مریم شیخی
کارشناس ارشد ژنتیک،دانشگاه علوم پزشکی مشهد،مشهد،ایران
[ 1 ] - مروری بر مقاومت آنتی بیوتیکی هلیکوباکتر پیلوری در ایران و جهان
مقدمه هلیکوباکتر پیلوری تقریبا 50% افراد را در سرتاسر دنیا آلوده کرده است. میزان بروز سالانه ی عفونت هلیکوباکتر پیلوری در کشورهای در حال توسعه و توسعه یافته به ترتیب 15-4% و 5/0%میباشد که میزان قابل توجهی محسوب می شود. هدف از این مطالعه، مروری بر مقاومت آنتی بیوتیکی در ایران و سایر نقاط جهان میباشد. روش کار با استفاده از پایگاههای اطلاعاتی Scopus, Pubmed، (SID),ISI , ،Embase وGoogle scho...
[ 2 ] - Lack of FLT3-TKD835 gene mutation in toxicity of sulfur mustard in Iranian veterans
Objective(s):Sulfur mustard (SM) was used by the Iraqi army against the Iranian troops in the Iran-Iraq war from 1983–1988. This chemical gas affects different organs including the skin, lungs and the hematopoietic system. Any exposure to SM increases the risk of chromosomal breaking, hyperdiploidy and hypodiploidy. Studies have shown that the risk for acute myeloblastic and lymphoblastic leuke...
[ 3 ] - Chromogenic in situ Hybridization Compared with Real Time Quantitative Polymerase Chain Reaction to Evaluate HER2/neu Status in Breast Cancer
Background and objective: The assessment of human epidermal growth factor receptor 2 (HER2) status has become of great importance in the diagnosis of breast cancer. The aim of this study was to investigate the diagnostic value of quantitative Polymerase Chain Reaction (qPCR) and Chromogenic In Situ Hybridization (CISH) to assess HER2 status of biopsy specimens. <...
[ 4 ] - Fluorescent in Situ Hybridization and Real-Time Quantitative Polymerase Chain Reaction to Evaluate HER-2/neu Status in Breast Cancer
Background:Breast cancer remains the most common and second lethal cancer in females. HER-2/neu is one of the most important amplified oncogene in breast cancer. The amplification of HER-2 is correlated with decreased survival, metastasis, and early recurrence. The amplification of HER-2/neu gene and synthesis of th...
[ 5 ] - Relationship Between SOX17 Gene Expression and Prognosis in Acute Myeloid Leukemia
Background: Acute Myeloid Leukemia (AML) is a group of heterogeneous malignancies caused by defects in differentiation of hematopoietic cells. SRY-box containing gene 17(SOX17) is a transcription factor which plays an important role in several biological processes, including cardiogenesis, angiogenesis, and lymphopoiesis. Aberrant expression of SOX17 has been detected in solid tumors. This stud...
[ 6 ] - Analysis of KRAS gene mutation associated with Helicobacter pylori infection in patients with gastric cancer
Objective(s): KRAS proto-oncogene mutation can be considered a diagnostic factor for treating various malignancies. Helicobacter pylori infection, a risk factor for stomach cancer, may cause DNA damage and genetic changes. The aim of the current study was to assess the association of gastric cancer and KRAS mutation, demographic factors, and H. pylori infection.<...
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