Siavash Parvardeh
Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
[ 1 ] - Attenuation of morphine tolerance and dependence by thymoquinone in mice
Objectives: Dependence and tolerance are major restricting factors in the clinical use of opioid analgesics. In the present study, the effects of thymoquinone, the major constituent of Nigella sativa seeds, on morphine dependence and tolerance were investigated in mice. Materials and Methods: Male adult NMRI mice were made tolerant and dependent by repeated injections of morphine (50, 50, and 7...
[ 2 ] - Protective effect of α-terpineol against impairment of hippocampal synaptic plasticity and spatial memory following transient cerebral ischemia in rats
Objective(s): Cerebral ischemia is often associated with cognitive impairment. Oxidative stress has a crucial role in the memory deficit following ischemia/reperfusion injury. α-Terpineol is a monoterpenoid with anti-inflammatory and antioxidant effects. This study was carried out to investigate the effect of α-terpineol against memory impairment following cerebral ischemia in rats. Materials a...
[ 3 ] - α-Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide
Objective(s):Dependence and tolerance to opioid analgesics are major problems limiting their clinical application. a-Terpineol is a monoterpenoid alcohol with neuroprotective effects which is found in several medicinal plants such as Myrtus communis, Laurus nobilis, and Stachys byzantina. It has been shown that some of these medicinal plants such as S. byzantina attenuate dependence and toleran...
[ 4 ] - اثرات شل‌کنندگی تیموکینون، ماده مؤثره سیاهدانه (Nigella sativa)، بر عضلات اسکلتی
مقدمه: مطالعات انجام شده روی سیاهدانه (Nigella sativa) نشان می‌دهد که این گیاه دارای اثرات فارماکولوژیک متعددی است که از آن جمله می‌توان به اثرات آرامبخشی، کاهش فعالیت حرکتی و شلی عضلانی اشاره کرد. از آنجا که تیموکینون، مهم‌ترین ماده‌ی مؤثره‌ی موجود در سیاهدانه می‌باشد، این فرضیه مطرح می‌شود که اثرات مهاری سیاهدانه بر سیستم حرکتی - عضلانی، ناشی از تیموکینون باشد. هدف: در این تحقیق، اثر تیموک...
[ 5 ] - The attenuating effect of curcumin on morphine dependence in rats: the involvement of spinal microglial cells and inflammatory cytokines
Background: New evidence suggests an important role for spinal glial cells in development of opioid dependence. Curcumin, a component of the Curcuma Longa, has shown to act as a suppressor of microglial cells. The main goal of this study was to explore the attenuating effects of curcumin on morphine dependence with a focus on spinal microglial cells and inflammatory cytokines. Methods: In...
[ 6 ] - The attenuating effect of curcumin on morphine dependence in rats: the involvement of spinal microglial cells and inflammatory cytokines
Background: New evidence suggests an important role for spinal glial cells in development of opioid dependence. Curcumin, a component of the Curcuma Longa, has shown to act as a suppressor of microglial cells. The main goal of this study was to explore the attenuating effects of curcumin on morphine dependence with a focus on spinal microglial cells and inflammatory cytokines. Methods: In...
[ 7 ] - Minocycline improves memory in a passive avoidance task following cerebral ischemia-reperfusion by enhancing hippocampal synaptic plasticity and restoring antioxidant enzyme activity in rats
Introduction: Oxidative stress plays a crucial role in the impairment of synaptic plasticity following cerebral ischemia which ultimately results in memory dysfunction. Hence, application of antioxidant agents could be beneficial in the management of memory deficit after brain ischemia. Minocycline is a tetracycline antibiotic with antioxidant effect. The main objective of this work was to asse...
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