بی بی صدیقه فضلی بزاز
استاد گروه شیمی دارویی، دانشکده داروسازی، عضو مرکز تحقیقات علوم داروئی و مرکز تحقیقات بیوتکنولوژی داروئی دانشگاه علوم پزشکی مشهد، ایران
[ 1 ] - بررسی اثر ضد میکروبی عصاره آبی و الکلی کلاله زعفران بر روی میکروب های پاتوژن دهان (استرپتوکوک موتانس، لاکتوباسیل،کاندیدا آلبیکنس)
مقدمه: پوسیدگی دندانی یک بیماری عفونی است که میکروارگانیسم های مختلفی در ایجاد و پیشرفت آن نقش دارند. داروهایی که برای کاهش میکروب ها مورد استفاده قرار می گیرند دارای عوارض جانبی می باشند. بنابراین جستجو برای مواد ضدمیکروبی که حداقل عوارض جانبی را داشته باشند، ضروری است. لذا هدف از این مطالعه بررسی اثر ضدمیکروبی عصاره آبی و الکلی زعفران بر میکروب های بیماری زا حفره دهان می باشد. مواد و روش ها: ...
[ 2 ] - بررسی ویژگی های فیزیکوشیمیایی و میکروبی ماست های سنتی عشایر خراسان رضوی
ماست یکی از معروفترین فرآورده‌های لبنی تخمیری در دنیا بخصوص خاورمیانه می‌باشد. به هر حال محصولات سنتی همچون فرآورده‌های لبنی تولید شده توسط عشایر به دلیل شرایط بهداشتی ضعیف هنگام دوشش و نگهداری، تیمار حرارتی نامناسب و آلودگی ثانویه، می‌تواند محیط مناسبی برای رشد و تکثیر و همچنین انتقال دامنه وسیعی از عوامل میکروبی بیماریزا باشد. هدف این مطالعه بررسی ماست سنتی عشایر از جنبه خصوصیات بهداشتی و شیم...
[ 3 ] - In vitro evaluation of antibacterial activity of verbascoside, lemon verbena extract and caffeine in combination with gentamicin against drug-resistant Staphylococcus aureus and Escherichia coli clinical isolates
Objective: In recent years, there has been an increasing interest in using herbal products to overcome bacterial resistance. The aim of this study was to investigate the effect of lemon verbena aqueous extract, verbascoside and caffeine in combination with gentamicin against standard and clinical isolates of Staphylococcus aureus and Escherichia coli strains. Materials and Methods: The MIC and ...
[ 4 ] - The osteogenesis of bacterial cellulose scaffold loaded with fisetin
Objective(s): Bacterial cellulose (BC) has applications in medical science, it is easily synthesized, economic and purer compared to plant cellulose. The present study aimed to evaluate BC, a biocompatible natural polymer, as a scaffold for the bone marrow mesenchymal stem cells (BMSCs) loaded with fisetin, a phytoestrogen.Materials and Methods: BC hydrogel scaffold was prepared from Gluconacet...
[ 5 ] - Iranian Journal of Basic Medical Sciences comes of age on the 20th anniversary of publication
[ 6 ] - Characterization of Encapsulated Berberine in Yeast Cells of Saccharomyces cerevisiae
Berberine was loaded in yeast cells of Saccharomyces cerevisiaeas a novel pharmaceutical carrier to improve the treatment ofmany diseases. The yeast-encapsulated active materialsshowedhigh stability and bioavailability due to the enhanced solubility and sustained releasing. In this study, different characteristics of prepared berberine loaded yeast cells (loading capacity, release kinetic order...
[ 7 ] - UV Spectrophotometric Determination and Validation of Hydroquinone in Liposome
The method has been developed and validated for the determination of hydroquinone in liposomal formulation. The samples were dissolved in methanol and evaluated in 293 nm. The validation parameters such as linearity, accuracy, precision, specificity, limit of detection (LOD) and limit of quantitation (LOQ) were determined. The calibration curve was linear in 1-50 µg /mL range of hydroquinone an...
[ 8 ] - Standardizing the Bactericidal Activities of Silver Nanoparticles Made By Electrochemical Reduction and Comparing It with Deconex 53 Instrument
Silver nanoparticles have proved to possess significant antibacterial properties. Nanosilver produced by electrochemical reduction stabilized by cellulose derivatives, has been evaluated by European standards (CEN TC 216) in order to find out whether they could be applied in food, industrial, domestic and institutional areas as a suitable disinfectant. Moreover, bactericidal activity of nanosil...
[ 9 ] - Characterization of Encapsulated Berberine in Yeast Cells of Saccharomyces cerevisiae
Berberine was loaded in yeast cells of Saccharomyces cerevisiaeas a novel pharmaceutical carrier to improve the treatment ofmany diseases. The yeast-encapsulated active materialsshowedhigh stability and bioavailability due to the enhanced solubility and sustained releasing. In this study, different characteristics of prepared berberine loaded yeast cells (loading capacity, release kinetic order...
