محسن پورقاسم
استاد مرکز تحقیقات بیولوژی سلولی و مولکولی، دانشگاه علوم پزشکی بابل
[ 1 ] - اثر هشت هفته تمرین هوازی پس از پیوند سلولهای بنیادی مغز استخوان بر سطوح فاکتور رشد اندوتلیال عروقی و دوپامین جسم مخطط موش‌های مدل پارکینسون
هدف از پژوهش حاضر، بررسی اثر هشت هفته تمرین هوازی بر فاکتور رشد اندوتلیال عروقی و دوپامین جسم مخطط در موش‌های پارکینسونی، پس از پیوند سلولهای بنیادی مغز استخوان بود. بدین‌منظور، 35 موش صحرایی نر هفت هفته‌ای با وزن 300ـ250 گرم به‌صورت تصادفی به گروه‌‌های کنترل سالم، پارکینسونی کنترل، سلول‌درمانی، تمرین و سلول‌درمانی + تمرین تقسیم شدند. برای ایجاد مدل پارکینسونی، تخریب جسم مخطط با تزریق پنج می...
[ 2 ] - تغییر گلیکوزآمینوگلیکان‌ها در بافت مغز رت‌های دیابتی
چکیده مقدمه: دیابت ملیتوس بر متابولیسم اجزای ماتریکس خارج سلولی از جمله گلیگوز آمینوگلیگان‌ها مؤثر است. گرچه این تغییرها امروزه مورد توجه قرار گرفته، ولی تغییر گلیکوزآمینوگلیکان‌ها در بافت مغز رت‌های دیابتی، کمتر بررسی شده است. هدف: بررسی تغییرها گلیکوزآمینوگلیکان‌ها در مغز رت دیابتی. مواد و روش‌ها: در یک مطالعه تجربی، 20 سر رت از نژاد ویستار با وزن حدود 250-200 گرم به طور تصادفی به دو گروه ...
[ 3 ] - Time dependent of epigenetic effect of disulfiram on tumor suppressor gene of RASSF1A in Hela cancer cell line
Introduction: Cervical cancer is the third most common tumor among women. Surgery, radiotherapy, and chemotherapy are common treatments, however high stage tumors have frequently poor prognosis. Nowadays, the epigenetic reversion introduced as an efficient strategy of treatment of cervical cancer. In the process, inhibitors of DNA methyltransferase (DNMT) induce re-expression of tumor suppresso...
[ 4 ] - اثر تعاملی 8 هفته تمرین هوازی پس از تلقیح سلول های بنیادی مغز استخوان در جسم مخطط بر شاخص های رفتاری در موش های مدل پارکینسونی
زمینه و هدف: پارکینسون یک انحطاط پیشرونده دستگاه عصبی است که نورونهای دوپامینرژیک جسم سیاه تخریب و به دنبال آن مقادیر دوپامین در جسم مخطط کاهش مییابد.تلقیح سلولهای بنیادی و انجام تمرینات ورزشی از جمله راههای درمانی غیردارویی است که برای درمان این بیماری مورد توجه قرار گرفته است. هدف از پژوهش حاضر، بررسی اثر تعاملی 8 هفته تمرین هوازی پس از تلقیح سلولهای بنیادی مغز استخوان بر شاخصهای رفتاری...
[ 5 ] - An overview of Treatment options for urinary stones
Urolithiasis has become a worldwide problem with the prevalence of the disease increasing over the past few decades. While various treatment modalities have evolved over the years, discrepancies exist regarding the clinical indications and the efficacy of each of these treatment options. In the present review, we aim to review the current treatment modalities for urinary tract stones to provide...
[ 6 ] - Histological changes of kidney in diabetic nephropathy
Diabetes mellitus is the most common cause of chronic renal disorders and end-stage kidney disease in developed countries. It is the major cause of dialysis and transplantation. Failure in renal function causes wide disorders in the body. Diabetes results in wide range of alterations in the renal tissue. It is believed that early histological changes in diabetic nephropathy are detectabl...
[ 7 ] - Early Renal Histological Changes in Alloxan-Induced Diabetic Rats
Diabetes mellitus is a progressive disease. Most investigators have focused on glomerular changes in diabetic kidney and non-glomerular alterations have been less attended. The present study has been conducted to find early non-glomerular histological changes in diabetic renal tissue. Twenty male Wistar rats weighting 200-250 g were used for the diabetic group. Diabetes mellitus was induced by ...
[ 8 ] - Embryological Aspects of Oocyte In Vitro Maturation
In Vitro Maturation (IVM) is a method that immature oocytes in antral follicles are extracted and matured in laboratry conditions. This review has attempted to provide the current knowledge and recent findings in in vitro maturation of oocytes and highlights the most important factors involved in this process. The review is based on literature reports and the author’s experience. In IVM cycles,...
[ 9 ] - The Assessment of Early Glycosaminoglycan Concentration Changes in the Kidney of Diabetic Rats by Critical Electrolyte Concentration Staining
Glycosaminoglycan (GAG) has a pivot role in renal function and homeostasis. Analysis of GAG amount generally serves to determine GAG alteration due to diabetes mellitus. Critical Electrolyte Concentration (CEC) staining can be an efficacy method to study GAG amount changes. Based on an experimental study, 20 male rats were randomly divided equally into two experimental and control groups. Diabe...
[ 10 ] - A Modified Method for Cerebrospinal Fluid Collection in Anesthetized Rat and Evaluation of the Efficacy
Dear editor: We would like to present a modified method for cerebrospinal fluid collection in anesthetized rat. This method is easy and applicable in many laboratories interested by research on cellular and molecular effects of CSF on different pathways.
[ 11 ] - Comparison of skin reaction between MTA (produced in Iran) and CEM in Rabbit
Pathological changes in pulp and periapical tissues are addressed by endodontic treatment. The material used in this treatment must be biocompatible. The aim of this study is to compare the skin reaction of Calcium Enriched Mixture (CEM) and Mineral Trioxide Aggregate (MTA) produced in Iran on rabbit. Sixteen male newzeland albino rabbits weighting 2 kg were used. The animals back hair was sha...
[ 12 ] - Oral zinc sulphate and prevention of radiation-induced oropharyngealmucositis in patients with head and neck cancers: A double blind, randomized controlled clinical trial
Background: This research was conducted to evaluate the potential benefits of zinc sulphate in the prevention of radiation induced mucositis in patients who are being treated for head and neck cancers. Materials and Methods: Forty patients with proven cancers of head and neck were randomly divided into 2 equal groups that either received zinc sulphate or placebo (control group). Patients who re...
[ 13 ] - Practical Anatomy as an Advance Organizer for Anatomy Lectures: Effectiveness in Learning Facilitation for Dental Students
Introduction: Several approaches are introduced to facilitate anatomy learning. One of them is to present practical course before the theoretical one. This study compared the effect of presentation of practical class before lecture on enhancement of learning among dental students of Babol University of Medical Sciences. Methods: Thirty eight students of first semester in school of dentistry of...
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