Ali Gorji
Epilepsy Research Center, Department of Neurology, and Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany
[ 1 ] - Curcumin attenuates harmful effects of arsenic on neural stem/progenitor cells
Objective: Arsenic, an environmental pollutant, decreases neuronal migration as well as cellular maturation and inhibits the proliferation of neural progenitor cells. Curcumin has been described as an antioxidant and neuroprotective agent with strong therapeutic potential in some neurological disorders. Human adipose-derived stem cells (hADSCs), a source of multipotent stem cells, can self-rene...
[ 2 ] - Avicenna's Canon of Medicine: a review of analgesics and anti-inflammatory substances
Naturally occurring substances mentioned in medieval medical literatures currently have, and will continue to have, a crucial place in drug discovery. Avicenna was a Persian physician who is known as the most influential medical writers in the Middle ages. Avicenna`s Canon of Medicine, the most famous books in the history of medicine, presents a clear and organized summary of all the medical kn...
[ 3 ] - Garlic: a review of potential therapeutic effects
Throughout history, many different cultures have recognized the potential use of garlic for prevention and treatment of different diseases. Recent studies support the effects of garlic and its extracts in a wide range of applications. These studies raised the possibility of revival of garlic therapeutic values in different diseases. Different compounds in garlic are thought to reduce the risk f...
[ 4 ] - Survival, proliferation, and migration of human meningioma stem-like cells in a nanopeptide scaffold
Objective(s): In order to grow cells in a three-dimensional (3D) microenvironment, self-assembling peptides, such as PuraMatrix, have emerged with potential to mimic the extracellular matrix. The aim of the present study was to investigate the influence of the self-assembling peptide on the morphology, survival, proliferation rate, migration potential, and differentiation of human meningioma st...
[ 5 ] - Proconvulsive effect of hydrochlorothiazide in an in vitro rat seizure model
Objective(s):Protective effects of diuretics, particularly of hydrochlorothiazide (HCT), for the development of seizure attacksepilepsy have been described in vivo. However, itsthe mechanism of action of HCT is unknownneeds to be elucidated. Materials and Methods: Extracellular field potentials were recorded from the CA1- and CA3-subfields of the hippocampus of rats. Epileptiform discharges wer...
[ 6 ] - Effect of Cannabinoid Receptor Activation on Spreading Depression
Objective(s) The objective of this study was to evaluate the effect of cannabinoid on cortical spreading depression (CSD) in rat brain. Cannabis has been used for centuries for both symptomatic and prophylactic treatment of different types of headaches including migraine. CSD is believed to be a putative neuronal mechanism underlying migraine aura and subsequent pain. Materials and Methods T...
[ 7 ] - بررسی تداخلات دارویی در جانبازان با مشکلات روانپزشکی
مقدمه: تداخلات دارویی از مشکلات عمده در درمان بیماری ها است. تجویز همزمان گروه های مختلف دارویی ممکن است منجر به اختلال در تاثیر هر یک از داروها به تنهایی گردد که به این اثرات متقابل دارو ها، تداخل دارویی گفته می شود. خطر تداخل دارویی در بیماران مبتلا به بیماری مزمن که معمولا تعداد داروهای بیشتری مصرف می کنند افزایش می یابد. مواد و روش ها: این مطالعه روی مجروحین جنگی مراجعه کننده به بیمارستان ر...
[ 8 ] - O19: Cellular Injury and Various Receptor Expression in the Epileptic Human Amygdala
لطفاً به چکیده انگلیسی مراجعه شود.
[ 9 ] - O23: Differentiation of Human Neural Stem-Like Cells Derived from Epileptic Amygdala Tissue into Motor Neurons
لطفاً به چکیده انگلیسی مراجعه شود.
[ 10 ] - P9: Isolation and Culture of Adult Microglia Cells Derived from Epileptic Human Brain Tissue
لطفاً به چکیده انگلیسی مراجعه شود.
[ 11 ] - O13: Human Neural Stem/Progenitor Cells Derived from Epileptic Human Brain in A Self-Assembling Peptide Nanoscaffold Attenuates Neuroinlammation in Traumatic Brain Injury in Rats
Traumatic brain injury (TBI) is a disruption in the brain functions following a head trauma. Cell therapy may provide a promising treatment for TBI. Human neural stem cells cultured in self-assembling peptide scaffolds have been proposed as a potential novel method for cell replacement treatment after TBI. In the present study, we accessed the effects of human neural stem/progenitor cells (hNS/...
