Somayeh Makarem
Department of chemistry, Karaj branch, Islamic Azad University, Karaj, Iran.
[ 1 ] - Electro-Organic Synthesis: An Efficient Method for the Preparation of Nanosized Particles of Phthalazine Derivatives via One-Pot Multicomponent Reactions
Aza heterocyclic compounds are major interest for organic chemists because of their mainly pharmacological activities and clinical applications such as antianxiety, antitumor, anticonvulsant, cardiotonic and vasorelaxant. This contribution describes an electrochemical approach for the preparation of nanosized particles of phthalazine in high yields and very short reaction time. The method is ba...
[ 2 ] - Synthesis and Molecular Docking studies of Some Tetrahydroimidazo[1,2-a] pyridine Derivatives as Potent α-Glucosidase Inhibitors
KAl(SO4)2.12H2O is found to efficiently and heterogeneously catalyze the one-pot three-component reaction of 2-(nitromethylene)imidazolidine, malononitrile and aldehydes under mild conditions to afford the corresponding tetrahydroimidazo[1,2-a]pyridine in good yields and short reaction times. Docking study of some compounds in the active site of α-glucosidase demonstrated that these...
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