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پژوهشگاه علوم وفنون هسته ای دانشکده مهندسی انرژی و فیزیک، دانشگاه صنعتی امیرکبیر
[ 1 ] - ارزیابی دز جذبی ترکیب لوتسیم-DOTA- تراستوزومب در اندام های بدن انسان براساس توزیع زیست شناختی آن روی موش های صحرایی
در این پژوهش، تراستوزومب با 177Lu نشاندار شد و مطالعات دزیمتری به منظور سنجش دز جذبی آن در اندام‌های بدن انسان انجام گرفت. کلرید لوتسیم با پرتودهی اکسید لوتسیم غنی شده با شار نوترون گرمایی 4×1013 cm-2 s-1 به مدت 7d در رآکتور تحقیقاتی تهران با فعالیت ویژه‌ی 70 تا GBq/mg 80 تهیه شد. ترکیب نشاندار لوتسیم-DOTA- تراستوزومب با خلوص رادیوشیمیایی بالاتر از 98% در شرایط بهینه‌ی نشان‌دارسازی به دست...
[ 2 ] - بررسی امکان استفاده از ترکیب عناصر سرب، تنگستن و باریم به منظور افزایش بازده ی روپوش های محافظ در تضعیف پرتوهای ایکس محدوده ی تشخیصی به وسیله ی کد MCNP
در این پژوهش، به منظور کاهش وزن و افزایش بازده‌ی روپوش‌های محافظتی در تضعیف پرتوهای ایکس محدوده‌ی تشخیصی، استفاده از عناصر تنگستن و باریم در ترکیب با سرب، مورد بررسی قرار گرفت. ابتدا دستگاه پرتو ایکس مستقر در مرکز تحقیقات تابش دانشگاه شیراز با استفاده از کد MCNP4C شبیه‌سازی شد و طیف خروجی پرتوهای ایکس ترمزی و مشخصه‌ی دستگاه به دست آمد. به منظور بررسی صحت شبیه‌سازی انجام شده با کد مونت‌کا...
[ 3 ] - Evaluation of the Possible Utilization of 68Ga-DOTATOC in Diagnosis of Adenocarcinoma Breast Cancer
Objective(s): Studies have indicated advantageous properties of [DOTA-DPhe1 , Tyr3 ] octreotide (DOTATOC) in tumor models and labeling with gallium. Breast cancer is the second leading cause of cancer mortality in women, and most of these cancers are often an adenocarcinoma. Due to the importance of target to non-target ratios in the efficacy of diagnosis, the pharmacokinetic of 68Ga-DOTATOC in...
[ 4 ] - Preclinical Studies of 68Ga-DOTATOC: Biodistribution Assessment in Syrian Rats and Evaluation of Absorbed Dose in Human Organs
Objective(s): Gallium-68 DOTA-DPhe1-Tyr3-Octreotide (68Ga-DOTATOC) has been applied by several European centers for the treatment of a variety of human malignancies. Nevertheless, definitive dosimetric data are yet unavailable. According to the Society of Nuclear Medicine and Molecular Imaging, researchers are investigating the safety and efficacy of this radiotracer to meet Food and Drug Admin...
[ 5 ] - Preparation, quality control and biodistribution study of 68Ga-BPAMD: Optimized production with an in-house 68Ge-68Ga generator
Introduction: Bone metastases are common in the progression of various tumors leading to severe pain and decrease in quality of life. The aim of this study was to optimize the production of 68Ga-BPAMD as an ideal bone imaging agent using an in-house 68Ge/68Ga generator for future clinical use. Methods: The optimized condit...
[ 6 ] - Preparation and biodistribution assessment of low specific activity 177Lu-DOTATOC for optimization studies
Introduction: Somatostatin receptors expressed on a wide range of human tumors, are potential targets for the peptide receptor radionuclide therapy (PRRT). In this study, 177Lu-[DOTA-DPhe1, Tyr3]octreotide (177Lu-DOTATOC) as an agent for PRRT was prepared and its biodistribution was studied in rats. Methods:The ...
[ 7 ] - Optimized production and quality control of 68Ga-DOTATATE
Introduction: Optimized production and quality control of 68Ga-DOTATATE as an efficient and preferable PET radiotracer for somatostatin receptor imaging in neuroendocrine tumors is of great interest. In this study effort has been made to present a fast, efficient, cost-effective and facile protocol for 68Ga-DOTATATE productions for clinical trials. Methods:68Ga...
[ 8 ] - Optimized preparation and evaluation of 99mTc-Streptomycin
Introduction: The endemic occurrence of new strains of tuberculosis around the globe has initiated new research on developing diagnostic radiopharmaceutical based on antibiotics. Methods:Tc-99m labeled streptomycin was prepared using freshly milked 99mTcO4- and various concentrations of streptomycin, stannous chloride at various temperatures in high yield radio...
