مریم رفیعی راد

[ 1 ] - بررسی اثر تجویز درون صفاقی عصاره هیدروالکلی گیاه چویل بر صرع ناشی از پنتیلن تترازول PTZ ) ) در موش سفید کوچک آزمایشگاهی نر

زمینه و هدف: تشنج از مهمترین علایم صرع است که به علت فعالیت الکتریکی غیرطبیعی نورونهای مغز ایجاد میشود. به دلیل عوارض جانبی داروهای شیمیایی، کاربرد داروهای گیاهی میتواند جایگزین مناسبی برای کنترل تشنج باشد. در این مطالعه اثر عصاره گیاه چویل Ferulae angulata (Schlecht) Boiss بر صرع ناشی از پنتیلن تترازول (PTZ) در موش سفید کوچک نر بررسی گردید. روش بررسی:...

[ 2 ] - Pomegranate seed hydroalcoholic extract improves memory deficits in ovariectomized rats with permanent cerebral hypoperfusion /ischemia

Objective: Estrogen deficit following menopause results in cognitive behaviors impairment. Severity of these impairments in menopause women suffer with cerebral hypo perfusion/ischemia (HI) cause the brain damage and neuronal death. This study aimed to evaluate the effects of pomegranate seed extract (PGSE) on avoidance memories after permanent bilateral common carotid arteries occlusion (2CCAO...

[ 3 ] - Tetramethylguanidiniumtriflate catalyzed Henry reaction of isatins: An efficient synthesis of 3-hydroxy-3-(nitromethyl)indolin-2-one derivatives and their anti-diabetic activity

The ionic liquid, N,N,N,N-tetramethylguanidiniumtriflate (TMGTf) was found to be an efficient catalyst solvent for Henry reaction between nitromethane and isatin derivatives to provide 3-hydroxy-3-(nitromethyl)indolin-2-one under mild conditions. The ionic liquid amenable to successive recycling without appreciable decrease in activity. Synthesized compounds have been screened for their anti-di...

[ 4 ] - The effect of Kardeh (Biarum Bovei) Hydro-alcoholic extract on pain threshold in STZ induced diabetic rats

Background & Aim: Diabetes mellitus in long-term through various means such as augmented oxidative stress is associated with disturbances such as pain and cognition in humans and laboratory animals. According to the evidence of anti-diabetic extract of Biarum Bovei (BB), Effect of oral administration of this extract was evaluated on blood glucose level and pain threshold in diabetic rats. Expe...

[ 5 ] - Effect of ellagic acid on oxidative stress duo to brain ischemia/hypoperfusion in male rat

Background & Aim: Free radicals are produced in ischemic processes. Nerve damage caused by free radicals may play a role in neurological diseases and antioxidants are protective activity. Ellagic acid is a polyphenol compound with antioxidant properties which is found in fruits like pomegranate, blackberry, and all types of mulberry. This study aimed to evaluate the effect of 14 days of oral ad...

[ 6 ] - Effect of ellagic acid on thiol levels in different brain tissue in an animal model of Parkinson's disease

Background & Aim: Parkinson's disease (PD) can be created with loss of dopaminergic substantial nigra neurons which is widely associated with oxidative stress and reduced glutathione (GSH), as the most important and abundant thiol in tissues and one of the antioxidant defense, is one of the earliest biochemical events related to Parkinson's and consumption of antioxidants has a protective effec...

[ 7 ] - Effects of Ferulago angulata Extract Against Oxidative Stress Induced by 6-hydroxydopamine in Rats

Background: Parkinson's disease is one of the prevalent degenerative diseases of the neural system. Oxidative stress, which has been recognized as the most important factor of Parkinson's disease, plays a main role in the death of neurons in this disease. Antioxidants have a proved role in the prevention of oxidative stress. Objective: Considering the presence of evidence regarding antioxid...

[ 8 ] - بررسی اثر هم زمان نانوذرات اکسید روی و ویتامین C بر استرس اکسیداتیو در مخچه موش صحرایی

سابقه و هدف: در سال های اخیر به تاثیرات بالقوه مواد در ابعاد نانو روی سیستم عصبی مرکزی توجه بیشتری شده است. مخچه یکی از مناطق مغزی با جذب بالای روی می باشد. هدف از این مطالعه بررسی اثرات نانواکسید روی بر شاخص های استرس اکسیداتیو مخچه موش های صحرایی در حضور و غیاب ویتامین C میباشد. مواد و روش ها: در این تحقیق تجربی موش های صحرایی نر نژاد ویستار (g250-200) به گروه های زیر (7=n) تقسیم شدند...

[ 9 ] - اثر تجویز درون صفاقی ویتامین ب3 (نیاسین) بر مدل افسردگی پس از زایمان در موش های سوری ماده بالغ

زمینه و هدف: افسردگی پس از زایمان یک اختلال خلقی است که می‌تواند در طول یک سال پس از زایمان رخ دهد و مادر و حتی نوزاد را تحت تأثیر قرار دهد. داروهای ضدافسردگی به دلیل داشتن عوارض جانبی به ویژه در مادران شیرده، نگران کننده هستند. ویتامین ب3 بر سنتز سروتونین تأثیر دارد و عوارض جانبی برای مصرف مقادیر کم آن گزارش نشده است. بنابراین اثر تجویز نیاسین بر مدل افسردگی پس از زایمان در موش‌های سوری ماده ط...

