mohammad ghannadi-maragheh

Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran

[ 1 ] - Production, biodistribution assessment and dosimetric evaluation of 177Lu-TTHMP as a bone pain palliation agent

Objective(s): Recently, bone-avid radiopharmaceuticals have been shown to have potential benefits for the treatment of widespread bone metastases. Although 177Lutriethylene tetramine hexa methylene phosphonic acid (abbreviated as 177Lu- TTHMP), as an agent for bone pain palliation, has been evaluated in previous studies, there are large discrepancies between the obtained results. In this study,...

[ 2 ] - Preclinical studies of 166Ho-chitosan for treatment of hepatocellular carcinoma

Introduction: Recently, due to the special characteristics of 166Ho and chitosan, 166Ho-chitosan complex was developed for treatment of tumors such as hepatocellular carcinoma. This complex has been lately prepared with high radiochemical purity in our lab. The preclinical studies of the complex however should be performed to evaluate the tracer concentration in target and...

[ 3 ] - Preparation and quality control of 177Lu-chitosan for radiosynovectomy

Introduction: Rheumatoid arthritis (RA) is the most common autoimmune disease, leading to the destruction of the joints and causing pain, disability, and immobility in the patients. Radiosynovectomy (RSV) has been applied as an effective treatment for the patients with resistant synovitis after failure of long-term pharmacotherapy and intra-articular steroid injection for more than 50 years. Se...

[ 4 ] - Radiosynthesis of 191Os-2-acetylpyridine thiosemicarbazone complex, as an in vivo therapeutic radionuclide generator

Introduction: Due to the anti-proliferative properties of platinum group-thiosemicarbazone complexes, the production of 191Os-labeled 2-acetyl pyridine 4-N-methylthiosemicarbazone (191Os-APMTS) was investigated. Methods: [191Osmium (T½= 15.4d) was produced via the 190Os(n,γ)191Os nuclear reaction using enriched target irradiated...

[ 5 ] - Preparation and quality control of scandium-46 bleomycin as a possible therapeutic agent

Introduction: Due to interesting therapeutic properties of 46Sc and antineoblastic antibiotic, bleomycin (BLM), 46Sc-bleomycin (46Sc-BLM) was developed as a possible therapeutic compound. Methods: In this work, Sc-46 chloride was obtained by thermal neutron flux (4 × 1013 n.cm-2.s-1) of natural metallic scandium sample followed ...

[ 6 ] - محاسبات آهنگ دز ناشی از پرتوزایی طبیعی موجود در سنگ‌های گرانیتی ساختمانی در ایران

All building materials contain various amounts of natural radioactive nuclides. Materials derived from rock and soil contain mainly natural radionuclides of the uranium (238U) and thorium (232Th) series, and the radioactive isotope of potassium (40K). Radiation exposure due to building materials can be divided into external and internal exposure. The external exposure is caused by direct gamma ...

[ 7 ] - بررسی پویایی اجزای فیزیکی کربن آلی خاک‌دانه‌های پایدار در انواع مختلف کاربری اراضی

در این تحقیق افق‌های مشابه (A، AB، B1) از کاربری‏های جنگل پهن‏برگ، جنگل سوزنی‏برگ، و مرتع انتخاب و درصد خاک‌دانه ‏های پایدار در آب آن‌ها تعیین شد. در هر یک از کلاس‏های خاک‌دانه ‏های پایدار افق A، مقادیر قطعات مواد آلی آزاد، بخش درون‏ خاک‌دانه ‏ای، و کمپلکس‏های رس+سیلت بر حسب چگالی و اندازه تعیین و مقدار کربن و نیتروژن آن‌ها با دستگاه تجزیة عنصری CHN اندازه‏گیری شد. در هر نوع کاربری غالباً با کاه...

[ 8 ] - Novel 175Yb-Poly (L-lactic acid) microspheres for transarterial radioembolization of unrespectable hepatocellular carcinoma

Novel biodegradable Poly (L-lactic acid) (PLLA) microspheres containing ytterbium were designed for intra-tumoral radiotherapy, especially for radioembolization. 175Yb possess both therapeutic beta and diagnostic gamma radiations. In this work, process to make ready radiomicrospheres 175Yb(acac)3-loaded PLLA for more consideration has been investigated. The radiomicrospheres were prepared with ...