Seyed Mahmoud Hosseini
Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
[ 1 ] - Thymoquinone restores liver fibrosis and improves oxidative stress status in a lipopolysaccharide-induced inflammation model in rats
Objective: Liver fibrosis is the primary sign of chronic liver injury induced by various causes. Thymoquinone (TQ) is the major ingredient of Nigella sativa with several beneficial effects on the body. In the present study, we aimed to investigate the effect of TQ on liver fibrosis in a lipopolysaccharide (LPS)-induced inflammation in male rats. Materials and methods: Fifty male Wistar rats wer...
[ 2 ] - Preventive effect of Coriandrum sativum on neuronal damages in pentylentetrazole-induced seizure in rats
Objective:Coriandrum sativum (C. sativum) as a medicinal plant has been pointed to have analgesic, hypnotic and anti-oxidant effects. In the current study, a possible preventive effect of the hydro-alcoholic extract of the plant on neuronal damages was examined in pentylenetetrazole (PTZ) rat model of seizure.Materials and Methods: Forty male rats were divided into five main groups and treated ...
[ 3 ] - The effects of different fractions of Coriandrum sativum on pentylenetetrazole-induced seizures and brain tissues oxidative damage in rats
Objective: In the present work, the effects of different fractions of Coriandrum sativum (C. sativum), on pentylenetetrazole (PTZ)-induced seizures and brain tissues oxidative damage were investigated in rats. Materials and Methods: The rats were divided into the following groups: (1) vehicle, (2) PTZ (90 mg/kg), (3) water fraction (WF) of C. sativum (25 and 100 mg/kg), (4) n-butanol fraction (...
[ 4 ] - The effects of Nigella sativa on sickness behavior induced by lipopolysaccharide in male Wistar rats
Objective: Neuroimmune factors contribute on the pathogenesis of sickness behaviors. Nigella sativa (NS) has anti-inflammatory, anti-anxiety and anti-depressive effects. In the present study, the effect of NS hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (LPS) was investigated. Materials and Methods: The rats were divided into five groups (n=10 in each): (1) control...
[ 5 ] - Neuropharmacological effects of Nigella sativa
Nigella sativa (NS) (Ranunculaceae family) is generally utilized as a therapeutic plant all over the world. The seeds of the plant have a long history of use in different frameworks of medicines and food. In Islamic literature, it is considered as one of the greatest forms of therapeutics. It has been widely used to treat nervous system diseases such as memory impairment, epilepsy, neurotoxicit...
[ 6 ] - The effects of Crocus sativus (saffron) and its constituents on nervous system: A review
Saffron or Crocus sativus L. (C. sativus) has been widely used as a medicinal plant to promote human health, especially in Asia. The main components of saffron are crocin, picrocrocin and safranal. The median lethal doses (LD50) of C. sativus are 200 mg/ml and 20.7 g/kg in vitro and in animal studies, respectively. Saffron has been suggested to be effective in the treatment of a wide range of d...
[ 7 ] - Anticonvulsant and neuroprotective effects of Rosa damascena hydro-alcoholic extract on rat hippocampus
Objective: Previously, analgesic, hypnotic, and anticonvulsant effects have been suggested for Rosa damascena (R. damascena). In the present study, possible anti-seizure and neuro-protective effects of hydro-alcoholic extract of R. damascena has been investigated after inducing seizures in rats by pentylenetetrazole (PTZ). Materials and Methods: The rats were divided to five groups: (1) Control...
[ 8 ] - The role for nitric oxide on the effects of hydroalcoholic extract of Achillea wilhelmsii on seizure
Objective: Nitric oxide (NO) plays an important role both as a consequence and as a cause of epileptic seizures.Regarding the central nervous system depressant effects of Achillea wilhelmsii (A. wilhelmsii), as well the effects of the plant on NO, this study was aimed to elucidatethe possible role for nitric oxide on the effects of hydroalcoholic extract of A. wilhelmsii on pentylenetetrazole (...
[ 9 ] - Analgesic effect of the aqueous and ethanolic extracts of clove
Objective: The beneficial effects of clove on toothache have been well documented. We have also previously shown the analgesic effects of clove essential oil. The present work was done to investigate the analgesic effects of the aqueous extract of clove using hot plate test. The possible role of opioid receptors in the analgesic effects of clove was also investigated using naloxone. Materials a...