[ 10 ] - بررسی اثر عصاره هسته انار بر استرس اکسیداتیو ناشی از ایسکمی/هیپوپرفیوژن در بافت هیپوکامپ موش

مقدمه: رادیکال های آزاد در ایجاد و تشدید بیماری های عصبی نقش دارند و آنتی اکسیدان ها نقش محافظتی دارند. در این مطالعه اثر تجویز خوراکی عصاره هسته انار(PGSE) بر میزان پراکسیداسیون لیپیدی و اندازه گیری میزان گروه های تیول(-SH) در مدل حیوانی ایسکمی هیپوپرفیوژن مزمن مورد بررسی قرار گرفت. مواد و روش ها: موش ها به صورت تصادفی به سه گروه کنترل، گروه ایسکمی وگروه ایسکمی دریافت کننده عصاره هسته انار ت...

[ 11 ] - اثر عصاره هیدروالکلی گیاه چویل بر اختلالات حرکتی و حافظه، در مدل حیوانی بیماری پارکینسون

زمینه و هدف: بیماری پارکینسون بر اثر از بین رفتن سلول‌‌های ترشح‌کننده ماده‌ای به‌نام دوپامین ایجاد می‌شود. ﺑﺎ ﺗﻮﺟﻪ ﺑﻪ ﺧﺎﺻﻴﺖ آنتی‌اکسیدانی ﮔﻴﺎه چویل، مطالعه ﺣﺎﺿﺮ با هدف ﺑﺮرﺳﻲ اﺛﺮ ﻋﺼﺎره این گیاه بر اختلالات حرکتی و حافظه در ﻣﺪل حیوانی ﺑﻴﻤﺎری ﭘﺎرﻛﻴﻨﺴﻮن انجام شد. روش بررسی: در این مطالعه تجربی، 40 سر موش صحرایی نر نژاد ویستار (250-200 گرم) به پنج گروه شامل: 1-کنترل؛ 2-پارکینسونی‌شده و 3-گروه‌های پا...

[ 12 ] - Effects of Antidepressants Hydro-alcoholic extract of Chevilan (Ferulago angulate) in model of ischemia/ hypoperfusion in adult male rats

In patients with cerebral ischemia, both during hospitalization and in the community, the prevalence of major depression is evident. Since the depression has a negative impact on recovery, its timely diagnosis and treatment is essential. This study aimed to evaluate the effect of the oral administration of Chevilan extract (Ferulago angulata hydroalcoholic extract; 100, 200 and 400 mg/kg) on br...

[ 13 ] - Tetramethylguanidiniumtriflate catalyzed Henry reaction of isatins: An efficient synthesis of 3-hydroxy-3-(nitromethyl)indolin-2-one derivatives and their anti-diabetic activity

The ionic liquid, N,N,N,N-tetramethylguanidiniumtriflate (TMGTf) was found to be an efficient catalyst solvent for Henry reaction between nitromethane and isatin derivatives to provide 3-hydroxy-3-(nitromethyl)indolin-2-one under mild conditions. The ionic liquid amenable to successive recycling without appreciable decrease in activity. Synthesized compounds have been screened for their anti-di...

[ 14 ] - Comparison of Alphapinene and Donpezil Effects on Passive Avoidance Memory in Adult Male Rats

Background and Objectives: Alphapinene as one of the most important Components of essential oils, which has antioxidant and anti-cholinesterase activities. Oxidative stress directly affects the function of the brain and causes memory impairment. In this research, the effect of alphapinene on passive avoidance memory and oxidative stress, was investigated in comparison with donepezil. Methods...

[ 15 ] - The effect of Kardeh (Biarum Bovei) Hydro-alcoholic extract on pain threshold in STZ induced diabetic rats

Background & Aim: Diabetes mellitus in long-term through various means such as augmented oxidative stress is associated with disturbances such as pain and cognition in humans and laboratory animals. According to the evidence of anti-diabetic extract of Biarum Bovei (BB), Effect of oral administration of this extract was evaluated on blood glucose level and pain threshold in diabetic rats. Expe...

[ 16 ] - Effect of ellagic acid on oxidative stress duo to brain ischemia/hypoperfusion in male rat

Background & Aim: Free radicals are produced in ischemic processes. Nerve damage caused by free radicals may play a role in neurological diseases and antioxidants are protective activity. Ellagic acid is a polyphenol compound with antioxidant properties which is found in fruits like pomegranate, blackberry, and all types of mulberry. This study aimed to evaluate the effect of 14 days of oral ad...

[ 17 ] - Effect of ellagic acid on thiol levels in different brain tissue in an animal model of Parkinson's disease

Background & Aim: Parkinson's disease (PD) can be created with loss of dopaminergic substantial nigra neurons which is widely associated with oxidative stress and reduced glutathione (GSH), as the most important and abundant thiol in tissues and one of the antioxidant defense, is one of the earliest biochemical events related to Parkinson's and consumption of antioxidants has a protective effec...

[ 18 ] - Effects of Four Week Consumption of Lemon (Citrus limon L.) Essential Oil with Swimming Training on Lipid Profile and Lipid Peroxidation in Adult Male Mice

Background and Objectives: Exercise is a good stimulating factor for decrease of blood lipid. Lemon (Citrus limon L.) essential oil with antioxidant properties can prevent oxidative stresses. The present study was carried out to assess effects of four-week consumption of lemon essential oil with swimming training on lipid profile and lipid peroxidation. Materials & Methods: Totally, 40 male m...

[ 19 ] - Evaluation of hydroalcoholic extract of Thyme on malondialdehyde, thiol, and glutathione peroxidase concentration in the Parkinson's model induced by 6-hydroxydopamine in adult male rats

Background: Parkinson's disease (PD) is a neuropathologic disorder caused by dopaminergic neurons degeneration in the dense part of the substantia nigra. Objective: The present study, designed to evaluate the effect of hydroalcoholic extract of thyme on malondialdehyde (MDA), thiol, and glutathione peroxidase (GPX) concentration in the PD induced by 6-hydroxydopamine in an animal model. Methods...