[ 9 ] - Preclinical studies of 166Ho-chitosan for treatment of hepatocellular carcinoma
Introduction: Recently, due to the special characteristics of 166Ho and chitosan, 166Ho-chitosan complex was developed for treatment of tumors such as hepatocellular carcinoma. This complex has been lately prepared with high radiochemical purity in our lab. The preclinical studies of the complex however should be performed to evaluate the tracer concentration in target and...
[ 10 ] - Radiolabeling and evaluation of two 177Lu-labeled bis-phosphonates
Introduction: Bone pain palliation therapy is a mandate in handling end-stage cancer patients. The development of new ligands with higher stability, better pharmacokinetics and lower unwanted tissue uptakes (liver and GI) is still ongoing. Methods: In this work Lu-177 labeled (3-amino-1-hydroxypropane-1,1-di-yl)-bis-(phosphonate) (177Lu-pamidronate; 177Lu-PAM ), ...
[ 11 ] - Preparation and quality control of 177Lu-chitosan for radiosynovectomy
Introduction: Rheumatoid arthritis (RA) is the most common autoimmune disease, leading to the destruction of the joints and causing pain, disability, and immobility in the patients. Radiosynovectomy (RSV) has been applied as an effective treatment for the patients with resistant synovitis after failure of long-term pharmacotherapy and intra-articular steroid injection for more than 50 years. Se...
[ 12 ] - Production and quality control of 166Ho-Chitosan for therapeutic applications
Introduction: In this research, [166Ho]Holmium chitosan complex production is described in details, followed by determination of complex radiochemical purity, stability and biodistribution (after intra-articular injection) in wild-type male rats. Finally a Ho-166 based chitosan kit for ultimate radiosynovectomy as well as radiotherapy applications was developed. Methods: 166</s...
[ 13 ] - Preliminary imaging studies of [61Cu]diacetyl-bis (N4-methylthiosemi-carbazone) in normal and hypoxic tumor models
Introduction: [61Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([61Cu]ATSM) is a well-established hypoxia imaging tracer with simple production and significant specifity. In this work the accumulation of the tracer is studied in wild-type, necrotic and hypoxic fibrosarcoma tumors. Methods: [61Cu]ATSM was prepared u...
[ 14 ] - Development of Sm-153 chitosan for radiosynovectomy
Introduction: Developing new radiosynovectomy agents is of great importance due to the aging of human populations around the world and increasing the incidence of inflammatory diseases. In this work, Sm-153 chitosan agent was developed for the first time in our country and preparation and quality control of the compound is described. Methods: Sm-153 chloride was ob...
[ 15 ] - Preclinical evaluation of 68Ga-MAA from commercial available 99mTc-MAA kit
99mTc-Macroaggregated Albumin (99mTc-MAA) has been used as a perfusion agent. This study described development of the 68Ga-MAA via commercially available kits from Pars-Isotopes Company as a 99mTc-MAA kit. 68Ge/68Ga generator was eluted with suprapure HCl (0.6 M, 6 mL) in 0.5 mL fractions. The two fractions with the highest 68GaCl3 activity were generally used for labeling purposes. After label...
[ 16 ] - Preclinical evaluation of 68Ga-MAA from commercial available 99mTc-MAA kit
99mTc-Macroaggregated Albumin (99mTc-MAA) has been used as a perfusion agent. This study described development of the 68Ga-MAA via commercially available kits from Pars-Isotopes Company as a 99mTc-MAA kit. 68Ge/68Ga generator was eluted with suprapure HCl (0.6 M, 6 mL) in 0.5 mL fractions. The two fractions with the highest 68GaCl3 activity were generally used for labeling purposes. After label...
[ 17 ] - Human organ absorbed dose estimation of 166Ho-BPAMD complex based on biodistribution data of male Syrian rats
Introduction: Recently, 166Ho-BPAMD was introduced as a suitable agent for bone marrow ablation. The aim of this study was to estimate the absorbed dose of this novel agent in the human organs which is necessary before the clinical application. Methods: 166Ho was produced by direct irradiation of 165Ho in the research reactor. 250 µg...
[ 18 ] - Biological assessment and human absorbed dose estimation of [111In]In-DTPA-antiMUC1 as a radioimmunoconjugate for breast cancer imaging
Introduction: The aim of this study was to evaluate the human organ absorbed dose of [111In]In-DTPA-antiMUC1, as a newly developed radioimmunoconjugate. Methods: [111In]In-DTPA-antiMUC1 was prepared at optimized conditions while the radiochemical purity of the tracer was investigated using ITLC method. Biodistribution of the radiolab...
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