[ 10 ] - Analgesic effect of clove essential oil in mice
Objective: Results obtained from literature reviews and human studies have shown the analgesic effects of clove plant in toothache. The present work was undertaken in order to investigate the possible analgesic effect of clove oil in mice. Materials and Methods: Fifty mice were divided into 5 groups: 1) Saline; 2) Essential oil (Ess) 2%, 3) Ess 5%, 4) Ess10% and 5) Ess 20%. The hot plate test ...
[ 11 ] - Evaluation of nicotinic receptor of pedunculopontine tegmental nucleus in central cardiovascular regulation in anesthetized rat
Objective(s): Cholinergic neurons are important neurons in the Pedunculopontine tegmental nucleus (PPT). In this study, nicotinic receptor of the PPT in central cardiovascular regulation in the anesthetized rat was evaluated. Materials and Methods: Saline, acetylcholine (Ach; doses: 90 and 150 nmol), hexamethonium (Hexa; doses: 100 and 300 nmol) and higher doses of Hexa (300 nmol) + Ach (150 nm...
[ 12 ] - The role of local renin-angiotensin system on high glucose-induced cell toxicity, apoptosis and reactive oxygen species production in PC12 cells
Objective(s): Hyperglycemia, oxidative stress and apoptosis have key roles in pathogenesis of diabetic neuropathy. There are local renin-angiotensin systems (RASs) in different tissues such as neural tissue. Local RASs are involved in physiological and pathophysiological processes such as inflammation, proliferation and apoptosis. This study aimed to investigate the role of local renin-angioten...
[ 13 ] - The Effects of Nigella Sativa Hydro-alcoholic Extract on Memory and Brain Tissues Oxidative Damage after Repeated Seizures in Rats
Regarding the therapeutic properties of Nigella sativa (NS), the effects of the plant hydro – alcoholic extract on learning, memory and brain tissues oxidative damage were investigated in penthylenetetrazole (PTZ) - induced repeated seizures.There were 4 experimental groups including: 1- control group; received saline, 2- PTZ group ; received saline and PTZ (50 mg/kg, i.p) , 3-PTZ- NS 200 and 4...
[ 14 ] - Protective effects of Nigella sativa on synaptic plasticity impairment induced by lipopolysaccharide
In the present study the protective effect of Nigella sativa (N. sativa)on synaptic plasticity impairment induced by lipopolysaccharide (LPS) in rats was investigated. Fifty-eight rats were grouped and treated as follows: 1) control (saline), 2) LPS, 3) LPS-N. sativa,and 4) N. sativa. In a Morris water maze test, the escape latency and traveled path to find t...
[ 15 ] - The Effects of Nigella Sativa Hydro-alcoholic Extract on Memory and Brain Tissues Oxidative Damage after Repeated Seizures in Rats
Regarding the therapeutic properties of Nigella sativa (NS), the effects of the plant hydro – alcoholic extract on learning, memory and brain tissues oxidative damage were investigated in penthylenetetrazole (PTZ) - induced repeated seizures.There were 4 experimental groups including: 1- control group; received saline, 2- PTZ group ; received saline and PTZ (50 mg/kg, i.p) , 3-PTZ- NS 200 and 4...
[ 16 ] - P45: The Effects of Nigella sativa on Sickness Behavior Induced by Lipopolysaccharide in Male Wistar Rats
Neuroimmune factors contribute on the pathogenesis of sickness behaviors. Nigella sativa (NS) has anti-inflammatory, anti-anxiety and anti-depressive effects. In the present study, the effect of NS hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (LPS) was investigated. The rats were divided into five groups (n=10 in each): (1) control (saline), (2) LPS (1 mg/kg, admin...
[ 17 ] - P151: The Effects of Boswellia Serrate on Central Nervous System
In the process of neuronal inflammation, an increased in inflammatory cytokines (IL-1β, IL-6 and TNF-α) from immune cells (leukocytes and macrophages), brain cells (microglia, astrocytes and neurons) and in hippocampus, amygdala occurs. Raise the level of cytokines result in reduced in production of molecules that are related to plasticity, especially BDNF, IGF-1 and VEGF. Microglia ...
