رویا صادق نیا

[ 1 ] - بررسی اثر پیوند اتولوگ سلول‌های بنیادی مغز استخوان بر پانل رِاکتیو آنتی بادی در بیماران با نارسایی مزمن و پیشرفته کلیه کارآزمایی بالینی آزمایشی

مقدمه در سالهای اخیر توجه ویژهای به نقش تعدیل کننده سیستم ایمنی سلولهای بنیادی شده است. هدف این مطالعه بررسی اثر پیوند اتولوگ سلولهای بنیادی مغز استخوان بر پانل راکتیو آنتی بادی در بیماران با نارسایی مزمن و پیشرفته کلیه است. روش کار مطالعه حاضر بهصورت پایلوت بر 17 بیمار که در دو گروه مداخله 9 نفره و گروه شاهد 8 نفره تقسیمبندی شدند صورت پذیرفت. پانل راکتیو آنتی بادی قبل از مطالعه و پس ...

[ 2 ] - The role of local renin-angiotensin system on high glucose-induced cell toxicity, apoptosis and reactive oxygen species production in PC12 cells

Objective(s): Hyperglycemia, oxidative stress and apoptosis have key roles in pathogenesis of diabetic neuropathy. There are local renin-angiotensin systems (RASs) in different tissues such as neural tissue. Local RASs are involved in physiological and pathophysiological processes such as inflammation, proliferation and apoptosis. This study aimed to investigate the role of local renin-angioten...

[ 3 ] - Review of the Pharmacological and Toxicological Effects of Salvia leriifolia

Salvia leriifolia Benth. (vernacular names such as Nuruozak and Jobleh) is a perennial herbaceous plant that grows exclusively in south and tropical regions of Khorasan and Semnan provinces, I. R. Iran. Unlike other species of Salvia genus, the chemical constituents of S. leriifolia are not well recognized. The stem oil of the plant consisted mainly both monoterpenes and sesquiterpenes, while i...

[ 4 ] - The Effects of Nigella Sativa Hydro-alcoholic Extract on Memory and Brain Tissues Oxidative Damage after Repeated Seizures in Rats

Regarding the therapeutic properties of Nigella sativa (NS), the effects of the plant hydro – alcoholic extract on learning, memory and brain tissues oxidative damage were investigated in penthylenetetrazole (PTZ) - induced repeated seizures.There were 4 experimental groups including: 1- control group; received saline, 2- PTZ group ; received saline and PTZ (50 mg/kg, i.p) , 3-PTZ- NS 200 and 4...

[ 5 ] - Effect of Zirconium Dioxide Nanoparticles on Glutathione Peroxidase Enzyme in PC12 and N2a Cell Lines

Objective: Today, special attention is paid to the use of zirconium dioxide nanoparticle (nano-ZrO2), a neutral bioceramic metal, particularly for drug and gene delivery in medicine. However, there are some reports implying that use of nano-ZrO2 is associated with cytotoxic effects like inhibiting the cell proliferation, DNA damage and apoptosis. In the present study, we examined whether nano-Z...

[ 6 ] - Potentiating Effects of Lactuca sativa on Pentobarbital-Induced Sleep

Traditionally, Lactuca sativa (lettuce) has been recommended for its hypnotic property.The present study was planned to investigate sleep-prolonging effect of this plant. The hydroalcoholicextract (HAE) of lettuce and its water fraction (WF), ethyl acetate fraction (EAF),and n-butanol fraction (NBF) were administrated (IP) to mice 30 min before the pentobarbitalinjection. Moreover, both in-vivo...

[ 7 ] - The Effects of Nigella Sativa Hydro-alcoholic Extract on Memory and Brain Tissues Oxidative Damage after Repeated Seizures in Rats

Regarding the therapeutic properties of Nigella sativa (NS), the effects of the plant hydro – alcoholic extract on learning, memory and brain tissues oxidative damage were investigated in penthylenetetrazole (PTZ) - induced repeated seizures.There were 4 experimental groups including: 1- control group; received saline, 2- PTZ group ; received saline and PTZ (50 mg/kg, i.p) , 3-PTZ- NS 200 and 4...