[ 10 ] - UV Spectrophotometric Determination and Validation of Hydroquinone in Liposome
The method has been developed and validated for the determination of hydroquinone in liposomal formulation. The samples were dissolved in methanol and evaluated in 293 nm. The validation parameters such as linearity, accuracy, precision, specificity, limit of detection (LOD) and limit of quantitation (LOQ) were determined. The calibration curve was linear in 1-50 µg /mL range of hydroquinone an...
[ 11 ] - Standardizing the Bactericidal Activities of Silver Nanoparticles Made By Electrochemical Reduction and Comparing It with Deconex 53 Instrument
Silver nanoparticles have proved to possess significant antibacterial properties. Nanosilver produced by electrochemical reduction stabilized by cellulose derivatives, has been evaluated by European standards (CEN TC 216) in order to find out whether they could be applied in food, industrial, domestic and institutional areas as a suitable disinfectant. Moreover, bactericidal activity of nanosil...
[ 13 ] - Does Biosynthetic Silver Nanoparticles Are More Stable With Lower Toxicity than Their Synthetic Counterparts?
Control of size and shape is a challenge in nanoparticle synthesis. Synthetic and biosynthetic (both extracellular and intracellular) methods are used to prepare silver nanoparticle (SNP). In this study, the behavior of three strains of Staphylococcus aureus (S. aureus) was investigated in the presence of silver nitrate intra- and extracellularly. S. aureus strains biosynthesized SNPs intracell...
[ 14 ] - Does Biosynthetic Silver Nanoparticles Are More Stable With Lower Toxicity than Their Synthetic Counterparts?
Control of size and shape is a challenge in nanoparticle synthesis. Synthetic and biosynthetic (both extracellular and intracellular) methods are used to prepare silver nanoparticle (SNP). In this study, the behavior of three strains of Staphylococcus aureus (S. aureus) was investigated in the presence of silver nitrate intra- and extracellularly. S. aureus strains biosynthesized SNPs intracell...
[ 15 ] - طراحی و ساخت حامل لنتی ویروسی بیان کننده miRNA-499a و انتقال آن به سلول های بنیادی مزانشیمی انسان
Background and purpose: Lentiviral vectors (LVs) are suitable candidates for gene delivery to cells with stable and high-level of transgene expression in target cells. MicroRNAs (miRNAs, miRs) are non-protein coding, short (~22 nucleotides) and single-stranded RNAs that act as post-transcriptional regulators of gene expression, and are involved in various cellular processes, including prolifera...
[ 16 ] - بررسی ویژگی های فیزیکوشیمیایی و میکروبی ماست های سنتی عشایر خراسان رضوی
ماست یکی از معروفترین فرآورده‌های لبنی تخمیری در دنیا بخصوص خاورمیانه می‌باشد. به هر حال محصولات سنتی همچون فرآورده‌های لبنی تولید شده توسط عشایر به دلیل شرایط بهداشتی ضعیف هنگام دوشش و نگهداری، تیمار حرارتی نامناسب و آلودگی ثانویه، می‌تواند محیط مناسبی برای رشد و تکثیر و همچنین انتقال دامنه وسیعی از عوامل میکروبی بیماریزا باشد. هدف این مطالعه بررسی ماست سنتی عشایر از جنبه خصوصیات بهداشتی و شیم...
[ 17 ] - Chemical composition and antibacterial properties of Peganum harmala L.
Objective: The present study was conducted to investigate antibacterial properties of fruit and flower of Peganum harmala. Material and Methods: Column chromatography, followed by preparative thin layer chromatography (TLC) was used for final purification. The structure of pure alkaloids was determined using spectroscopic methods (1H-N...
[ 19 ] - Encapsulation of Zataria multiflora Essential Oil in Saccharomyces cerevisiae: Sensory Evaluation and Antibacterial Activity in Commercial Soup
Nowadays rising consumer concern on the safety of synthetic chemical food preservatives is a reason for finding natural new antimicrobial agents, especially among the components of medicinal plants such as Essential Oils (EOs). However, most EOs are sensitive to oxygen, light, and temperature and can be easily degraded. Some EOs have strong taste, flavor, and affect the organoleptic charact...
[ 20 ] - Topical green tea formulation with anti-hemorrhagic and antibacterial effects
Objective(s): Potentially preventable death from uncontrolled hemorrhage clearly indicates the importance of simple, fast and efficient ways to achieving hemostasis. The aim of this study was to develop a topical formulation of green tea extract for reducing bleeding that can be helpful in hemorrhage control.Materials and Methods: Hydroa...
[ 21 ] - Fabrication and Structural, Mechanical, and Biological Characterization of Vancomycin-Loaded Chitosan-Hydroxyapatite-Gelatin Beads for Local Treatment of Osteomyelitis
Background and purpose: Topical antibiotic medication is an alternative method in treatment of local infections, especially osteomyelitis. Currently several biomaterials are used for this purpose. The present study focused on the fabrication and characterization of chitosan and Vancomycin (VCM)-loaded chitosan (CS)-hydroxyapatite (HA)-gelatin (G) bead in treatment of osteomyelitis. Materials ...
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