Gholamreza Dehghan
Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran, I. R. Iran
[ 1 ] - Effect of five year storage on total phenolic content and antioxidant capacity of almond (Amygdalus communisL.) hull and shell from different genotypes
Objectives: Almond (Prunus amygdalus) hull and shell are agricultural by-products that are a source of phenolic compounds.The processing of almond produce shell and hull, accounts for more than 50% by dry weight of the almond fruits. Recently, more studies have focused on the influence of storage conditions and postharvest handling on the nutritional quality of fruits, especially the antioxidan...
[ 2 ] - Synthesis and Biological Investigation of some Novel Sulfonamide and Amide Derivatives Containing Coumarin Moieties
New sulfonamide and amide derivatives containing coumarin moieties; oxo-2H-chromen-sulfamoylphenylacetamides and oxo-2H-chromen-arylacetamides were synthesized starting from diverse 2-chloroacetamide derivatives and a wide range of coumarins. The structures of the obtained compounds were elucidated by IR and NMR spectra and also analytical elemental analysis. In the next step, the above mention...
[ 3 ] - Effect of endurance training and cinnamon supplementation on post-exercise oxidative responses in rats
Despite the preventative and therapeutic effects of regular exercise, exhaustive exercise may be harmful to health. The present study aimed to determine the protective effect of endurance training and cinnamon bark extract (CBE) supplementation on oxidative responses induced by an exhaustive exercise schedule in rats. The rats were randomly divided into the following five groups of 6; control s...
[ 4 ] - Spectroscopic investigation on the interaction of DNA with superparamagnetic iron oxide nanoparticles doped with chromene via dopamine as cross linker
Objective(s): The interaction of DNA with iron oxide nanoparticles (SPIONs) was studied to find out the interaction mechanism and design new drug delivery systems. Materials and Methods: The interaction of calf thymus DNA (ctDNA) with SPIONs doped with 2H-chromene via dopamine as cross linker (SPIONs@DA-Chr) was studied using the UV absorption spectroscopy, viscosity measurement, circular dichr...
[ 5 ] - Synthesis and Biological Investigation of some Novel Sulfonamide and Amide Derivatives Containing Coumarin Moieties
New sulfonamide and amide derivatives containing coumarin moieties; oxo-2H-chromen-sulfamoylphenylacetamides and oxo-2H-chromen-arylacetamides were synthesized starting from diverse 2-chloroacetamide derivatives and a wide range of coumarins. The structures of the obtained compounds were elucidated by IR and NMR spectra and also analytical elemental analysis. In the next step, the above mention...
[ 6 ] - Protective Effect of Short-term Administration of Ethanolic Saffron Extract on improvement of Cognitive Deficits and Decrement of Lipid Peroxidation induced by Ethidium Bromide in Experimental Models of MS
Introduction: Cognitive dysfunction is recognized as a significant feature of multiple sclerosis (MS). Oxidative stress plays an important role in the pathogenesis of MS. Toxic demyelination by ethidium bromide (EB) is one of the common methods for induction of MS, which leads to neuronal death by production of free radicals and enhancement of oxidative stress burden. According to previous p...
[ 7 ] - بررسی فیتوشیمیایی و اثرات ضد باکتریایی، ضد قارچی و هم افزایی فراکسیون های کلروفرمی عصاره ریشه گیاه کمای بیابانی
زمینه و هدف: گیاه کمای بیابانی (Ferula szowitsiana) متعلق به خانواده چتریان و از گیاهان دارویی بومی ایران و آسیای مرکزی می‌باشد. صمغ حاصل از ریشه گیاهان جنس کما در درمان بیماری های گوارشی و روماتیسم کاربرد دارد. این مطالعه با هدف بررسی اثرات فراکسیون های عصاره کلرفرمی ریشه گیاه کمای بیابانی طراحی و اجرا شده است. روش بررسی: در این مطالعه تجربی اثرات ضد باکتریایی، ضد قارچی و هم افزایی عصاره‌ی کل...
[ 8 ] - مطالعه پارامترهای فیزیولوژیکی و بیو شیمیایی پاسخ به تنش اکسایشی در جلبک پر سلولی شارا به دنبال حذف ماده رنگزای مالاکیت سبز
رشد جمعیت جهانی و افزایش نیاز به صنایع مختلف منجر به تجمع انواع مختلف آلاینده ها در محیط زیست و منابع طبیعی شده است. در این میان صنایع رنگ نساجی در طول فرآیندهای رنگرزی میزان قابل توجهی فاضلاب رنگی را به محیط زیست تخلیه می کند که پساب آن حاوی بسیاری از آلاینده های بازدارنده و اکوتوکسیک می باشد. در این کار پژوهشی، پارامترهای فیزیولوژیکی و بیوشیمیایی (میزان رنگیزه‌های فتوسنتزی و ترکیبات فنولی، فع...
