حسن رخشنده
استادیار گروه فارماکولوژی، مرکز تحقیقات فارماکولوژیک و گیاهان دارویی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
[ 1 ] - مقایسه اثر کرم خرفه و لانولین بر درد نوک پستان زنان شیرده: کارآزمایی بالینی تصادفی شده
مقدمه: درد نوک پستان، یکی از شکایات شایع مادران در روزهای اول بعد از زایمان و دومین علت قطع زودهنگام شیردهی می‌باشد. لانولین، درمان توصیه شده جهت بهبود درد نوک پستان است. از طرفی خرفه به دلیل ترکیبات فلاونوئید و ساپونین، دارای اثرات ضد دردی و ضد التهابی ثابت شده‌ای می باشد. لذا مطالعه حاضر با هدف تعیین و مقایسه اثر کرم خرفه با لانولین بر درد نوک پستان در زنان شیرده انجام شد. روش‌کار: این مطالع...
[ 2 ] - تأثیر کپسول گرده خرما بر ارگاسم و رضایت‌مندی جنسی زنان یائسه: یک کارآزمایی بالینی دوسوکور کنترل شده
مقدمه:کاهش رضایت جنسی و فقدان ارگاسم در روابط جنسی، از مشکلات شایع زنان یائسه می‌باشد که کیفیت زندگی ایشان را تحت تأثیر قرار می‌دهد. در کتب طب سنتی گرده خرما به‌عنوان گیاه تقویت جنسی معرفی شده است و در تحقیقات اخیر باعث بهبود رفتار جنسی در حیوانات آزمایشگاهی شده است، اما پژوهشی جهت بررسی گرده خرما بر عملکرد جنسی در انسان انجام نشده است، لذا مطالعه حاضر با هدف تأثیر گرده خرما بر ارگاسم و رضای...
[ 3 ] - اثرات عصاره آبی الکلی سیاه دانه بر بارداری در موش صحرایی
مقدمه: گیاهان دارویی منبع مهمی برای درمان بسیاری از بیماری ها هستند. اما پیش از استفاده از این گیاهان در زنان باردار باید خطر احتمالی آن‌ها بر بارداری بررسی شود. سیاه‌دانه از جمله گیاهان دارویی پر مصرف در طب سنتی است، اما شواهد کافی در مورد خطرات احتمالی آن در حاملگی وجود ندارد. مطالعه حاضر با هدف بررسی سمیت احتمالی مصرف عصاره سیاه دانه طی دوره بارداری در موش صحرایی انجام شد. روش کار: این مطالع...
[ 4 ] - بررسی تأثیر کرم بابونه بر بهبود زخم اپی زیاتومی زنان نخست زا
مقدمه: اپی‌زیاتومی یکی از مداخلات پزشکی است که به منظور وسیع کردن میاندوراه به کار می رود ولی هنوز تحقیقات اندکی در زمینه مراقبت از این زخم بسیار شایع انجام شده است. عصاره بابونه به دلیل دارا بودن آلفا بیزابولول، دارای خاصیت بهبود زخم می باشد، لذا مطالعه حاضر با هدف بررسی تأثیر کرم بابونه بر بهبود زخم اپی‌زیاتومی انجام شد. روش کار: این مطالعه کارآزمایی بالینی سه سوکور در سال 1392 بر روی 98 زن و...
[ 5 ] - Cuscuta campestris induces apoptosis by increasing reactive oxygen species generation in human leukemic cells
Objective: Cuscuta campestris or common dodder is a holoparasitic plant that has been valorized for treatment of liver injury and cancer prevention in traditional medicine. Recently, extract of C. campestris had shown moderate antimicrobial properties and cytotoxic effects. In this study, we examined the level of cellular oxidants, cytotoxicity, apoptosis and differentiation induced by hydr...
