محمدابراهیم رضوانی
دانشیار فیزیولوژی، مرکز تحقیقات گیاهان دارویی، دانشگاه علوم پزشکی شهید صدوقی، یزد
[ 1 ] - اثر سالویجنین، فلاونوئید استخراج شده ازگیاه مریم گلی، بر برخی شاخص های دیابتی و کمیت های قلبی درموش صحرایی دیابتی نوع 1
زمینه و هدف:بخشی از اثر ضد دیابتی گیاهان داروئی به فلاوونوئید های موجود در آنها مرتبط است. از آنجاییکه فلاوونوئید های متفاوتی در گیاهان دیده شده است، اثر سالویجنین که یک فلاوونوئید موجود در این گیاه است را مورد بررسی قرار دادیم. مواد و روش ها:پس از عصاره گیری از گیاه با روش کروماتوگرافی ستونی سالویجنین استخراج گردید. با تزریق استرپتوزوتوسین (mg/kg70)، موش های صحرایی دیابتی شدند. حیوانات گروه کن...
[ 2 ] - The effect of asafoetida essential oil on myocardial ischemic-reperfusion injury in isolated rat hearts
Objective: Previous studies reported that asafetida from Ferula assa-foetida Linn. species and its essential oil (AEO) have antioxidant effects. In the present study, the effect of AEO was evaluated on ischemic-reperfusion injury in isolated rat hearts. Materials and Methods: Forty-eight male Wistar rats were divided into 6 groups: 1) control group, 2) vehicle group, 3-5) AEO groups and, 6) car...
[ 3 ] - The effect of Zataria multiflora Boiss hydroalcoholic extract and fractions in pentylenetetrazole-induced kindling in mice
Objective: At present, there are many antiepileptic drugs with a wide range of side effects on the human body. It was assumed that Zataria multiflora Boiss (Z. multiflora) with sedative, anti-spasmodic and anti-inflammatory activity may be effective in the treatment of epilepsy. The aim of the present study was to elucidate the effect of Z. multiflora hydroalcoholic extract and its fraction ext...
[ 4 ] - Neuroprotective effect of berberine chloride on cognitive impairment and hippocampal damage in experimental model of vascular dementia
Objective(s):The major objective of the present study was to investigate the potential neuroprotective effect of berberine chloride on vascular dementia. Berberine, as an ancient medicine in China and India, is the main active component derived from the Berberis sp. Several studies have revealed the beneficial effects of berberine in various neurodegenerative disorders. Materials and Methods: T...
[ 5 ] - Prolonged Oral Administration of Oleuropein Might Protect Heart against Aconitine-induced Arrhythmia
In this study, it was surveyed to know whether an oral single dose of oleuropein could mimic the cardiac preconditioning in rats’ hearts or whether its prolonged oral administration could protect the heart against the aconitine-induced arrhythmia in rats. Eighty male Wistar rats were divided into two series (n = 8 in each group). In the first series, all groups (except the control (Con) group) ...
[ 6 ] - Prolonged Oral Administration of Oleuropein Might Protect Heart against Aconitine-induced Arrhythmia
In this study, it was surveyed to know whether an oral single dose of oleuropein could mimic the cardiac preconditioning in rats’ hearts or whether its prolonged oral administration could protect the heart against the aconitine-induced arrhythmia in rats. Eighty male Wistar rats were divided into two series (n = 8 in each group). In the first series, all groups (except the control (Con) group) ...
[ 7 ] - مقایسه اثر ضد درد صمغ کتیرا با مورفین و دیکلو فناک در موش سفیدکوچک آزمایشگاهی با استفاده از آزمونهای قدکشیدن و صفحه داغ
Background and Objective: Some of medicinal plants have been used for pain reliving in Iarnian ancient medicine. Astragalus gummifer (AG) is one of them and its gum (tragacanth gum) were used for several health purposes. The present study was conducted to evaluate the analgesic effects of this gum in mice. Materials and Methods: In this study, the analgesic effect of tragacanth gum was...
[ 8 ] - اثر سالویجنین بر یادگیری و حافظه و میزان بیان ژن mRNA فاکتور رشد دهنده عصبی مشتق از مغز (BDNF ) در هیپوکمپ موش صحرایی نر آلزایمری شده
Introduction: Effects of many flavonoids have been studied on memory, learning and improvement of Alzheimer. Many flavonoids are effective in the improvement of Alzheimer. Since no study has been conducted on the effect of salvigenin on memory and learning, our aim was to examine the effect of this flavonoid. Methods: Intraperitoneal injection of D-galactose at a dose of 120 mg / kg was used f...
[ 9 ] - بررسی اثرات عصاره آبی میوه شاه‌توتMorus Nigra بر ترمیم زخم در موش‌های دیابتی نوع 1
Introduction: Delay in wound healing is one of several complications of type 1 diabetes. It has been reported that the use of various herbal extracts such as Morus nigra increase the wound healing. Since,there are no studies on investigation of the effects of Morus nigra on wound healing in diabetics so this study was conducted to determine wound healing effects of Morus nigra in di...
[ 10 ] - اثر عصاره آبی شیرین بیان و ویتامین C بر اختلالات حرکتی ناشی از آکریل آمید در موش صحرایی
Introduction: Acrylamide is a chemical compound which can be produced while frying carbohydrates in high- temperatures. Since the neurotoxicity of acrylamide was reported in the previous studies, the aim of the present study was to investigate the effects of co-administration of Glycyrrhiza Glabra and Vitamin C on acrylamide-induced weight loss and motor deficits in rats. Methods: In this exp...
