Mohammad Ali Ghaffari
Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
[ 1 ] - Effect of ascorbic acid and alpha-tocopherol supplementations on serum leptin, tumor necrosis factor alpha, and serum amyloid A levels in individuals with type 2 diabetes mellitus
Objective: Diabetes mellitus Type 2 is one of the most widespread chronic metabolic diseases. In most cases, this type of diabetes is associated with alterations in levels of some inflammatory cytokines and hormones. Considering anti-inflammatory properties of plant extracts rich in ascorbic acid (vitamin C) and alpha-tocopherol (vitamin E), anti-diabetic properties of these two well-known anti...
[ 2 ] - مطالعه توزیع بافتی ایندیوم در کبد، کلیه و مغز موش صحرایی
سابقه و هدف: ایندیوم از عناصر اصلی گروه سه جدول تناوبی است که در صنایع مختلف و هم‌چنین علوم پزشکی به‌طور خاص مورد توجه واقع شده‌است. بنابراین احتمال مسمومیت با این فلز، قابل پیش بینی می‌باشد. بر این اساس در این پروژه، مطالعه‌ای بر تجمع ایندیوم در سه بافت کبد، کلیه و مغز انجام شد؛ هم‌چنین آثار پاتولوژیکی این عنصر در بافت‌های مورد نظر نیز بررسی گردید. مواد و روش‌ها: در این مطالعه از موش‌های صحرا...
[ 3 ] - مروری بر متیلاسیون DNA و نقش آن در توموری شدن سلول های تیروئیدی
Epigenetic modification is one of the effective factors in tumorigenesis. Epigenetic processes, especially aberrant DNA methylation, play important role in thyroid cancer, and many tumor suppressor genes including PTEN, RASSF1A and TIMP3 are aberrantly methylated and silenced in thyroid cancer. Because of the specified pattern of DNA methylation in various tumor cells, it is suggested that thes...
[ 4 ] - In vitro Effect of Lead, Silver, Tin, Mercury, Indium and Bismuth on Human Sperm Creatine Kinase Activity: a Presumable Mechanism for Men Infertility
Background: The aim of the present study was to investigate the in vitro effects of mercury (Hg+2), lead (Pb+2), silver (Ag+2), tin (Sn+2), bismuth (Bi+3) and indium (In+3) ions on sperm creatine kinase. Methods: creatine kinase was isolated from human sperm homogenates after chromatography on a DEAE cellulose column. Results: At 60 µg ml-1 metal concentration, 70% of the creatine kinase activi...
[ 5 ] - Glucose Influence on Copper Ion-Dependent Oxidation of Low Density Lipoprotein
Background: It is well established that oxidative modification of low density lipoprotein (LDL) plays a causal role in human atherogenesis and the risk of atherosclerosis is increased in patients with diabetes mellitus. We examined the in vitro effect of glucose on native and glycated LDL oxidation using copper ion dependent oxidation system. Methods: In this study, LDL was isolated from plasma...
[ 6 ] - Influence of Flavonols As in vitro on Low Density Lipoprotein Glycation
The non-enzymatic glycation of Low density lipoprotein (LDL) is a naturally occurring chemical modification of apolipoprotein B as a result of condensation between lysine residues and glucose. Glycated LDL is poorly recognized by LDL receptors and initiates different processes that can be considered proatherogenic. Thus, LDL glycation may contribute in the increased atherosclerotic risk of pati...
[ 7 ] - اثر نارنجین و کوئرسیتین بر اکسیداسیون LDL از طریق تاثیرشان در اتصال مس به LDL در محیط آزمایشگاهی (In Vitro)
Background: The oxidative modification of low density lipoprotein (LDL) may play an important role in atherogenesis. Mechanism of LDL oxidation and factors that determine its susceptibility to oxidation is unknown. Copper is account as an attributing factor in LDL oxidation atherosclerotic lesions. The binding of copper ions to LDL is usually thought to be a prerequisite for LDL oxidation by co...
[ 8 ] - Human Erythrocyte Superoxide Dismutase Encapsulated in Positively Charged Liposomes
Superoxide dismutase (SOD) is an important antioxidant that protects many types of cells from the free radical damage. One of the possible ways for the use of SOD is its incorporation in liposomes. The aim of this study was to investigate the effect of cationic phospholipids on the entrapment of human erythrocyte superoxide dismutase (Cu/Zn SOD) in liposomes. Also, in the present study, w...
[ 9 ] - comparison of serum visfatin levels in restricted diet rats,type2 diabetic rats and insulin resistance rats with normal rats
Background and Purpose: Adipose tissue is not only a site of triglycerides storage, but also an active endocrine organ that secretes many biologically active mediators refered to as "adipokines". Visfatin, as a new adipokine has an important role in Homeostasis of energy and glucose metabolism. In the present study serum visfatin levels in restricted diet rats,type2 diabetic rats and insulin re...
[ 10 ] - Evaluation of Serum Vaspin and Chemerin Levels in Type 2 Diabetic and Treated with Anti Diabetic Drugs Metformin and Acarbose in Rats
Background & Objective: The serum levels of adipose tissue hormons, Vaspin and Chemerin, alter in some disorder conditions such as diabetes. The aim of this study is to investigate the effect of two anti-diabetic drugs (Metformin and Acarbose) and their combination on serum concentration of Vaspin and Chemerin in type 2 diabetic rats. Materials & Methods: 30 male, wistar rats are randomly d...