Reza Hajiaghaee
Department of Pharmacognosy & Pharmaceutics Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
[ 1 ] - In vitro protoscolicidal effects of various concentrations of Ziziphora tenuior L. extract at different exposure times
Objective: Hydatidosis is one of the most important zoonotic diseases and surgery is still the main treatment for this problem. One of the side effects of hydatid cyst surgery is recurrence, thus, searching and assessment of some new agents such as medicinal plant extracts are very important. In the present study, the scolicidal effect of ethanolic extract of Ziziphora tenuior L. (Z. tenuior) w...
[ 2 ] - Optimization of the Glycyrrhizic Acid Extraction from Licorice by Response Surface Methodology
This study aims to extract Glycyrrhizic Acid (GA) from Glycyrrhiza glabra L. (licorice) using a novel, high efficiency, and low-cost extraction method. Water was chosen as the proper solvent for the extraction process to eliminate the requirement of harmful and toxic solvents, prepare an environmentally friendly process, and reduce the costs. The effect of differe...
[ 3 ] - A Randomized Clinical Trial Study: Anti-Oxidant, Anti-hyperglycemic and Anti-Hyperlipidemic Effects of Olibanum Gum in Type 2 Diabetic Patients
Diabetes is a common metabolic disease in the world that has many adverse effects. Olibanum gum resin (from trees of the genus Boswellia) has traditionally been used in the treatment of various diseases such as diabetes. The aim of this study was the comparison of Olibanum gum resin effect with placebo on the treatment of type 2 diabetes. Inclusion criteria was diabetic patients with fasting bl...
[ 4 ] - Two Matrix Metalloproteinase Inhibitors from Scrophularia Striata Boiss
Many species belonging to the Scrophularia genus have been used since ancient times as folk remedies for many medical conditions such as scrofulas, scabies, tumors, eczema, psoriasis, inflammations. The aim of this study was to characterize the matrix metalloproteinases (MMPs) inhibitor compounds of the Scrophularia striata extract by bio-guide fractionation. The aerial parts of S. striata were...
[ 5 ] - Neuroprotective Effect of Total and Sequential Extract of Scrophularia striata Boiss. in Rat Cerebellar Granule Neurons Following Glutamate- Induced Neurotoxicity: An In-vitro Study
Neuroprotective effect of the extract from aerial parts of Scrophularia striata Boiss(Scrophulariaceae) was investigated against glutamate-induced neurotoxicity on cultured rat pupsCerebellar Granule Neurons (CGNs). CGNs from 8 days old Sprague-Dawley rat were preparedand cultured. The experiments were performed after 8 days in culture. The plant was collected fromthe northeastern part (Ruin re...
[ 6 ] - Comparative Chemical Composition and Antioxidant Properties of the Essential Oils and Aromatic Water from Teucrium persicum Boiss
The essential oils and aromatic water, known as Arak in traditional Iranian medicine, comes from the aerial part of Teucrium persicum Boiss., which is grown in Fars Province located in Iran. The samples were collected in summer and the oils and aromatic water were obtained through steam distillation. The chemical composition of the oils was analyzed using GC-MS. An analysis of the chemical...
[ 7 ] - A Randomized Clinical Trial Study: Anti-Oxidant, Anti-hyperglycemic and Anti-Hyperlipidemic Effects of Olibanum Gum in Type 2 Diabetic Patients
Diabetes is a common metabolic disease in the world that has many adverse effects. Olibanum gum resin (from trees of the genus Boswellia) has traditionally been used in the treatment of various diseases such as diabetes. The aim of this study was the comparison of Olibanum gum resin effect with placebo on the treatment of type 2 diabetes. Inclusion criteria was diabetic patients with fasting bl...
[ 8 ] - Two Matrix Metalloproteinase Inhibitors from Scrophularia Striata Boiss
Many species belonging to the Scrophularia genus have been used since ancient times as folk remedies for many medical conditions such as scrofulas, scabies, tumors, eczema, psoriasis, inflammations. The aim of this study was to characterize the matrix metalloproteinases (MMPs) inhibitor compounds of the Scrophularia striata extract by bio-guide fractionation. The aerial parts of S. striata were...
[ 9 ] - Neuroprotective Effect of Total and Sequential Extract of Scrophularia striata Boiss. in Rat Cerebellar Granule Neurons Following Glutamate- Induced Neurotoxicity: An In-vitro Study
Neuroprotective effect of the extract from aerial parts of Scrophularia striata Boiss(Scrophulariaceae) was investigated against glutamate-induced neurotoxicity on cultured rat pupsCerebellar Granule Neurons (CGNs). CGNs from 8 days old Sprague-Dawley rat were preparedand cultured. The experiments were performed after 8 days in culture. The plant was collected fromthe northeastern part (Ruin re...
[ 10 ] - Comparative Chemical Composition and Antioxidant Properties of the Essential Oils and Aromatic Water from Teucrium persicum Boiss
The essential oils and aromatic water, known as Arak in traditional Iranian medicine, comes from the aerial part of Teucrium persicum Boiss., which is grown in Fars Province located in Iran. The samples were collected in summer and the oils and aromatic water were obtained through steam distillation. The chemical composition of the oils was analyzed using GC-MS. An analysis of the chemical...
