فرزاد خادمی
دانشجوی دکتری تخصصی باکتری شناسی پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
[ 1 ] - کلونیزاسیون استرپتوکوکوس آگالاکتیه در زنان باردار ایران: مرور نظام‌مند
مقدمه: استرپتوکوکوس آگالاکتیه می‌تواند در رکتوواژینال زنان باردار کلونیزه شده و با انتقال به نوزاد، منجر به بیماری‌های زودرس نوزادی خطرناک مانند سپسیس و پنومونی شود. برای پیشگیری از این عوارض باید پروفیلاکسی آنتی‌بیوتیکی در مادران باردار حامل باکتری انجام شود. آمارهای متفاوتی از میزان کلونیزاسیون این باکتری در ایران وجود دارد و میزان شیوع کلی آن مشخص نیست. مطالعه مروری حاضر با هدف بررسی میزان ک...
[ 2 ] - Chitosan (CHT) and trimethylchitosan (TMC) nanoparticles as adjuvant/delivery system for parenteral and nasal immunization against Mycobacterium tuberculosis (MTb) ESAT-6 antigen
Objective(s): An efficient vaccine against TB is an urgent need. TB peptides are safe candidate but they are weak immunogens and needs to be potentiated by adjuvant/delivery systems. The main purpose of the present study was to determine the potential of CHT based NPs containing ESAT-6 antigen of M. tuberculosis for inducing mucosal and systemic immune responses after intranasal and subcutaneou...
[ 3 ] - بررسی شیوع عفونت‌های میکروبی اکتسابی از بیمارستان در بیماران بستری در قسمت‌های مختلف بیمارستان شریعتی اصفهان، 1393
زمینه و هدف: عفونت‌های بیمارستانی از مهم‌ترین مشکلات بخش سلامت خصوصأ در کشور‌های در حال توسعه است که سبب از دست دادن منابع اقتصادی، افزایش مدت زمان بستری و مرگ و میر میگردد. لذا شناخت فراوانی شیوع، شناخت فاکتور‌های خطر و بررسی راههای پیشگیری از عفونت‌های بیمارستانی دارای اهمیت ویژهای می‌باشد. هدف از مطالعه حاضر تعیین شیوع عفونت‌های بیمارستانی در بخشهای مختلف بیمارستان شریعتی اصفهان بود. رو...
[ 4 ] - رابطه کمال‌گرایی با عاطفه مثبت و منفی و افکار خودکشی در دانشجویان با گرایشات وسواسی
Background & Aim: Since suicidal ideation is a common problem in people with obsessive-compulsive tendencies, investigation of its components is of particular importance. Therefore, the aim of the present study was to investigate the relationship between perfectionism, positive and negative affection and suicidal ideation in people with obsessive tendencies. Method: This is a cross-sectional...
[ 5 ] - بررسی الگوی مقاومت آنتی‌بیوتیکی انتروکوک‌های جدا شده از نمونه‌های بیمارستان قائم مشهد
Background & Aim: Enterococci, gram-positive cocci, are important human pathogens in both community and hospital-acquired infections. Also, they are intrinsically resistant to many commonly used antimicrobial agents. The purpose of this study was to investigate antibiotic resistance profiles of Enterococci isolated from referred patients in Qaem teaching hospital. &n...
[ 6 ] - Formulation and optimization of a new cationic lipid-modified PLGA nanoparticle as delivery system for Mycobacterium tuberculosis HspX/EsxS fusion protein: An experimental design
Polymeric particles and liposomes are efficient tools to overcome the low immunogenicity of subunit vaccines. The aim of the present study was formulation and optimization of a new cationic lipid-modified PLGA nanoparticles (NPs) as a delivery system for Mycobacterium tuberculosis HspX/EsxS fusion protein. The cationic lipid-modified PLGA NPs containing HspX/EsxS fusion protein were prepared us...
[ 7 ] - Formulation and optimization of a new cationic lipid-modified PLGA nanoparticle as delivery system for Mycobacterium tuberculosis HspX/EsxS fusion protein: An experimental design
Polymeric particles and liposomes are efficient tools to overcome the low immunogenicity of subunit vaccines. The aim of the present study was formulation and optimization of a new cationic lipid-modified PLGA nanoparticles (NPs) as a delivery system for Mycobacterium tuberculosis HspX/EsxS fusion protein. The cationic lipid-modified PLGA NPs containing HspX/EsxS fusion protein were prepared us...
[ 8 ] - Enhancing immunogenicity of novel multistage subunit vaccine of Mycobacterium tuberculosis using PLGA:DDA hybrid nanoparticles and MPLA : subcutaneous administration
Objective(s): A new strategy in recent studies is using effective tuberculosis (TB) subunit vaccines combined with appropriate carriers and adjuvants which have shown promising results in preclinical and clinical studies. The aim of the present study was to evaluate the PLGA:DDA hybrid nanoparticles (NPs) for subcutaneous delivery of a novel multistage subunit vaccine ...
[ 9 ] - Prevalence of Antibiotic Resistance of Haemophilus Influenzae in Iran- A Meta-Analysis
Introduction: Based on the World Health Organization reports, infections caused by ampicillin-resistant Haemophilus influenzae strains are a major threat to public health and need urgent therapy with new antibiotics. Given the lack of a previous comprehensive study on the prevalence of the antibiotic resistance of H. influenzae in Iran, this systematic review and meta-analysis was perform...
[ 10 ] - Diversity of Toll-like Receptor Genes and Helicobacter Pylori Infections: A Meta-Analysis Study
Background and Aims: Several studies have shown that host genetic factors can be associated with the risk of developing Helicobacter pylori infections. Therefore, we evaluated the most prevalent toll-like receptors (TLRs) polymorphisms in Helicobacter pylori positive subjects and their possible role in susceptibility to Helicobacter pylori infections. Materials and Methods: Using related keywo...
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