جواد آخوندیان
استاد گـروه بیماریهـای کودکـان، دانـشگاه علوم پزشکی مشهد، مشهد، ایران
[ 1 ] - ایجاد تسکین طی آندوسکوپی دستگاه گوارش در کودکان مقایسه دو روش
مقدمه آندوسکوپی یک روش تهاجمی و دردناک در کودکان است. کودکان نمی توانند اضطراب و استرس را تحمل کنند، لذا برای آندوسکوپی نیاز به استفاده از روش های کاهش اضطراب و استرس می باشد. هدف این مطالعه مقایسه پروپوفل در مقابل میدازولامداخل وریدی جهت کاهش اضطراب در کودکان است. روش کار این مطالعه به صورت کار آزمایی بالینی تصادفی، بر 103 بیمار (14-2 سال) در مدت 9 ماه در سال 1385 در بیمارستان قائم (عج) مشهد ا...
[ 2 ] - توپیرامات در درمان صرع مقاوم کودکان
مقدمه: 0/5 تا 1% کودکان مبتلا به صرع هستند و 20% آنها نسبت به درمان مقاومند. توپیرامات یک داروی ضد صرع قوی است که به عنوان تک دارو یا همراه با سایر داروهای ضد صرع برای درمان انواع مختلفی از صرع مورد استفاده قرار می گیرد؛ا ما مطالعه ی چاپ شده ای در باره ی اثر آن در کودکان ایرانی توسط نویسندگان این مقاله یافت نشد. به همین علت این مطالعه با هدف بررسی اثر توبیرات در کودکان دارای صرع مقاوم به درمان ...
[ 3 ] - Neonatal Infections: a 5-Year Analysis in a Neonatal Care Unit in North East of Iran
Background: Neonatal infections are one of the major causes of death in Iran. Since identifying the risk factors, types, site, bacterial causes, and case fatality rate of an infection can be effective in selecting preventive and therapeutic methods, and appropriate supportive measures, this study aimed to investigate the aforementioned factors in the neonatal intensive care unit (NICU) of Ghaem...
[ 4 ] - The Effect of Melatonin on Pediatric Drug-Resistant Epilepsy; a Randomized Double Blind Clinical Trial
BackgroundAbout 15 to 40% of children with seizures are refractory to standard anti-epileptic drugs and for such patients, other treatments such as surgery and the ketogenic diet can reduce seizure frequency. Melatonin is a natural pineal gland hormone. The use of melatonin for controlling pediatric seizures is still controversial. This study aimed to evaluate the effect of melatonin on seizure...
[ 5 ] - Evaluation of Liver Enzymes Rising in Patients Treated with Sodium Valproate (VPA)
Introduction Valproic acid (VPA, Valproate) is an eight-branch fatty acid and varies from other antiepileptic drugs. VPA use might lead to mild to severe hepatotoxicity. The aim of this study was to investigate valproic acid impact on liver transaminases at the beginning of VPA treatment and after three and six months of it. Materials and Methods This study was designed as a cross sectional pro...
[ 6 ] - Spinal Muscular Atrophy: A Short Review Article
Spinal muscular atrophy (SMA) is a genetic disorder which affect nervous system and is characterized with progressive distal motor neuron weakness. The survival motor neuron (SMN) protein level reduces in patients with SMA. Two different genes code survival motor neuron protein in human genome. Skeletal and intercostal muscles denervation lead to weakness, hypotony, hyporeflexia, respiratory fa...
[ 7 ] - A Treatable Refractory Epilepsy: A Case Report
Introduction Biotinidase deficiency is a life threatening inborn error of metabolism specially when delayed in diagnosis. We report a 2-month-old male infant that presented with refractory infantile spasm, alopecia and seborrheic dermatitis. With a high suspicion of the biotinidase deficiency we started biotin 10 mg daily orally before definite diagnosis was made. Rapid treatment was life-savin...
[ 8 ] - Acute Flaccid Myelitis in A 9- year- old Girl: A Case Report
Acute Flaccid Myelitis (AFM), a polio-like paralysis in children no older than 21, has recently reemerged and increasing numbers of such cases have been reported worldwide since 2012. Accurate and early diagnosis of this condition could help with better management of the disease. A 9- year- old girl with chief complaint of headache, fever and vomiting was subsequently affected by an acute...
[ 9 ] - A Single-center Randomized Clinical Trial Comparing the Treatment Efficacy of High Dose Oral Prednisolone with Intramuscular Adrenocorticotropic Hormone in Patients with Infantile Spasm
Background Infantile spasm is a rare condition in infants from 4 to 7 months old. Treatment varies in different cases. Corticosteroids and adrenocorticotropic hormone (ACTH) are the most widely used treatment options; however, there are debates on their efficacy. The aim of our study is to compare corticosteroid treatment with ACTH in patients with infantile spasm. Materials and Me...
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