[ 11 ] - مروری بر گیاهان دارویی جنس شنگ (Tragopogon Spp.)
جنس شنگ از خانواده آستراسه (کاسنی) و طایفه لاکتوسه یا شیکوریا (Cichorieae) است. گستردگی وسیع گیاهان این جنس در مناطق مختلف باعث شده تا علاوه بر کاربردهای دارویی به صورت فراگیری به عنوان سبزی خوراکی یا حتی علوفه دام کاربرد داشته باشند. از قسمت‌های مختلف این گیاهان در درمان دل درد و ناراحتی‌های گوارشی استفاده می‌شود، همچنین در طب سنتی ایران از شنگ به عنوان بند آورنده خونریزی و بهبوددهنده زخم در خ...
[ 12 ] - مروری بر خواص دارویی گیاهان رنگ‌زا
رنگ‌ها، یکی از پرمصرف‌ترین مواد در صنایع مختلف هستند. امروزه توجه زیادی به جایگزینی رنگدانه‌های طبیعی به جای رنگ‌های سنتزی معطوف شده است. یکی از مهم‌ترین منابع جهت تولید رنگدانه‌های طبیعی، گیاهان می‌باشند. گیاهان رنگ‌زا در جهان بسیار متعدد هستند. تعداد اندکی از آنها به صورت صنعتی و بخشی نیز به صورت سنتی مورد استفاده قرار می‌گیرند. در حال حاضر تقاضا برای رنگ‌های طبیعی به دلیل قابلیت برگشت آنها...
[ 13 ] - مروری سیستماتیک بر تأثیر گیاهان دارویی در درد پس از برش سزارین و برش پرینه
مقدمه: اپی‌زیاتومی، برش پرینه به منظور افزایش قطر تنگه خروجی لگن در هنگام زایمان طبیعی است و شایع‌ترین برش جراحی در مامایی می‌باشد و سزارین هم رایج‌ترین عمل جراحی است که میزان آن در ایران و جهان رو به افزایش نهاده است. هدف: مقصود از این بازنگری سیستماتیک، خلاصه کردن تحلیل کارآزمایی‌های بالینی انجام شده در ایران و در جهان و بررسی ایمنی و کارآیی استفاده از گیاهان دارویی برای تسکین درد و تسریع در...
[ 14 ] - سنتز سبز نانو ذرات آهن با استفاده از عصاره Mentha longifolia L.
مقدمه: نانوذرات آهن صفر ظرفیتی به دلیل خصوصیت کاهندگی بالا موجب تخریب بسیاری از آلاینده‌ها می‌شوند. در میان روشهای سنتز نانوذرات آهن، سنتز سبز با استفاده از عصاره‌های گیاهی برای سنتز نانوذرات سودمندتر از دیگر روش‌ها است. هدف: در این پژوهش، نانوذرات آهن صفر در یک فرآیند یک مرحله‌ای بوسیله‌‌ی عصاره گیاهMentha longifolia L. ، که شامل ترکیبات فنولی است، از احیاء نمک کلرید آهن شش آبه، سنتز می‌شوند....
[ 15 ] - بررسی تأثیر حلال مصرفی، خوراک ورودی و روش روغن‌گیری در تهیه عصاره استاندارد شده سیلی‌مارین
مقدمه: گیاه خارمریم (Silybum marianum) گیاهی یکساله یا دو ساله بومی نواحی مدیترانه‌ای است که در سراسر دنیا به صورت کاشته شده یافت می‌شود. عصاره تهیه شده از بذرهای این گیاه برای درمان بیماری‌های کبد از زمان باستان مورد استفاده بوده است. ترکیبات شاخص این گیاه دارویی ترکیبات فلاونولیگنانی هستند که از سیلی‌بین به عنوان مهم‌ترین آنان یاد می‌شود. هدف: هدف از این مطالعه بررسی اثر انواع خوراک ورودی، نو...
[ 16 ] - مروری تحلیلی بر روشهای جداسازی و اندازه‌گیری اسید گلیسیریزیک از گیاه شیرین‌بیان
گیاه شیرین‌بیان (Glycyrrhiza glabra L.)، یک گیاه چند ساله از خانواده بقولات Fabaceae است. این گیاه به واسطه دارا بودن ترکیبات ثانویه مهم در ریزوم خود در دنیا حائز اهمیت بوده و مورد توجه صنایع دارویی، غذایی و حتی دخانیات قرار گرفته است. این گیاه به علت مصارف گسترده جهانی از نظر صادرات دارای اهمیت زیادی می‌باشد. مهم‌ترین ترکیب فعال آن از دسته ساپونین‌ها [تری ترپن 5 حلقه‌ای]، به نام گلیسریزیک اسید...
