N. Mohamadpour Dounighi

[ 1 ] - Design and evaluate alginate nanoparticles as a protein delivery system

In recent years, encapsulation of drugs and antigens in hydrogels, specifically in calcium alginate particles, is an interesting and practical technique that was developed widespread. It is well known that alginate solution, under proper conditions, can form suitable nanoparticles as a promising carrier system, for vaccine delivery. The aim of this study was to synthesis alginate nanoparticles ...

[ 2 ] - A New Approach to Antivenom Preparation Using Chitosan Nanoparticles Containing Echis Carinatus Venom as A Novel Antigen Delivery System

In recent years, use of biodegradable polymers based nanoparticles has received highinterest in the development of vaccines delivery vehicles. The aim of study was to preparechitosan nanoparticles (CS NPs) for loading Echis carinatus (EC) venom and evaluate theirpotential as an adjuvant and antigen delivery system on a pilot scale. CS NPs were preparedusing ionic gelation method, and their char...

[ 3 ] - Preparation and Characterization of Agkistrodon Halys Venom Entrapped Chitosan Nanoparticles: Novel and Advanced Antigen Delivery and Adjuvant System

Background & Aims: In recent years, the feasibility of hydrophilic nanoparticles has been broadly investigated for use in drug delivery and therapeutic systems. Due to the problems of traditional adjuvants, in this study Agkistrodon halys (Ah) Snake venom was loaded in chitosan nanoparticles (CS NPs) in order to be used as an advanced adjuvant and antigen delivery system in ant...

[ 4 ] - A New Approach to Antivenom Preparation Using Chitosan Nanoparticles Containing Echis Carinatus Venom as A Novel Antigen Delivery System

In recent years, use of biodegradable polymers based nanoparticles has received highinterest in the development of vaccines delivery vehicles. The aim of study was to preparechitosan nanoparticles (CS NPs) for loading Echis carinatus (EC) venom and evaluate theirpotential as an adjuvant and antigen delivery system on a pilot scale. CS NPs were preparedusing ionic gelation method, and their char...

[ 5 ] - مقایسه یاورهای نانوذره‌ای بایاور مونتاناید در بیش ایمن‌سازی برای تولید سرم ضد مارگزیدگی

زمینه و هدف: امروزه انتخاب و به‌کارگیری یاورهای نانوذره‌ای مناسب بسیار مهم است. در تهیه ضد زهر به دلیل فقدان سرم‌های ضد مارگزیدگی مؤثر برای درمان آن و هزینه‌های زیاد خرید سرم‌های ضد مارگزیدگی خارجی، اهمیت تهیه نانوذره‌های مناسب داخلی برای تولید پلاسمای بیش ایمن را دوچندان می‌کند. به‌منظور کاهش معایب یاورهای متداول و تولید ضد زهر با توانمندی بالا بین یاورهای مختلف مقایسه‌ای ازنظر توانایی تولید س...

[ 6 ] - Chitosan-based Nanoparticles in Mucosal Vaccine Delivery

Most infectious diseases are caused by pathogenic infiltrations from the mucosal tract. Nowadays, the use of vaccines has been widely investigated for the prevention of different infectious diseases, infertility, immune disorders, malignancies, and allergies. Broad-spectrum adjuvant substances have been studied for immune system stimulation with a greater efficiency against specific antigens. V...

[ 7 ] - Serological, pathological and scintigraphic assessment of Hemiscorpius lepturus effects on renal dysfunction in rats

Objective(s): Hemiscorpius lepturus is one of the dangerous scorpions of Iran leading to acute kidney injury (AKI) especially in infants. The purpose of this animal study was to compare the serological, pathological and scintigraphic data to quickly predict the occurrence of this disorder.Materials and Methods: In two groups of animals, each contained five rats, H. lepturus venom (1200 µg/Kg) w...

[ 8 ] - A comparative study on the equine and camelid antivenoms upon cardiovascular changes induced with Hemiscorpius lepturus venom in rats

Objective(s): In this study, the neutralizing abilities of the equine and the recently introduced camelid antivenoms on the hemodynamic parameters (inotropism, chronotropism, and arrhythmogenicity) were assessed following envenomation by Hemiscorpius lepturus venom in rats. Materials and Methods: At first, the electrophoretic profiles of...

[ 9 ] - Purification and characterization of a novel type of neurotoxic peptides from the venom of the Iranian scorpion Hemiscorpius lepturus

Objective(s): Scorpion venom has toxic effects on mammals, insects and crustaceans. Toxicogenic peptides are major contributors to the scorpion venom, which make it toxic. The Hemiscorpius lepturus (H. lepturus) is one of the most common scorpion bites agent, and responsible for 95% of scorpion bite deaths cases in Iran.Materials and Methods:</strong...

[ 10 ] - Characterizing and controlling the loading of Vipera albicornuta venom in chitosan nanoparticles as an adjuvant and vaccine delivery system

The aim of this study was designing and preparing the chitosan nanoparticles (CS-NPs) loading with snake (Vipera albicornuta) venom as well as evaluating the influence of different factors on the encapsulation efficiency (EE) and loading capacity (LC) of venom. The morphologies and characteristics of CS-NPs were determined by scanning electron microscopy (SEM), Fourier transform infrared spectr...