احمد قربانی
استادیار پژوهشی، مرکز تحقیقات فارماکولوژیک گیاهان دارویی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
[ 1 ] - اثرات عصاره آبی الکلی سیاه دانه بر بارداری در موش صحرایی
مقدمه: گیاهان دارویی منبع مهمی برای درمان بسیاری از بیماری ها هستند. اما پیش از استفاده از این گیاهان در زنان باردار باید خطر احتمالی آن‌ها بر بارداری بررسی شود. سیاه‌دانه از جمله گیاهان دارویی پر مصرف در طب سنتی است، اما شواهد کافی در مورد خطرات احتمالی آن در حاملگی وجود ندارد. مطالعه حاضر با هدف بررسی سمیت احتمالی مصرف عصاره سیاه دانه طی دوره بارداری در موش صحرایی انجام شد. روش کار: این مطالع...
[ 2 ] - اثر عصاره آبی- الکلی بنفشه و فراکسیون های آن بر تکثیر سلول های سرطان گردن رحم
مقدمه: مطالعات اخیر نشان داده اند که گیاه بنفشه حاوی تعدادی ترکیبات سیکلوتیدی است که این ترکیبات اثرات کشندگی سلولی قوی ایجاد می کنند. مطالعه حاضر با هدف بررسی اثر عصاره آبی- الکلی بنفشه و فراکسیون های آن بر تکثیر سلول های سرطان گردن رحم انجام شد. روشکار: با استفاده از دستگاه سوکسله و اتانول 70%، از قسمت های هوایی بنفشه سه رنگ، عصاره آبی- الکلی تهیه و از این عصاره، سه فراکسیون آبی، اتیل است...
[ 3 ] - Protective effect of pomegranate seed oil against H2O2 -induced oxidative stress in cardiomyocytes
Objective: It has been well documented that oxidative stress is involved in the pathogenesis of cardiac diseases. Previous studies have shown that pomegranate seed oil (PSO) has antioxidant properties. This study was designed to investigate probable protective effects of PSO against hydrogen peroxide (H2O2)-induced damage in H9c2 cardiomyocytes.Materials and Methods: The cells were pretreated 2...
[ 4 ] - Protective effect of Viola tricolor and Viola odorata extracts on serum/glucose deprivation-induced neurotoxicity: role of reactive oxygen species
Objective: Oxidative stress plays a key role in the pathophysiology of brain ischemia and neurodegenerative disorders.Previous studies indicated that Viola tricolor and Viola odorataare rich sources of antioxidants. This study aimed to determine whether these plants protect neurons against serum/glucose deprivation (SGD)-induced cell death in an in vitro model of ischemia and neurodegeneration....
[ 5 ] - Hydroalcoholic extract of needles of Pinus eldarica enhances pentobarbital-induced sleep: possible involvement of GABAergic system
Objective: Insomnia is accompanied by several health complications and the currently used soporific drugs can induce several side effects such as psychomotor impairment, amnesia, and tolerance. The present study was planned to investigate the sleep prolonging effect of Pinus eldarica. Materials and Methods: Hydroalcoholic extract (HAE) of P. eldarica, its water fraction (WF), ethyl acetate frac...
[ 6 ] - The effects of different fractions of Coriandrum sativum on pentylenetetrazole-induced seizures and brain tissues oxidative damage in rats
Objective: In the present work, the effects of different fractions of Coriandrum sativum (C. sativum), on pentylenetetrazole (PTZ)-induced seizures and brain tissues oxidative damage were investigated in rats. Materials and Methods: The rats were divided into the following groups: (1) vehicle, (2) PTZ (90 mg/kg), (3) water fraction (WF) of C. sativum (25 and 100 mg/kg), (4) n-butanol fraction (...
[ 7 ] - Safety evaluation of Phytovagex, a pessary formulation of Nigella sativa, on pregnant rats
Objective: The possible toxicity of drugs in pregnancy should be tested before their use in pregnant patients. In the present study, we aimed to evaluate the safety of phytovagex, a pessary formulation of Nigella sativa (N. sativa), which is already in clinical use for vaginal fungal infection. Materials and Methods: The pregnant rats were treated intravaginal with physiological saline (vehicle...
[ 8 ] - Cancer therapy with phytochemicals: evidence from clinical studies
Cancer is still one of the major causes of mortality in both developing and developed countries. At this time, in spite of intensive interventions, a large number of patients have poor prognosis. Therefore, the effort for finding new anticancer agents with better efficacy and lesser side effects has continued. According to the traditional recommendations and experimental studies, numerous medic...
[ 9 ] - Effects of combinations of curcumin, linalool, rutin, safranal, and thymoquinone on glucose/serum deprivation-induced cell death
Objective: Several phytochemical agents have been known to exhibit a neuroprotective effect. Among them, curcumin, linalool, rutin, safranal, and thymoquinonewere widely investigated and neuroprotective activity of each of them was shown by several studies. This work was planned to investigate whether different combinations of them could induce better neuroprotective effect against glucose/seru...
[ 10 ] - In vitro assessment of alendronate toxic and apoptotic effects on human dental pulp stem cells
Objective(s): Osteonecrosis of the jaw, as an exposed necrotic bone in the oral cavity, is one of the adverse effects of bisphosphonates, which have an affinity for bone minerals. This study investigates the cytotoxic effects of alendronate (ALN) as a nitrogen-containing bisphosphonate, on human dental pulp stem cells (hDPSCs). Materials and Methods: The mesenchymal stem cells (MSCs), obtained ...
[ 11 ] - Protective Effect of Safranal, a Constituent of Crocus sativus, on Quinolinic Acid-induced Oxidative Damage in Rat Hippocampus
Objective(s): Quinolinic acid (QA)-mediated excitotoxicity has been widely used as a model for studying neurodegenerative disorders. Recent studies suggested that saffron (Crocus sativus) or its active metabolite, i.e. safranal, exerts pharmacological actions on central nervous system including anxiolytic, anticonvulsant, and neuroprotective properties. The present study aimed to investigate th...
[ 12 ] - Effect of long-term administration of Ferula gummosa root extract on serum oxidant–antioxidant status
Ferula gummosa Boiss is a good source of biologically active compounds such as monoterpene and sesquiterpene derivatives. There are also several reports on antioxidant effects of these compounds. The aim of this study was to investigate the effect of daily administration of F. gummosa root hydro-alcoholic extract on serum oxidant-antioxidant status. Twenty four Wistar rats were randomly divided...
[ 13 ] - Cytotoxic effects of auraptene against a human malignant glioblastoma cell line
Objective: Glioblastoma multiforme (GBM) is the deadliest type of primary brain tumors, and the survival of patients is estimated to be only about one year. This study, for the first time, investigated the cytotoxic effects of auraptene on U87 GBM cell line.<b...
[ 14 ] - Effect of rutin on oxidative DNA damage in PC12 neurons cultured in nutrients deprivation condition
Objective(s): Rutin is a flavonoid with potent antioxidant property, which exhibited cytoprotective effects in several models of neuronal injury. This work aimed to examine whether rutin can protect neurons against oxidative DNA damage caused by serum/glucose deprivation (SGD) as an in vitro model of neurodegeneration and ischemia. Materials and Metho...
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