بتول حاج ابراهیمی
[ 1 ] - بررسی مروری مولکولهای درگیر در التهاب ایجاد شده در طی افسردگی
زمینه و هدف: افسردگی یکی از مشکلات حال حاضر جوامع پیشرفته و در حال توسعه می‌باشد. مطالعات نشان می دهد که افسردگی نه تنها یک اختلال روانپزشکی بوده، بلکه مشکلات مختلف جسمی را نیز به‌دنبال دارد. از جمله مهمترین مشکلاتی که افسردگی ایجاد می‌کند، اختلالات سیستم ایمنی می‌باشد. مطالعات نشان می‌دهد که افسردگی موجب التهاب مزمن و مخرب توسط سیستم ایمنی می‌شود. به گونه‌ای که التهاب خود موجبات وخیم‌تر شدن اف...
[ 2 ] - TRPV1 receptor-mediated expression of Toll-like receptors 2 and 4 following permanent middle cerebral artery occlusion in rats
Objective(s): Stroke is known as a main cause of mortality and prolonged disability in adults. Both transient receptor potential V1 (TRPV1) channels and toll-like receptors (TLRs) are involved in mediating the inflammatory responses. In the present study, the effects of TRPV1 receptor activation and blockade on stroke outcome and gene expression of TLR2 and TLR4 were assessed following permanen...
[ 3 ] - Significant roles played by interleukin-10 in outcome of pregnancy
Imbalanced immune responses against fetus alloantigens can lead to abnormality in pregnancy. Interleukin-10(IL-10) plays key roles in regulation of immune responses against self and foreign antigens to induce tolerance to these antigens. Therefore, alteration in expression of IL-10 during pregnancy may result in several pathologic conditions such as preterm labor. IL-10 leads to a normal pregna...
[ 4 ] - Opium induces apoptosis in Jurkat cells via promotion of pro-apoptotic and inhibition of anti-apoptotic molecules
Objective(s): The aim of this study was to determine the important molecules involved in apoptosis induction by opium in Jurkat cell line. Materials and Methods: Jurkat cells were incubated 48 hrs with2.86×10-5 g/ml concentration of opium and apoptosis as well as expression levels of related molecules weremeasured. Results: Our results demonstrated that 50.3±0.2 percent of opium treated Jurka...
[ 5 ] - The frequency of CCR5 promoter polymorphisms and CCR5 32 mutation in Iranian populations
Evidence showed that chemokines serve as pro-migratory factors for immune cells. CCL3, CCL4 and CCL5, as the main CC chemokines subfamily members, activate immune cells through binding to CC chemokine receptor 5 or CCR5. Macrophages, NK cells and T lymphocytes express CCR5 and thus, affected CCR5 expression or functions could be associated with altered immune responses. Deletion of 32 base pai...
[ 6 ] - Polymorphisms within Exon 9, But Not Intron 8, of the Vitamin D Receptor Gene Are Associated with Asthma
Objective(s) Deregulation of the immune system through allied factors and cytokine responses are thought to be important contributors to the pathogenesis of asthma. Vitamin D3 and its nuclear receptor appear to be factors that maybe involved in regulating immune responses during the progression of asthma. The aim of this study was to investigate the association between polymorphisms in intron ...
[ 7 ] - MiR-143 Induces Expression of AIM2 and ASC in Jurkat Cell Line
Background: Absent in Melanoma 2 (AIM2) is an intracellular microbial dsDNA sensor which plays an important role in production of proinflammatory cytokines through Apoptosis associated Speck-like protein containing a Caspase activation and recruitment domain (ASC) and Caspase-1. Micro-RNAs (miRNAs) play important roles in regulation of immune related genes. However, there is little information ...
[ 8 ] - Differential Expression of CXCL1, CXCL9 CXCL10 and CXCL12 Chemokines in Alopecia Areata
Background: Alopecia Areata (AA) is a non-scarring, autoimmune disorder which causes hair loss. Inflammatory reactions are involved in hair loss of the scalp and/or body. The involvement of chemokine receptors in the pathogenesis of AA is well defined among which, CXCL1 acts on neutrophils and CXCL9, CXCL10 and CXCL12 and serve as T lymphocytes recruiters. Objective: To study the serum levels o...
[ 9 ] - Expression of CXC Chemokines Gro/KC and SDF-1a in Rat H4 Hepatoma Cells in Response to Different Stimuli
Background: It is now well established that several environmental stress factors cause activation of p38 MAP kinase and JNK in various cell types to produce chemokines. Objective: To investigate the expression of CXC chemokines Gro/KC and SDF- 1a in rat's H4 hepatoma cells in response to heat shock, hyperosmolarity and oxidative stress. Methods: Hepatoma cells were maintained in MEM medium. Cel...
[ 10 ] - Detection of HBV DNA in HBsAg Negative Normal Blood Donors
Background: The risk of infection by transfusion-transmitted viruses has been reduced remarkably. However, a zero-risk blood supply is still desirable. The screening for antibody to HBc (anti-HBc) has been shown as an alternative test for the detection of HBV infection. Objective: The main aim of this study was to evaluate HBV infection markers and the potential value of anti-HBc testing of blo...
[ 11 ] - The effect of depression and anxiety on expression levels of toll like receptor signaling moleculesin chronic HBV infected patients
Background: Toll- like receptors (TLRs) play an important role in the recognition of DAMPs and PAMPs and induction ofinflammation. Previous studies demonstrated that depression and anxiety can influence the expression levels of immune related molecules. Our previous study revealed that mRNA levels of IRAK4, TRAF3 and IRF7 were significantly decreased in chronic HBV infected (CHB) patients whe...
[ 12 ] - A study of the status of the elderly; bacterial infections, their causes, prevention, and control methods
Background: On the 26th anniversary of the International Day of Older Persons in 2015 with the slogan "the elderly, advocates of dynamism, growth, and the youth of the population", 12% (900 million individuals) of the world population were above 65 years of age. It is estimated that this rate will reach 22% (2 milliard individuals) by 2050. The purpose of the present study was to dete...
[ 13 ] - IL-8 May Be the Target of Arsenic in Human Breast Milk
Background and Aims: The critical aim of this study was to evaluate the effects of breast-milk contamination with Nickel and Arsenic, as well as aflatoxin M1 (AFM1) on the milk levels of IL-6 and IL-8. Materials and Methods: Breast milk was collected from 76 mothers on the 30th day post-parturition and milk levels of AFM1, Nickel, Arsenic, IL-6 and IL-8 were evaluated. Results: The results s...