[ 6 ] - Protective effects of long-term administration of Ziziphus jujuba fruit extract on cardiovascular responses in L-NAME hypertensive rats
Objective: Ziziphus jujuba stimulates the release of nitric oxide (NO). Because NO is involved in cardiovascular regulations, in this study the effects of hydroalcoholic extract of Z. jujuba on cardiovascular responses in acute NG-nitro-L-arginine methyl ester (L-NAME) hypertensive rats were evaluated. Materials and Methods: Rats were divided into 6 group (n=6): 1) saline, 2) L-NAME received (...
[ 7 ] - Potentiating effects of Perovskia abrotanoides on pentobarbital-induced sleep
Objective: Sleeplessness is the most common sleep disorder. In this study the hypnotic effect of the hydro-alcoholic extract (HAE) of Perovskia abrotanoides and its water fraction (WF), ethyl acetate fraction (EAF) and n-butanol fraction (NBF) were studied in mice.Materials and Methods: The test compounds were administered intraperitoneally to mice 30 min before the administration of sodium pen...
[ 8 ] - The effect of hydro-alcoholic extract of Achillea millefolium on appetite hormone in rats
Objective: Achillea millefolium (A. millefolium) is known as an orexigenic herb in Iranian traditional medicine. In this study, the possible orexigenic effect of hydro-alcoholic extract of A. millefolium was investigated by measuring plasma ghrelin level.Materials and Methods: Thirty male Wistar rats were divided into five groups. Control group received water. Treatment groups received 50, 100 ...
[ 9 ] - Capparis spinosa reduces Doxorubicin-induced cardio-toxicity in cardiomyoblast cells
Objective: Doxorubicin (DOX) is an effective anticancer drug but its clinical application is limited because it induces apoptosis in cardiomyocytes and leads to permanent degenerative cardiomyopathy and heart failure possibly due to oxidative stress. Recent studies showed that Capparis spinosa (C. spinose)exhibits potent antioxidant activity. So, in this study, we explored the protective effect...
[ 10 ] - Hydroalcoholic extract of needles of Pinus eldarica enhances pentobarbital-induced sleep: possible involvement of GABAergic system
Objective: Insomnia is accompanied by several health complications and the currently used soporific drugs can induce several side effects such as psychomotor impairment, amnesia, and tolerance. The present study was planned to investigate the sleep prolonging effect of Pinus eldarica. Materials and Methods: Hydroalcoholic extract (HAE) of P. eldarica, its water fraction (WF), ethyl acetate frac...
[ 11 ] - Safety evaluation of Phytovagex, a pessary formulation of Nigella sativa, on pregnant rats
Objective: The possible toxicity of drugs in pregnancy should be tested before their use in pregnant patients. In the present study, we aimed to evaluate the safety of phytovagex, a pessary formulation of Nigella sativa (N. sativa), which is already in clinical use for vaginal fungal infection. Materials and Methods: The pregnant rats were treated intravaginal with physiological saline (vehicle...
[ 12 ] - The efficacy of hydro alcoholic extract of Seidlitzia rosmarinus on experimental zoonotic cutaneous leishmaniasis lesions in murine model
Objective: Leishmaniasis is one of the most important parasitic infectious diseases in the world. Since last century, many efforts have been made to control and treat the disease, but appropriate vaccines, pesticides and medicines are not available or even eligible. The purpose of this study was to evaluate the effect of hydro-alcoholic extract of Seidlitzia rosmarinus on the lesions of experim...
[ 13 ] - Antimicrobial activity of aqueous and methanolic extracts of pomegranate fruit skin
Objective: Punica granatum, commonly known as pomegranate, has emerged as a medicinal plant with potential antimicrobial activity. The present study was planned to evaluate this activity against both Gram positive Staphylococcus aureus (S. aureus) and negative Pseudomonas aeruginosa (P. aeruginosa) bacteria as well as against pathogenic yeast, Candida albicans (C. albicans). Material and Metho...
[ 14 ] - Potentiating Effects of Lactuca sativa on Pentobarbital-Induced Sleep
Traditionally, Lactuca sativa (lettuce) has been recommended for its hypnotic property.The present study was planned to investigate sleep-prolonging effect of this plant. The hydroalcoholicextract (HAE) of lettuce and its water fraction (WF), ethyl acetate fraction (EAF),and n-butanol fraction (NBF) were administrated (IP) to mice 30 min before the pentobarbitalinjection. Moreover, both in-vivo...