[ 18 ] - مقایسۀ یادگیری فضایی موشهای صحرایی نر، ماده و اوارکتومی شده
مقدمه: تفاوت وابسته به جنس در رفتار حیوانات و انسان به طور قابلتوجهی مورد بررسی قرار گرفته است. گزارشهای بحثبرانگیزی در مورد نقش هورمونهای جنسی در حافظه و یادگیری وجود دارد. در مطالعۀ حاضر یادگیری فضایی بین موشهای صحرایی نر، ماده و اوارکتومی شده با استفاده از آزمون ماز آبی موریس مورد مقایسه قرار گرفت. مواد و روشها: در این پژوهش 24 سر موش صحرایی به سه گروه نر، ماده و اوارکتومی شده تقسیم شد...
[ 19 ] - توانایی سلولهای بنیادی در درمان بیماریهای سیستم عصبی
مقدمه: سلولهای بنیادی سلولهای تمایزنیافتهای هستند که توانایی تولید انواع مختلفی از سلولها را در بدن دارند. یک طیف وسیعی از اطلاعات توانایی درمان سلول بنیادی را برای انواع بیماریهای عصبی نشان میدهند. در این مقالۀ مروری اثرات مفید احتمالی سلولهای بنیادی برای درمان بیماریهای سیستم عصبی ارائه شدند. سلولهای بنیادی برای درمان بیماریهای مختلف حاد و مزمن سیستم عصبی نظیر سکتۀ مغزی خونریزی دهند...
[ 20 ] - بررسی اثر عصارۀ هیدروالکلی سیاهدانه بر اختلال حافظۀ فضایی القاء شده به وسیلۀ تشنج در موش صحرایی
مقدمه: پیشنهاد شده است که حملات تشنجی مکرر منجر به تخریب نورونهای هیپوکامپ و اختلال حافظه میشود. برخی اثرات درمانی از قبیل ضد دردی، حفاظت نورونی، آنتی اکسیدانی و ضد تشنجی برای سیاهدانه گزارش شده است. در مطالعۀ حاضر، اثرات عصارۀ هیدروالکلی سیاهدانه بر اختلال حافظۀ فضایی ناشی از تشنجهای ایجاد شده توسط پنتیلن تترازول (PTZ) در موش صحرایی بررسی شد. مواد و روشها: موشهای صحرایی نر نژاد ویستار به ...
[ 21 ] - اثرات والپروات سدیم بر روند یادگیری و حافظه در مدل تری متیل تینی بیماری آلزایمر
مقدمه: تری متیل تین (TMT) به عنوان یک ترکیب نوروتوکسیک به خصوص در هیپوکامپ عمل میکند و در نتیجه موجب اختلالات شناختی و حافظه در انسان و حیوانات میشود. اثرات مفید والپروات سدیم (VPA) در عملکردهای شناختی مغز نیز پیشنهاد شده است. در مطالعۀ حاضر اثر VPA در نقایص یادگیری و حافظۀ ناشی از تری متیل تین در موشهای صحرایی، با استفاده از ماز آبی موریس مورد بررسی قرار گرفت. مواد و روشها: 23 سر موش صحرای...
[ 22 ] - Brain Tissues Oxidative Damage as a Possible Mechanism of Deleterious Effects of Propylthiouracil- Induced Hypothyroidism on Learning and Memory in Neonatal and Juvenile Growth in Rats
Introduction: The role of brain tissues oxidative damage in learning and memory impairments has been well documented. It is also well known that thyroid hormones have a critical role for the brain functions. The purpose of this study was to investigate the role of brain tissues oxidative damage as a possible mechanism of deleterious effects of propylthiouracil (PTU) - induced hypothyroidism on ...
[ 23 ] - Effect of Ocimum basilicum hydro-alcoholic extract on oxidative damage of brain tissue following seizures induced by pentylenetetrazole in mice
Introduction: A relationship between epileptic seizures and brain tissue oxidative damage has been suggested. Ocimum basilicum (O. basilicum) has been shown to have beneficial effects including hypnotic and protective against tissue oxidative damage. The present study was designed to evaluate the effects of O. basilicum hydro-alcoholic extract on oxidative damage of brain tissue following s...