[ 9 ] - بررسی صفات کیفی زردآلو رقم شاهرودی (Prunus armeniaca cv Shahroudi) در طی مراحل مختلف برداشت
امروزه توجه زیادی به کیفیت میوه‌ها از جمله میوه‌های هسته‌دار با توجه به عمر پس از برداشت کوتاه آنها می‌شود. هدف از این پژوهش ارزیابی بعضی از صفات کیفی در طی مراحل پایانی رشد و تعیین زمان مناسبت برداشت زردآلو رقم شاهرودی با توجه به زمان و بازار مصرف بود. میوه‌های زردآلو در فاصله 3 زمان مختلف، (فاصله هر برداشت از برداشت دیگر سه روز بود) برداشت شدند. آزمایش بر طرح بلوک‌های کامل تصادفی در 3 تیمار (...
[ 10 ] - STUDY OF HMGA2 GENE INHIBITION WITH SPECIFIC SHRNA AND SIRNA AND INVESTIGATION OF CORRESPONDING EFFECTS ON DOWNSTREAM GENE EXPRESSION IN MDA-MB-231 CANCER CELLS: A BIOINFORMATIC AND EXPERIMENTAL STUDY
Background & Aims: The use of siRNA to silence gene expression is increasingly expanding today. The aim of this study is to bioinformatically and experimentally investigate the inhibition of the HMGA2 gene and its corresponding effects on downstream genes expression rate in MDA-MB-231 cancer cell treated by shRNA and siRNA specific to HMGA2. Materials & Methods: To perform this bioinformatic a...
[ 11 ] - EVALUATION OF ANTI-CANCER ACTIVITY OF COVALENTLY CONJUGATED METHOTREXATE TO POLYAMIDOAMINE GENERATION 4 DENDRIMER ON MCF-7 CANCER CELLS: AN EXPERIMENTAL STUDY
Background & Aims: Poly (amidoamine) dendrimer (PAMAM) is highly macromolecular at nanosize with widely active amine groups on the surface that allows it to attach to the anti-cancer drugs such as Methotrexate (MTX). This study aimed to synthesize and characterize PAMAM-MTX (dendrimer-MTX) complex, then to evaluate the cytotoxic effect of the synthesized complex on MCF-7 cancer cells. Material...
[ 12 ] - The Protective Effects of Saffron Extract "Crocus sativus'' on Oxidative Stress Reduction in Male Rats with Parkinson’s Disease
Introduction: Parkinson's disease (PD) is among the most common neurodegenerative disorders. Given the powerful antioxidant effects of the saffron extract on the removal of free radicals, this study aimed to investigate the protective effects of the saffron extract on reducing oxidative stress in a rat model of Parkinson's disease pretreated with saffron. Materials & Methods: In this experim...
[ 13 ] - The effect of ethanolic extract of Ferula szowitsiana on cognitive deficits and lipid peroxidation induced by ethidium bromide in experimental model of MS
Introduction: The aim of this study was to investigate the effect of short-term microinjection of Ferula szowitsiana extract on the process of spatial memory and lipid peroxidation in the hippocampus in an experimental model of Multiple Sclerosis (MS). Methods: In this experimental study, 35 male Wistar rats were randomly divided into five groups. Each group has 7 rats. These groups were inclu...
[ 14 ] - EVALUATION OF HMGA2 AND SMARCA5 GENES EXPRESSION IN 4T1 CELLS EXPOSED TO METHOTREXATE: BIOINFORMATIC AND EXPERIMENTAL STUDY
Background & Aims: Breast cancer is a threatening disease in females and is the second common cancer among women after lung cancer. The aim of this research is to bioinformatically and experimentally evaluate the effect of methotrexate (MTX) on the expression of HMGA2 and SMARCA5 genes in the MTX treated 4T1 cancer cell line. Materials & Methods: To perform this study, initially microarray dat...
[ 15 ] - The effects of Quercetin on memory and oxidative stress impairment due to Malathion poisoning in male Wistar rats
Malathion is one of the commonest type of organophosphate insecticide whose toxicity in human body is mainly considered to result from the induction of oxidative stress. The aim of this study was to investigate the antioxidant effect of Quercetin, a flavonoid compound, on the spatial memory and oxidative stress parameters during Malathion poisoning in male Wistar rats. This study was performed ...
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