[ 15 ] - Potentiating Effects of Lactuca sativa on Pentobarbital-Induced Sleep
Traditionally, Lactuca sativa (lettuce) has been recommended for its hypnotic property.The present study was planned to investigate sleep-prolonging effect of this plant. The hydroalcoholicextract (HAE) of lettuce and its water fraction (WF), ethyl acetate fraction (EAF),and n-butanol fraction (NBF) were administrated (IP) to mice 30 min before the pentobarbitalinjection. Moreover, both in-vivo...
[ 16 ] - بررسی اثرات زردچوبه و روغن گاوی بر درمان زخمهای تجربی معده در موش صحرایی
هدف: این مطالعه جهت بررسی اثرات درمانی ترکیب پودر ریزوم زردچوبه و روغن گاوی در درمان زخمهای تجربی معده در موش صحرایی انجام گرفت. مواد و روشها: ایجاد زخم معده در موشهای صحرایی نر تحت 48 ساعت گرسنگی نگهداری شده 250 تا 300 گرمی با استفاده از ایندومتاسین خوراکی (50 میلیگرم بر کیلوگرم حل شده در کربوکسی متیل سلولز 1 درصد) انجام شد. حیوانات بهصورت تصادفی به 5 گروه تقسیم شدند. گروه سالم و غیر ...
[ 17 ] - The impact of Date Palm Pollen Capsule on Vaginal Iubrication and Dyspareunia In Menopausal Woman
Background & aim: Estrogen and androgen deficiency in menopause leads to poor vulvovaginal blood flow, vaginal dryness, and dyspareunia which can reduce the quality of life among the women. In this regard, this study investigated the impact of date palm pollen capsules on vaginal lubrication and dyspareunia in postmenopausal women. Methods: The present triple-blinded, placebo-controlled clinica...
[ 18 ] - Effect of Ocimum basilicum hydro-alcoholic extract on oxidative damage of brain tissue following seizures induced by pentylenetetrazole in mice
Introduction: A relationship between epileptic seizures and brain tissue oxidative damage has been suggested. Ocimum basilicum (O. basilicum) has been shown to have beneficial effects including hypnotic and protective against tissue oxidative damage. The present study was designed to evaluate the effects of O. basilicum hydro-alcoholic extract on oxidative damage of brain tissue following s...
[ 19 ] - اثر عصاره آبی الکلی بارهنگ بر زخم معده ناشی از ایندومتاسین در موش صحرایی
اهداف: گیاه بارهنگ در طب سنتی برای درمان اختلالات گوارشی استفاده می شود، هدف این مطالعه تعیین اثر عصاره آبی الکلی بارهنگ بر زخم معده ناشی از ایندومتاسین بود. مواد و روش ها: در این مطالعه تجربی از 72 سر موش صحرایی نر نژاد ویستار استفاده گردید. در گروههای درمانی، ابتدا با گاواژ ایندومتاسین (mg/kg 35)، زخم معده القا گردید و سپس به مدت 3 روز، به حیوانات، رانیتیدین (mg/kg 50) و دوزهای مختلف عصاره ب...
[ 20 ] - The Effect of nipple soreness treatment with Purslane Cream and Lanolin on Frequency and duration of Breastfeeding in nursing mothers: A Randomized Clinical Trial
Background & aim: Despite the global efforts to promote breastfeeding, women report some problems leading to stop breastfeeding in the early postpartum. Nipple soreness is considered as one of the main causes of early breastfeeding discontinuation. Treatment of this problem could keep breastfeeding for a prolonged period of time. Therefore, the present study aimed to investigate the effect of n...
[ 21 ] - بررسی اثرات ضدّ قارچی عصاره‌های متانولی و آبی برگ و پوست میوه گردو بر روی گونه‌های کاندیدا
Background and Aim: The occurrence of fungal species resistant to antifungal drugs and also their numerous side-effects have persuaded researchers to work on new therapeutic methods. The aim of the present study was to assess anticandidal activities of aqueous and methanol. extracts of walnut fruit, peel, and leaves on different Candida species. Materials and Methods: In the current ...