[ 17 ] - بررسی اثر عصاره اسطوخودوس بر تکثیر لنفوسیتی و سایتوکاین فاکتور نکروزدهنده تومورآلفا
مقدمه: مطالعات زیادی نشان دادند که عصاره گیاهان دارای اثرات متنوع بیولوژیکی از قبیل خواص ایمونومدولاتوری می‌باشند. هدف: در این تحقیق، خواص ایمونومدولاتوری عصاره گیاه اسطوخودوس بر تکثیر لنفوسیتی و سایتوکاین فاکتور نکروز دهنده تومور الفا، بررسی شد. روش بررسی: آزمایش ورود تیمیدین نشاندار بر سلول‌های تک هسته‌ای خون محیطی تحریک شده با میتوژن فیتوهماگلوتینین جهت اثر بر تکثیر لنفوسیتی و تولید سا...
[ 18 ] - بررسی اثر ضدمیکروبی عصاره تام و فراکسیون‌های گیاه Geum kokanicum
مقدمه: گیاه علف مبارک کوهستان با نام علمی Geum kokanicum از خانواده Rosaceae ، از جمله گیاهان با ریزوم دایمی ایران می‌باشد. این گیاه در درمان اسهال و سایر مشکلات گوارشی کاربرد دارد. هدف: در این تحقیق اثرات ضدمیکروبی عصاره تام و فراکسیون‌های مختلف تهیه شده از ریزوم G. kokanicum مورد بررسی قرار گرفت. روش بررسی: گیاه G. kokanicam درخرداد ماه 1385 از منطقه بجنورد جمع‌آوری شد. سپس از ریزوم آن یک ...
[ 19 ] - Allometric Ratio of Menthol and Menthone to Pulegone in the Essential Oil of Peppermint (Mentha piperita L.) Affected by Bioregulators
Background and objectives: Menthol and menthone are two important components in the essential oil of peppermint(Mentha piperita L.) which are commercially used in the pharmaceutical industries. This study has presented the allometric ratio of menthol and menthone to pulegone affected by the induction of bioregulators. Methods: The experiment w...
[ 20 ] - Alteration of Depressive-like Behaviors by Psilocybe cubensis Alkaloid Extract in Mice: the Role of Glutamate Pathway
Background and objectives: Considering the increasing prevalence of depression, many studies are launched to investigate new antidepressant treatments. The present research has shown how psilocybin as an active compound of Psilocybe cubensis (Earle) Singer extract (PCE) can change the parameters related to depression and anxiety in animal models. Both ...
[ 21 ] - Effects of standardized hydro-alcoholic extract of Vaccinium arctostaphylos leaf on hypertension and biochemical parameters in hypertensive hyperlipidemic type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial
Objective: To study the blood pressure, lipid and glycemic effects and safety of Vaccinium arctostaphylos leaf in the hypertensive hyperlipidemic type 2 diabetic patients. Materials and Methods: The patients took 350 mg standardized plant leaf hydro-alcoholic extract capsule (n=50) or placebo capsule (n=50) three times daily alongside conventional drugs for 2 months. At the baseline and endpoin...
[ 22 ] - Immunomodulatory and Anti-Inflammatory Effects of Scrophularia megalantha Ethanol Extract on an Experimental Model of Multiple Sclerosis
Background and objectives: Scrophularia megalantha is a native Iranian plant. In folk remedies, the species of the genus are used to treat stomach ulcers, goiter, eczema, cancer, psoriasis, and gall; however, there is not much research about S. megalantha. The current study aimed at evaluating the therapeutic effect of Scrophularia megalantha, a medic...
[ 23 ] - Hydatid Cyst Killing Mechanism of Ziziphora tenuior by Inducing Apoptosis via Mitochondrial Intrinsic Pathway
Background and objectives: Ziziphora tenuior is considered as an appropriate protoscolicidal agent yet the mechanism of such effect is not known so far. The aim of this study was to evaluate the apoptotic effect of Z. tenuior extract on protoscolices of hydatid cyst. Methods: Protoscolices were collected aseptically and the Bradford test was e...
[ 24 ] - Statistical Optimization of Production Conditions of Polycaprolactone-Chitosan-Curcumin Particles
Curcumin is an herbal plant with great therapeutic applications. Although it is useful in treating several diseases, its low solubility in water and low bioavailability in living systems are limiting factors in using curcumin as a medicine. One way to overcome these shortcomings is the production of curcumin micro/nano particles. In this research, the particles of curcumin loaded with polycapro...
[ 25 ] - Changes in the Essential Oil Content and Composition of Lippia citriodora under Vacuum Oven-drying and Pre-drying Operation
Background: Pre-drying operations and drying methods have a significant effect on the quantity and quality of plants essential oils. Objective: In this study, the effect of pre-drying operation and vacuum oven-drying was investigated on the essential oil content and composition of Lippia citriodora. Method: This research was conducted as a factorial experiment in a completely randomized desig...
[ 26 ] - Effect of ginger supplement on lipid peroxidation induced by exercise- A meta-analysis study
Background: There are often discrepancies in the results of various studies in the field of exercise and herbal supplements. Objective: The aim of this study was to combine the contradictory results of several studies on the effectiveness of ginger supplement on lipid peroxidation in exercise. Methods: This meta-analysis consists of a total of 3 eligible studies selected from among the 6 studie...
Co-Authors