Somayeh Shafiee

Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

[ 1 ] - The protective effect of Nigella sativa against cisplatin-induced nephrotoxicity in rats

Objective: The clinical use of cisplatin is highly restricted, because of its nephrotoxicity.In this study the protective effect of Nigella sativa (N. sativa) against cisplatin-induced nephrotoxicity was investigated in rats. Materials and Methods: In the current study, the effects of the administration of aqueous-ethanolic extract of N. sativa (100 and 200 mg/kg, BW) and vitamin E (100 mg/kg, ...

[ 2 ] - Effect of Nigella sativa on ischemia-reperfusion induced rat kidney damage

Objective(s):There are a few previously reported studies about the effect of Nigella sativa oil on renal ischemia-reperfusion injury (IRI). The aim of the present study was to test the hypothesis whether pre- or post-treatment with N. sativa hydroalcoholic extract (NSE) would reduce tissue injury and oxidative damages in a clinically relevant rat model of renal IRI.    Materials and Methods: IR...