[ 12 ] - O14: Application of Neural Stem Cells Derived from Human Meningioma in Traumatic Brain Injury
Traumatic brain injury is considered as one of the main causes of morbidity and mortality worldwide. Apart from primary mechanical injury, Secondary injuries due to inflammation and apoptosis result in great neuronal damage. Current treatments are not able to regenerate the damaged part and prevent future sequels. Using human stem cells with self-assembling scaffolds may be promising in treatme...
[ 13 ] - O27: Interaction of Cancer Stem Cells and Microglia in Glioblastoma Multiforme
Malignant gliomas are highly invasive brain tumors with the occurrence of multiple microglia/macrophages in the tumor microenvironment. Macrophages/microglia that found in glioma microenvironment, as tumor-infiltrating immune cells, can play a harmful role in tumor progression. In addition, glioblastoma multiforme (GBM) contains multiple aberrant differentiation and tumorigenic cancer stem cell...
[ 14 ] - P10: Isolation and Culture of Primary Microglial Cells from Glioblastoma Patients
Glioblastoma multiform (GBM) is the most common and malignant form of glial tumors. GBM microenvironment contains various cell types showing characteristics of activated or dimorphic macrophages/microglia. Some of these cells provide significant help for tumor growth, while others are able to inhibit tumor progression. Microglia play a major role in brain function by monitoring tissue for patho...
[ 15 ] - P11: Assess the Electrophysiological Activity of Olfactory Bulb in the Animal Model of PTSD and its Relationship with Neuroinflammation in the Olfactory Bulb
Post-traumatic stress disorder (PTSD) is a mental health condition that's triggered by a terrifying event - either experiencing it or witnessing it. In addition to the relationship between PTSD and neuroinflammation, research indicates that olfactory bulb are effective in anxiety disorders. The aim of this study was to assess the electrophysiological activity of olfactory bulb in the animal mod...
[ 16 ] - O 20: The Role of Neuroinflammation in Epilepsy: A New Target for Treatment
Despite progress in pharmacological and surgical treatments of epilepsy, little is known about the processes that a healthy brain is rendered epileptic after seizure occurrence. Growing evidence supports the involvement of inflammatory processes, both the adaptive immunity and systemic inflammatory response, in induction of individual seizures as well as in the epileptogenesis. Clinical and exp...
[ 17 ] - O 26: Treatment of Traumatic Brain Injury in Adult Rats with Injection of Human Epileptic Neural Stem Cells and Nano-Scaffold
Traumatic brain injury (TBI) is described by a disruption in the normal function of the brain due to an injury following a trauma, which can potentially cause severe physical, cognitive, and emotional impairment. The use of human stem cells and self-assembling peptide scaffolds suggest huge potential for application in the treatment of TBI. In the present study, we surveyed the beneficial effec...
[ 18 ] - O3: Importance of Road Safety on Public Health
لطفاً به چکیده انگلیسی مراجعه شود.
[ 19 ] - P3: Neuronal Death Following Posttraumatic Excitability and Seizure
لطفاً به چکیده انگلیسی مراجعه شود.
[ 20 ] - O1: The Importance of Anxiety and Stress Relief Programs
Stress is a physiological reaction to the ever-increasing demands of life. After each stressful event, the body should be returned to a normal relaxed state. However, continuous stress of modern life sometimes put the subjects at risk of developing a range of diseases; from psychosomatic to anxiety disorders. Stress management program gives a range of tools to reduce the impact of stress and pr...
[ 21 ] - اثر تصادفات جاده‌ای بر آسیب مغزی
مقدمه: آسیب‌های مغزی در نتیجۀ برخورد ناگهانی و شدید سر با جسم سخت رخ می‌دهند که می‌تواند به صورت خفیف، متوسط یا شدید باشد. صرع، سردردهای مداوم، خونریزی مغزی، عفونت، ضربه، زوال عقل، عقب ماندگی ذهنی، مرگ مغزی، اختلالات خلقی و روانی، همچنین اختلالات هورمونی از پیامدهای آسیب‌های مغزی هستند که گاهی اوقات در سراسر زندگی مداوم باقی می‌ماند. علل اصلی آسیب مغزی پس از ضربه، تصادفات، سقوط، درگیری فیزیکی، ...
