Hojjatollah Alaie
Department of Physiology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
[ 1 ] - The effect of hydro-alcoholic of Phoenix Dactylifera extract on sleep and EEG in rat
Objective: Hard envelope of date palm pollen is used as a sedative and calmative compounds in Iranian traditional medicine. We tried to study the effects of Phoenix dactylifera (Tarooneh) extract on sleep time and Brian waves. Materials and Methods: Rats were divided into control and test groups in sleep experiment. Control groups included intact group (without any injection), negative control ...
[ 2 ] - The effect of red grape juice and exercise, and their combination on parkinson’s disease in rats
Objective: Parkinson's disease (PD) is one of the most common neurodegenerative disorders which is characterized by tremor, rigidity, bradykinesia and postural disturbances. Studies indicate that grape juice and exercise may have beneficial effects on neurodegenerative disorders. Therefore, in the present study, we evaluated the effects of red grape juice (GJ) together with treadmill running on...
[ 3 ] - MORPHINE RELE ASES GLUTAMATE THROUGH AMPA RECEPTORS IN THE VENTRAL TEGMENTAL AREA: A MICRODIALYSIS STUDY IN CONSCIOUS RATS
In vivo microdialysis was used to study the effects of morphine on glutamate release from the ventral tegmentum area (VTA) in freely moving rats. Intraperitoneal (i.p.) injection of acute and repeated morphine at increasing doses significantly enhanced glutamate release. Only a minor tolerance developed to this dosage of morphine. AP-S (2-amino-5-phosphonovaleric acid, 0.5 mg/kg i.p.), a N...
[ 4 ] - Modulatory effect of ventromedial hypothalamic D2 receptors on leptin and glucose concentration
Introduction: A specific role of dopamine D2 receptor signaling of midbrain and hypothalamic dopaminergic systems has not been yet identified in energy homeostasis. Here, we investigated effects of intra-ventromedial hypothalamus (VMH) administration of the D2 receptor agonist (quinpirole) and antagonist (sulpiride) on plasma leptin and glucose levels in fasted rats. Methods: A guide cannul...
[ 5 ] - Effects of amitriptyline and fluoxetine on synaptic plasticity and TNF-α level at hippocampus of streptozotocin-induced diabetic rats
Introduction: Studies have indicated that diabetes mellitus impairs hippocampus. Diabetes increases the risk of depression and treatment with antidepressants may affect learning and memory. The aim of this study was to evaluate the effects of amitriptyline and fluoxetine on synaptic plasticity and TNF-α level in the hippocampus of streptozotocin-induced diabetic rats. Methods: Experimenta...
[ 6 ] - Effects of doxepin on spatial memory, TNF-α and Bcl-2 family genes expression in rat hippocampus
Introduction: Although the initial hypothesis for the action of doxepin was based on the inhibition of the reuptake of neurotransmitters, it has been suggested that it may also involve other mechanisms. Therefore, this study aims to investigate the effect of doxepin on spatial memory, tumor necrosis factor alpha (TNF-&alpha) level, expression of pro-apoptotic (Bad and Bax) and anti-apoptotic (B...
[ 7 ] - Effect of forced treadmill exercise on long-term potentiation (LTP) in the dentate gyrus of hippocampus in male rats
Introduction: Previous studies indicate that exercise influences cognitive function. Nevertheless, considering that exercise in animal study can be voluntary, or forced, effects of exercise (specially forced exercise) on learning and memory abides as a matter of controversy. The present study aimed to investigate the effects of treadmill exercise on LTP in the dentate gyrus of rats. Methods: T...
[ 8 ] - Cholinergic Differentiation of neural precursor cells derived from mouse embryonic stem cells increased by Shh, LIF and RA
Introduction Cholinergic system is one of the important systems of mammalian CNS. Cholinergic neurons distributed in brain and spinal cord and contributed to principal functions like: consciousness, learning and memory, and motor control. In this study we investigated the differentiation potentiality of mouse embryonic stem cells toward cholinergic neurons. The aim of this study was to evaluate...
[ 9 ] - مقایسة تأثیر استرس محدودیت حرکتی بر یادگیری و حافظة فضایی رتهای نر پیر و جوان
هدف پژوهش حاضر، بررسی تأثیر استرس محدودیت حرکتی بر یادگیری و حافظة فضایی رتهای نر پیر و جوان بود. تعداد 24 رت نر نژاد ویستار از پژوهشکدة رویان اصفهان در دو گروه سنی سه‌ماهه (جوان) و 12 ماهه (پیر) انتخاب شدند و براساس وزن در چهار گروه شش‌تایی تقسیم شدند. پس از یک هفته سازگاری با محیط لانه و تردمیل، هر گروه با توجه به برنامة خاص خود شامل، گروه استرس محدودیت حرکتی (روزی دو ساعت به‌مدت هفت روز) ...
[ 10 ] - Effect of intracerebroventricular injection of GABA receptors antagonists on morphine-induced changes in GABA and GLU transmission within the mPFC: an in vivo microdialysis study
Objective(s): Many studies have focused on ventral tegmental area than of other mesocorticolimbic areas, and implicated a key role for the medial prefrontal cortex (mPFC) in the development of addictive behaviors. So far, the role of gamma-aminobutyric acid (GABA) receptors in the discriminative properties of morphine has received little attention and few studies evaluated the role of these rec...
[ 11 ] - Effects of crocin on cognitive and spatial memories in rats under chronic isolation stress
Introduction: Certain types of chronic mental stress impair memory. On the other hand, crocin is introduced in the medical literature as an effective component of saffron with remedial effects on memory impairment. This study investigated the effects of crocin on spatial and cognitive memories, locomotor activity, novel recognition conditions and serum corticosterone levels in rats under chroni...
[ 12 ] - Effects of Boswellia serrata resin extract on motor dysfunction and brain oxidative stress in an experimental model of Parkinson’s disease
Objective:Boswellia serrata oleo-gum resin (frankincense) exerted antioxidant and anti-inflammatory effects against several diseases, such as; asthma, rheumatoi...
[ 13 ] - Neuroprotective effects of endurance training in 6-hydroxydopamine rat model of Parkinson’s disease
Introduction: Parkinson’s disease (PD) is characterized by progressive dopamine depletion in the striatum, and leads to mitochondrial and motor disorders. The present study investigated the effect of moderate endurance training on motor disorder and mRNA expression of PPAR-γ, PGC-1α and BDNF in 6-hydroxydopamine (6-OHDA) rat model of PD Materials and Methods: Thirty two male Wistar rats were di...
[ 14 ] - The Protective Effects of Crocin on Input-Output Functions and Long-term Potentiation of Hippocampal CA1 Area in Rats Exposed to Chronic Social Isolated Stress
Introduction: The lack of social communication is associated with the primary risk of proper brain functions. It is reported that crocin helps relieve this problem. The present study examined the protective effect of two doses of crocin on Long-term potentiation (LTP) of hippocampal cornu ammonis 1 (CA1) area as a cellular mechanism in rats exposed to chronic social isolated stress. Methods: R...
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