionalized piperidines via a one-pot five-component reaction of aromatic amines, aromatic aldehydes and β-keto esters in EtOH at room temperature. The remarkable advantages offered by this method are good yields, simple procedure, short reaction times, no need to column chromatography and easy work-up. The structures o...
[ 27 ] - Sucrose catalyzes synthesis of 2-amino-4H-chromene: Insight to the kinetics
Sucrose is applied as an efficient catalyst for the three-component reaction consisting of aromatic aldehydes, malononitrile and resorcinol in a mixture of water and ethanol media as green solvents. The advantages of this method are excellent yeild, inexpensive catalyst and more environmentally friendly. Mechanistic insight into the synthesis of 2-amino-4H-chromene included spectral kinetics ap...
[ 28 ] - Kinetics investigation of the synthesis reaction of 2,3-dihydroquinazolin-4(1H)-ones in the presence of acetic acid as a catalyst
Acetic acid has been applied as an efficient catalyst and a green solvent for the two–component condensation reaction consisting of benzaldehyde, 2-amino-benzamide. The advantages of this protocol was excellent yield, short reaction time, mild reaction conditions, higher availability, low costs, more environmentally friendly, lack of need for column chromatography and simple work-up procedure. ...
[ 29 ] - Essential Oil Composition of Elaeagnus angustifolia and Elaeagnus orientalis from Sistan and Baluchestan, Iran
Background & Aim: Elaeagnus angustifolia and Elaeagnus orientalis have a lot of medical utilization. In folk medicine, the fruit and flower of these plants are used as a tonic and antipyretic agent. The aim of the present study was to chemical analysis of volatile constituents of E. angustifolia and E. orientalis flowers. Experimental: The...
Co-Authors