[ 22 ] - بهبود ایمنی راه کودکان در ایران
مقدمه: تصادفات ترافیکی جاده‌ای منجر به حدود 186300 مرگ و میر کودکان در سال و همچنین میلیون ها آسیب دیدگی از جمله ترومای مغز و ستون فقرات می‌گردد. تصادفات جاده‌ای ممکن است منجر به معلولیت و بیماری‌های مزمن مانند صرع مقاوم به درمان و اختلالات شناختی شود. دو سوم از تلفات و مجروحیت ناشی از سوانح ترافیکی در کشورهای کم درآمد و یا با درآمد متوسط رخ می‌دهد. به منظور نشان دادن اهمیت مسئله سلامت عمومی و...
[ 23 ] - O1: Importance of Child Safety on the Road
Worldwide, more than 185,000 children under 18 years die from road traffic accidents annually (each four minutes a child death occurred due to road crashes); with most casualties from developing countries. 95% of road traffic fatalities among children occur in developing countries. Many more children are injured, often severely, and suffering from different disabilities. Road accidents cause ex...
[ 24 ] - P1: Three Dimensional Cultivation of Neural Stem Cells by Pura Matrix
There are two main methods for preparing the PuraMatrix (PM) as a three-dimensional (3-D) scaffold for supporting the cells including surface plating and encapsulation. In the surface-plating procedure, the scaffold is created by adding an ionic agent such as medium to PM. After adjusting the PH by changing the medium, cells are seeded on top of the scaffold. In the encapsulation method, PM and...
[ 25 ] - O2: Neuroscience and Talent: How Neuroscience Can Enhance Successful Plan of Talent Strategy
Performance and development are based on hard work, experience and learning. Learning how to change different behaviors is crucial to successful talent management plans. Within the brain there are complex connected circuits that can identify threats. The brain reacts to change as a threat. There is also a collection of brain structures tied to a natural reward system that are involved in the re...
[ 26 ] - P18: Signaling Pathway in Long-Term Potentiation
Synaptic plasticity in the central nervous system (CNS) of mammals has been discussed for many years. Several forms of synaptic plasticity of mammal’s CNS have been identified, such as those that occur in long-term potentiation (LTP). Different types of LTP have been observed in distinctive areas of the CNS of mammals. The hippocampus is one of the most important areas in the CNS that pla...
[ 27 ] - شیوع اضافه وزن و چاقی در بیماران آسیب نخاعی
مقدمه: چاقی یکی از شایع‌ترین مشکلات مرتبط با رژیم غذایی می‌باشد و خطر بیماری‌های دیابت شیرین، فشارخون بالا، تصلب شرایین و چربی خون بالا را افزایش می‌دهد. بیماری‌های قلبی -عروقی یکی از علل اصلی ناخوشی و مرگ و میر در افراد مبتلا به آسیب نخاعی هستند. افزایش تودۀ چربی به عنوان یک عامل خطر مهم در بیماران با آسیب نخاعی مزمن مشخص شده است و کنترل وزن به عنوان یک استراتژی مهم در پیشگیری از بیماری‌های قل...
[ 28 ] - P84: Intractable Post-Traumatic Epilepsy: Clinical Analysis of Patients with Blunt and Penetrating Head Injuries Sustained in War
لطفاً به چکیده انگلیسی مراجعه شود.
[ 29 ] - P86: Effect of Concomitant Use of Erythropoietin and Progesterone in Traumatic Brain Injury
لطفاً به چکیده انگلیسی مراجعه شود.
[ 30 ] - P87: Closed Traumatic Brain Injury Model in Sheep Mimicking High-Velocity, Closed Head Trauma in Humans
لطفاً به چکیده انگلیسی مراجعه شود.
[ 31 ] - O1: Anxiety As a Global Problem
Several investigations demonstrated that anxiety is the most common mental health disorder worldwide affected about one in 13 people. Anxiety disorders are more commonly reported in Western societies but it is also a main health problem in non-Western countries as stress and anxiety levels have drastically increased over the last two decades. Several wars in Middle Eastern countries in the last...