[ 11 ] - بررسی اثر هیپوترمی جنرال بر سکته مغزی مدل آمبولیک در موش صحرایی نر
Introduction: Hypothermia has neuroprotective effects in permanent or transient models of cerebral artery occlusion. In the current study, neuroprotective effect of general hypothermia in the embolic model of stroke, in which no study has been conducted to date. Methods: In this experimental study, twenty-four male Wistar rats (250 to 350 g) were divided into three groups as following: sha...
[ 12 ] - بررسی اثر مصرف خوراکی آنغوزه اشکی بر پارامترهای بیوشیمیایی کبدی، کلیوی، قلبی و خونی رت
Introduction: Today it has been documented that herbal medicines like synthetic drugs have side effects. The aim of his study was that whether assafoetida in doses used in most of previous studies have any effect on hepatic, renal, cardiac and blood biochemical parameters of rats. Methods: Forty male Wistar rats, with average weighting of 300 grams, were divided into five groups of eight in ea...
[ 13 ] - اثر تزریق داخل بطنی سالوبرینال، یک مهار کننده جدید سنتز پروتئین، بر تشنجات ناشی از پنتیلن تترازول در موش صحرایی نر
Background and Objective: Salubrinal- a protein synthesis inhibitor- plays a crucial role in sleep and neuronal inhibition through the GABA activation. According to these evidences, the aim of the present study was to determine the effect of salubrinal on epileptic seizures induced by pentylenetetrazol (PTZ). Materials and Methods: In this expremental study under stereotaxical surgery,...
[ 14 ] - Effects of Hydrogen Peroxide Oxidative Stress on the Pattern of Pro-apoptotic and Anti-apoptotic Genes Expression During PC12 Cells Differentiation
Background and Aims:In neurodegenerative disorders,oxidative stress mediated by reactive oxygen species is strongly associated with increased neuronal damages which can lead to apoptosis. Pro-apoptotic and anti-apoptotic gene expressions are changed during the cell differentiation that affect cell viability and differentiation. Therefore, this study was conducted to determine the effects of hyd...
[ 15 ] - مقایسه اثرات ضدّ دردی عصاره هیدروالکلی گیاه پونه (Mentha longifolia) با مرفین در موش سوری نر
Background and Aim: Long-term consumption of many drugs followed by reduction of their effectiveness has necessitated performing research on new analgesics .Thus, the present study was conducted to evaluate the analgesic effects of mentha longifolia and morphine in mice using writhing and hot plate tests. Materials and Methods: In this experimental study, 70 male rats were divided into 7 equal ...
[ 16 ] - Study and Comparison of Genetically and Non-Genetically Modified Rice from View Point of Possibility of Gene Transferring in Blood of Labouraty Animal
Introduction: Genetically modified plants species of plants are produced by the genetic engineering of agricultural science and the addition of specific genes in their genetic sequences with the aim of optimizing the product and creating desirable traits. This study examined the remains of Cry1A(b) and P35 genes in blood of rats fed with genetically modified rice. Methods: This study was exper...
[ 17 ] - Effect of Myricetin on the Prevention of Noise-Induced Hearing Loss-An Animal Model
Introduction: Exposure to hazardous noise induces one of the forms of acquired and preventable hearing loss that is noise-induced hearing loss (NIHL). Considering oxidative stress as the main mechanism of NIHL, it is possible that myricetin can protect NIHL by its antioxidant effect. Therefore, the present study aimed to investigate the preventive effect of myricetin on NIHL. <br /...
[ 18 ] - Effect of myricetin on the gene expressions of NOX3, TGF-β1, prestin, and HSP-70 and anti-oxidant activity in the cochlea of noise-exposed rats
Objective(s): Noise-induced hearing loss is one of the most common occupational diseases in industrialized countries and can be affected by various environmental and genetic factors. This study was designed to examine the effect of myricetin in preventing this disorder.Materials and Methods: Twenty-one Wistar rats were randomly divided i...
[ 19 ] - Effects of Chlorogenic Acid on Epileptic Behavior and mRNA Expressions of Brain Derived Neurotrophic Factor in the Brain of Aged Rats
Introduction: The present study was conducted to evaluate the effect of Chlorogenic Acid (CA) and Diazepam (DZP) on epileptic complication that induced by repetitive intra-peritoneal injections of Pentylenetetrazle (PTZ) in aged rats. Methods: Twenty-four month-old male Wistar rats (age > 12 months, 300-350 g) were divided in 4 experimental groups. Animal in control group (PTZ + Vehicle) re...
[ 20 ] - Lack of effect of plasma of myocardial preconditioned, ischemic and ischemic-reperfused rats of myocardium on differentiation of mesenchymal stem cells into cardiomyocytes
Introduction: Numerous studies have shown that enriched plasma protects myocardial cells against ischemia. The aim of this study was to evaluate the effect of rat enriched plasma by preconditioning, ischemia, and reperfusion on the differentiation of bone marrow mesenchymal stem cells (BMMSC) into cardiomyocytes. Methods: In this experimental and laboratory study, BMMSCs were extracted from th...
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