Jafar Akbari
Traditional and Complementary Medicine Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
[ 1 ] - Effect of Malva sylvestris cream on burn injury and wounds in rats
Objectives: Burn injury is one of the most health-threatening problems in the world. Malva sylvestris (M. sylvestris) flowershave a high mucilage content and are used as a remedy for cut wound and dermal infected wounds in Iranian folklore Medicine. The purpose of this study was to investigate the effect of M. sylvestris cream on the second degree burn injury in rats. Materials and Methods: Fiv...
[ 2 ] - بررسی اثر دما و رطوبت بر سرعت وکینتیک رهش تئوفیلین از ماتریکس های هیدروفیل
Background and purpose: The dissolution of a drug has a major role on its bioavailability. Any change in physico-chemical properties can result in changes in drug release, and furthermore in its bioavailability. Evidence suggest that physicochemical properties of medicinal solids depend on the presence of heat and humidity. In order to overcome such changes, it is necessary to determine the sto...
[ 3 ] - بررسی تاثیر نسبت موسیلاژ Plantago major (بارهنگ) و HPMC K4M بر قدرت مخاط چسبی و سرعت آزادسازی قرص های زیست چسب داخل گونه ای پروپرانولول هیدروکلراید
Background and purpose: Pharmaceutical aspects of mucoadhesion have been the subject of great interest during recent years because it provides the possibility of avoiding either destruction by gastrointestinal contents or hepatic first-pass inactivation of drug. In this study, polysaccharide mucilage derived from the seeds of Plantago major L. (Plantaginaceae family) was investigated for use in...
[ 4 ] - فرمولاسیون و بررسی خصوصیات پراکندگی های جامد پیروکسیکام تهیه شده با پلی اتیلن گلیکول 4000 و توئین 40
Background and purpose: Piroxicam is a non-steroidal anti- inflammatory drug that is characterized by low solubility and high permeability. According to the biopharmaceutic drug classification system, piroxicam is a class 2 drug with low solubility and high permeability. The solid dispersion, ammroach is commonly used to improve the dissolution of poorly water soluble drugs using hydrophilic po...
[ 5 ] - تاثیر گلوسیر 13/50 بر سرعت آزاد شدن ناپروکسن از پراکندگی های جامد تهیه شده با پلی اتیلن گلیکول 4000
Background and purpose: Solubility behavior of a drug is one of the key determinants of its oral bioavailability. The bioavailability may be enhanced by increasing the solubility and dissolution rate of drug by combining the drug with a hydrophilic carrier. Naproxen is a poor water non-soluble analgesic and anti- inflammatory drug. A possible way of overcoming the naproxen low aqueous solubilit...
[ 6 ] - فرمولاسیون و ارزیابی فراورده ژل شونده در محل از فلوکونازول
Background and purpose: In Situ Gel dosage forms are successfully used as drug delivery systems to control drug release and protect the medicaments from a hostile environment. The aim of this study was to formulate and evaluate in situ oral topical gels of fluconazole based on concept of pH triggered system. Materials and methods: An in situ gel system consisting of carbopol 934, hydroxypropyl...
[ 7 ] - بررسی پایداری فیزیکی حالت جامد قرص آتنولول و سازگاری آن با برخی از مواد جانبی قرص‌ها
Background and purpose: Oral route is the most frequently used route for drug administration and tablets are the most popular oral drug forms. The study of drug-excepient compatibility is an important process in development of a stable solid dosage form. Incompatibility between drugs and excipients can alter the stability and bioavailability of drugs, thereby affecting its safety and/or efficac...
[ 8 ] - Evaluation of Buccoadhesive Propranolol Hydrochloride Formulations Containing Plantago psyllium Seed Mucilage and Carbopol 934P
Drug delivery via buccal mucosa by means of buccoadhesive formulations offer distinct advantages over peroral administration. Recently, plant gums and exudates have been screened for their use as pharmaceutical adjuvants. The aim of this study is to evaluate matrix tablets containing Plantago psyllium seed mucilage in addition to carbopol as a mucoadhesive agent, and propranolol hydrochloride a...
[ 9 ] - Efficacy of Camellia sinensis extract against Candida species in patients with denture stomatitis
Background and Purpose: Denture stomatitis is a chronic inflammation disease of the oral mucosa, which is specified by erythematous lesions mainly in the upper palate. Nystatin as a polyene, a class of antifungal agents, is one of the effective drugs to treat denture stomatitis. Considering the expansion of utilizing herbal drugs to cure many kinds of diseases, the present study was conducted t...
[ 10 ] - Efficacy of Sucralfate Ointment in Prevention of Acute Proctitis in Cancer Patients: a Randomized Controlled Clinical Trial
Background: Acute radiation proctitis (ARP) is a usual adverse effect in patients undergoing pelvic radiotherapy. The symptoms include diarrhea, rectal blood or mucus discharge, fecal urgency and tenesmus with pain. Sucralfate, an aluminum-based salt of sucrose octasulfate, is a cytoprotective agent that forms a coating barrier at injured sites by adhering to mucoproteins. It has been used in t...
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