[ 24 ] - The effects of captopril on lipopolysaccharide-induced sickness behaviors in rats
Neuro-immune mediators play an important role in the development of sickness behaviors. In the present study, the effect of captopril on sickness behaviors caused by lipopolysaccharide (LPS) was studied in the rats. The animals were randomized into the following groups: control, sham, 10 mg kg-1 captopril - LPS (Capto 10-LPS), 50 mg kg-1 captopril - LPS (Capto 50-LPS), and...
[ 25 ] - The effects of PPAR-γ agonist pioglitazone on hippocampal cytokines, brain-derived neurotrophic factor, memory impairment, and oxidative stress status in lipopolysaccharide-treated rats
Objective(s): The aim of current study was to evaluate improving effects of pioglitazone as an agonist of peroxisome proliferator-activated receptor gamma (PPARγ), on brain-derived neurotrophic factor (BDNF) and cytokines as well as tissue oxidative damage criteria in the hippocampus in a rat model of lipopolysaccharide (LPS) induced memory impairment.<strong...
[ 26 ] - The Effects of Inactivation of Pedunculopontine Tegmental Nucleus by Cobalt (II) Chloride on Cardiovascular Responses in Hemorrhagic Hypotensive Rats
Introduction: Based on the evidence, the Pedunculopontine Tegmental nucleus (PPT) is involved in cardiovascular function regulation. In this study, the probable role of PPT on cardiovascular parameters in the hypotension induced by Hemorrhage (HEM) was evaluated. Methods: The study rats were divided up into 5 groups: 1. Control (Saline); 2. Cobalt(II) chloride (CoCl2); 3. HEM; 4. Saline+HEM; ...
[ 27 ] - Zataria multiflora extract reverses lipopolysaccharide-induced anxiety and depression behaviors in rats
Objective: Stressors have an important role in sickness behaviors. We checked the effect of Zataria multiflora (ZM) extract against lipopolysaccharide (LPS)-induced anxiety and depression behaviors in rats. Material and Methods: Rats were distributed in the following groups (n=10): Control, LPS (1 mg/kg), LPS-ZM50, LPS-ZM100 and LPS-ZM200. LPS was syringed intraperitoneally (ip) 2 hr bef...
[ 28 ] - Cardiovascular effects of standardized hydroalcoholic extract of Ribes khorasanicum fruit in acute hypertensive rats
Objective: Ribes khorasanicum (R. khorasanicum)traditionally has been used for the treatment of higher blood pressure. In this study, the effect of hydroalcoholic extract of R. khorasanicum fruit in normotensive and hypertensive rats was evaluated. Materials and Methods: Animals were assigned into the following groups: 1) Control, 2) AngII (50 ng/kg), 3) ...
[ 29 ] - The effects of lettuce extract on the level of T4, memory and nerve conduction velocity in male rats
Objective: According to the traditional medicine,lettuce can affect nerve conduction velocity and memory. So, to investigate the effect of lettuce seeds extract on body activities, lettuce seeds were used. Materials and Methods: In the present study, the effects of lettuce (Lactuca sativa) seeds extract consumption (in drinking water) on T4 level...
[ 30 ] - Improving Effect of Ethyl Acetate Fraction of Tanacetum Parthenium Against Brain Oxidative Damage in Pentylenetetrazole-Induced Seizure Model In Mice
Aims: Oxidative stress plays an important role in pathogenesis of seizure. In this study the effect of ethyl acetate fraction of Tanacetum parthenium against brain oxidative damage in pentylenetetrazole-induced (PTZ) seizure model in mice was investigated. Materials and methods: In this experimental study, mice were distributed into 6 groups: 1) Control, 2) PTZ, 3-6) Fraction+PTZ. The animals ...
[ 31 ] - Suppressive Effects of the Aerial Parts of Datura Stramonium L. Extract on Naloxone-Precipitated Morphine Withdrawal Signs in Mice
Background and Objective: Datura stramonium L. is a medicinal herb from the family of Solanaceae. It has been used in herbal remedies for promoting health and treating several diseases. The current study was set up to compare the effects of Datura stramonium L. extract on the naloxone-precipitated opiate-withdrawal in mice. Materials and Methods: Male BALB/c mice (30–35 g, n = 40) were arbitra...
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