[ 32 ] - اثرات محافظتی عصبی استفادۀ همزمان از اریتروپویتین و پروژسترون در صدمۀ مغزی ناشی از ضربه
مقدمه: آسیب‌های ناشی از ضربه‌های مغزی ممکن است موجب اختلالات عصبی مانند تغییر سطح هوشیاری یا کما، عملکرد غیرطبیعی سیستم حسی- حرکتی و حملات تشنجی گردد. اثرات محافظت عصبی پروژسترون و اریتروپویتین در انواع مختلف صدمات مغزی و ایسکمی مغزی نشان داده شده است. هدف از این مطالعه، بررسی احتمال افزایش اثرات محافظت عصبی پروژسترون و اریتروپویتین بعد از صدمات مغزی است. مواد و روش‌ها: اثرات پروژسترون، اریتروپ...
[ 33 ] - جراحی مغز در حالت هوشیاری کامل: درمان سه بیمار مبتلا به صرع مقاوم به درمان ناشی از تومور مغزی در ایران
مقدمه: جراحی مغز در حالت هوشیاری کامل ما را قادر می سازد تا عملکرد سیستم عصبی را در جریان عمل جراحی بررسی نماییم. در بیمارانی که تومور مغزی آن ها در نزدیکی مناطق حساس مغز نظیر مرکز تکلم یا منطقه ی حرکتی کورتکس می باشد، انجام جراحی مغز در حالت هوشیاری که اجازه می دهد بوسیله ی تحریک مستقیم قشر مغز نقشه ی مناطق مختلف را مشخص کند، توصیه می شود. توصیف بیمار: سه بیمار (دو مرد جانباز و یک زن، بین سنین...
[ 34 ] - مروری بر صرع کوچک با رویکرد به علوم پایه
Abstract Background: Epilepsy is one of the most common neurological disorders. Seizures could be presented as general or focal attacks. Absence epilepsy is one of the main forms of the general epilepsy and associated with sudden impairment of consciousness and non/convulsive generalized attacks. The prevalence of absence epilepsy was estimated about 10% of all types of seizures and seizures o...
[ 35 ] - Modulatory Effects of Dopamine D2 Receptors on Spreading Depression in Rat Somatosensory Neocortex
Introduction: Spreading depression (SD) is a propagating wave of depolarization followed by depression of the neuroglial activities and can modulate extracellular dopamine concentrations in the neocortex. It has been shown that the dopaminergic system plays a role in migraine. SD has been suggested as a critical phenomenon in the pathophysiology of migraine. The aim of this study was to investi...
[ 36 ] - Generation of motor neurons from human amygdala-derived neural stem-like cells
Objective(s): Among several cell sources, adult human neural stem/progenitor cells (hNS/PCs) have been considered outstanding cells for performing mechanistic studies in in vitro and in vivo models of neurological disorders as well as for potential utility in cell-based therapeutic approaches. Previous studies addressed the isolation and culture of hNS/PCs from human neocortical and hippocampal...
[ 37 ] - Review on the Third International Neuroinflammation Congress and Student Festival of Neuroscience in Mashhad University of Medical Sciences
Introduction: Neuroinflammation congress was the third in a series of annual events aimed to facilitate the investigative and analytical discussions on a range of neuroinflammatory diseases. The neuroinflammation congress focused on various neuroinflammatory disorders, including multiple sclerosis, brain tumors, epilepsy, and neurodegenerative diseases. The conference was held in June 11-13, 20...
[ 38 ] - Neuronal injury and death following focal mild brain injury: The role of network excitability and seizure
Objective(s): While traumatic brain injury (TBI) is a predisposing factor for development of post-traumatic epilepsy (PTE), the occurrence of seizures following brain trauma can infuriate adverse consequences of brain injury. However, the effect of seizures in epileptogenesis after mild TBI cannot yet be accurately confirmed. This study was designed to investigate the ...
[ 39 ] - Lentiviral vector-mediated transduction of adult neural stem/progenitor cells isolated from the temporal tissues of epileptic patients
Objective(s): Neural stem/progenitor cells (NS/PCs) hold a great potential for delivery of therapeutic agents into the injured regions of the brain. Efficient gene delivery using NS/PCs may correct a genetic defect, produce therapeutic proteins or neurotransmitters, and modulate enzyme activation. Here, we investigated the efficiency of a recombinant lentivirus vector ...
Co-Authors