[ 8 ] - Effect of Zirconium Dioxide Nanoparticles on Glutathione Peroxidase Enzyme in PC12 and N2a Cell Lines

Objective: Today, special attention is paid to the use of zirconium dioxide nanoparticle (nano-ZrO2), a neutral bioceramic metal, particularly for drug and gene delivery in medicine. However, there are some reports implying that use of nano-ZrO2 is associated with cytotoxic effects like inhibiting the cell proliferation, DNA damage and apoptosis. In the present study, we examined whether nano-Z...

[ 9 ] - Potentiating Effects of Lactuca sativa on Pentobarbital-Induced Sleep

Traditionally, Lactuca sativa (lettuce) has been recommended for its hypnotic property.The present study was planned to investigate sleep-prolonging effect of this plant. The hydroalcoholicextract (HAE) of lettuce and its water fraction (WF), ethyl acetate fraction (EAF),and n-butanol fraction (NBF) were administrated (IP) to mice 30 min before the pentobarbitalinjection. Moreover, both in-vivo...

[ 10 ] - Effect of Ocimum basilicum hydro-alcoholic extract on oxidative damage of brain tissue following seizures induced by pentylenetetrazole in mice

Introduction: A relationship between epileptic seizures and brain tissue oxidative damage has been suggested. Ocimum basilicum (O. basilicum) has been shown to have beneficial effects including hypnotic and protective against tissue oxidative damage. The present study was designed to evaluate the effects of O. basilicum hydro-alcoholic extract on oxidative damage of brain tissue following s...

[ 11 ] - Anticonvulsant Activity of Viola tricolor against Seizures Induced by Pentylenetetrazol and Maximal Electroshock in Mice

Background: Recently, there has been much more interest in the use of medicinal plants in search of novel therapies for human neurodegenerative diseases such as epilepsy. In the present study, we investigated the anticonvulsant effects of Viola tricolor (V. tricolor) on seizure models induced by pentylenetetrazol (PTZ) and maximal electroshock stimulation (MES). Methods: Totally, 260 mice were ...

[ 12 ] - Effect of rutin on oxidative DNA damage in PC12 neurons cultured in nutrients deprivation condition

Objective(s): Rutin is a flavonoid with potent antioxidant property, which exhibited cytoprotective effects in several models of neuronal injury. This work aimed to examine whether rutin can protect neurons against oxidative DNA damage caused by serum/glucose deprivation (SGD) as an in vitro model of neurodegeneration and ischemia. Materials and Metho...

[ 13 ] - Assessment of phytochemical components and antioxidant activity of Rheum turkestanicum Janisch

Background & Aims: Plants contain high antioxidant activities due to their redox and the chemical properties are affluent in secondary metabolites such as phenols, flavonoids, and other components. Rheum turkestanicum Janisch is a plant from polygonaceae that is widely used for diabetes. At this project that is a part of national thesis, relative levels of antioxidant activity, total phenols, t...

[ 14 ] - Potential protective roles of phytochemicals on glutamate-induced neurotoxicity: A review

Glutamate, as an essential neurotransmitter, has been thought to have different roles in the central nervous system (CNS), including nerve regeneration, synaptogenesis, and neurogenesis. Excessive glutamate causes an up-regulation of the multiple signaling pathways, including phosphoinositide-3 kinase/protein kinase B (PI3K/Akt), Akt/mammalian target of rapamycin (mTOR) protein, mitogen-activat...

[ 15 ] - The Effect of Diazinon on Cell Proliferation and Apoptosis in Testicular Tissue of Rats and The Protective Effect of Vitamin E

Objective Diazinon is an organophosphate pesticide and today this pesticide is mostly used in agriculture. In this study, we analyzed the effects of diazinon and vitamin E on apoptosis and the proliferation of germ cells in rat testis. MaterialsAndMethods In this experimental study 30 male wistar rats, were divided into five groups (N=6). Control, sham (received olive oil), experimental group 1...