Ali Mandegary
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Science, Kerman, Iran
[ 1 ] - Early and late preventive effect of Nigella sativa on the bleomycin-induced pulmonary fibrosis in rats: An experimental study
Objective: Pulmonary fibhrosis is a disease of the connective tissues in the respiratory system. Nigella sativa has been used for the treatment of pulmonary diseases like asthma. This study investigated the early and late preventive effect of methanolic extract of N. sativa on a bleomycin- induced pulmonary fibrosis model. Materials and Methods: This study was carried out using 52 rats. Pulmona...
[ 2 ] - Cyclooxygenase inhibitors combined with deuterium-enriched water augment cytotoxicity in A549 lung cancer cell line via activation of apoptosis and MAPK pathways
Objective(s): Combination chemotherapy is a rational strategy to increase patient response and tolerability and to decrease adverse effects and drug resistance. Recently, the use of non-steroidal anti-inflammatory drugs (NSAIDs) has been reported to be associated with reduction in occurrence of a variety of cancers including lung cancer. On the other hand, growing evidences suggest that deuteri...
[ 4 ] - Zataria multiflora Boiss. extract improves spatial memory and learning capacity in scopolamine-induced amnesic rats
Objective: Zataria multiflora (Zm) has been proposed for memory enhancing in Persian traditional medicine; but to now, no study has been carried out in this field yet. The aim of this research was to study the plant effect on spatial memory in scopo...
[ 5 ] - Malathion-increased Hepatotoxicity in Diabetic Rats
Background: Malathion (MT), an organophosphorus pesticide, induces hepatotoxicity and is associated with hyperglycemia and the development of diabetes mellitus. Objectives: This study was aimed to evaluate the effects of sub-acute exposure to sub-lethal dose of MT in the liver of diabetic rats. Methods: Non-diabetic and streptozotocin-induced diabetic rats received MT at a dose of 150 mg/kg...
[ 6 ] - An Standardized Extract From Textured Soy Protein (Glycine Max L.) Has Ameliorating Effect on Memory Deficit and Learning Insufficiency in Scopolamine-Induced Amnesia
Purpose of the Study: Textured soy protein (TSP) and Ajil are two processed forms of soybean (Glycine max L.) which are widely consumed by Iranian for nutritional purpose. Recently, we have reported antioxidant and anticholinesterse effect of raw soybean (RS) which has been attributed to isoflavones such as genistein. In this work, we aimed to compare in vitro antioxidant and antichoinesterase ...
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