[ 22 ] - Tanacetum parthenium enhances pentobarbital-induced sleeping behaviors
Objective: Sleep disorders are among the most common psychiatric and medical conditions. In the present study, the hypnotic effect of Tanacetum parthenium was studied in mice. Material and Methods: The hydro-alcoholic extract (HAE) of T. parthenium and three fractions of it, namely water fraction (WF), ethyl acetate fra...
[ 23 ] - The efficacy of camel milk and Tarangabin (manna of Alhagi maurorum( combination therapy on glomerular filtration rate in patients with chronic kidney disease: A randomized controlled trial
Objective: This study was designed to investigate the effect of camel milk and Tarangabin (manna of Alhagi maurorum) combination therapy in addition to conventional treatments in patients with chronic kidney disease (CKD). Material and Methods: Forty-four patients of 15 to 70 years old, with CKD due to hypertension or diabetes, and estimated glomerular filtration rate (eGFR) of 15–60 ml...
[ 24 ] - بررسی تاثیر کپسول سیاه دانه بر کیفیت زندگی دانشجویان دارای سندرم پیش از قاعدگی: کارآزمایی بالینی تصادفی شده
زمینه و هدف: سندرم پیش از قاعدگی مجموعه ای از علائم عاطفی، رفتاری و جسمی است. این سندرم باعث کاهش کیفیت زندگی می شود. کیفیت زندگی یک نتیجه مقیاسی مهم در پزشکی و مراقبت های بهداشتی است. مطالعه حاضر با هدف تعیین تأثیر کپسول سیاه دانه بر کیفیت زندگی دانشجویان دارای سندرم پیش از قاعدگی انجام شد.مواد و روش ها: این مطالعه کارآزمایی بالینی تصادفی دوسوکور در سال 1396 بر روی 84 نفر از دانشجویان دارای ع...
[ 25 ] - Cardiovascular effects of standardized hydroalcoholic extract of Ribes khorasanicum fruit in acute hypertensive rats
Objective: Ribes khorasanicum (R. khorasanicum)traditionally has been used for the treatment of higher blood pressure. In this study, the effect of hydroalcoholic extract of R. khorasanicum fruit in normotensive and hypertensive rats was evaluated. Materials and Methods: Animals were assigned into the following groups: 1) Control, 2) AngII (50 ng/kg), 3) ...
[ 26 ] - The Effects of Recove Ointment on Wound Healing in Mothers Susceptible to Cesarean Section Infection
Background & aim: Due to the development of major complications after cesarean section (C-section), surgical site infection and delayed wound healing was of great concern to gynecologists since a long time ago. It is especially the case for mothers susceptible to post-cesarean wound infection who need special care. The present study therefore aimed to investigate the e...
[ 27 ] - Improving Effect of Ethyl Acetate Fraction of Tanacetum Parthenium Against Brain Oxidative Damage in Pentylenetetrazole-Induced Seizure Model In Mice
Aims: Oxidative stress plays an important role in pathogenesis of seizure. In this study the effect of ethyl acetate fraction of Tanacetum parthenium against brain oxidative damage in pentylenetetrazole-induced (PTZ) seizure model in mice was investigated. Materials and methods: In this experimental study, mice were distributed into 6 groups: 1) Control, 2) PTZ, 3-6) Fraction+PTZ. The animals ...
[ 28 ] - Suppressive Effects of the Aerial Parts of Datura Stramonium L. Extract on Naloxone-Precipitated Morphine Withdrawal Signs in Mice
Background and Objective: Datura stramonium L. is a medicinal herb from the family of Solanaceae. It has been used in herbal remedies for promoting health and treating several diseases. The current study was set up to compare the effects of Datura stramonium L. extract on the naloxone-precipitated opiate-withdrawal in mice. Materials and Methods: Male BALB/c mice (30–35 g, n = 40) were arbitra...
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