مقصود پیری
گروه فیزیوبوژی، دانشکده تربیت بدنی دانشگاه آزاد تهران مرکزی
[ 1 ] - تاثیر چهارده هفته فعالیت هوازی همزمان با مکمل‌دهی رزوراترول روی میزان پروتئین SIRT1 و UCP-1 و PGC-1α در بافت کبد ی، چربی زیر پوستی و چربی احشایی موش های صحرایی نر
هدف از تحقیق حاضر تعیین تاثیر مکمل‌دهی رزوراترول و فعالیت هوازی بر میزان پروتئین SIRT-1 ، PGC-1αو UCP-1 بافت کبدی و بافت چربی شکمی-کشاله‌ای و احشایی در موش‌های صحرایی نر بود. در این پژوهش 28 سر موش صحرایی (میانگین وزن10 ±260 گرم، سن 8 هفته)، به طور تصادفی به چهار گروه؛ شاهد (C)، تمرین (T)، مکمل-تمرین (T-S) و مکمل (S) تقسیم شدند. گروههای تمرینی به مدت 14 هفته (هفته ای 5 جلسه، هر جلسه به مدت 4...
[ 2 ] - تأثیر انواع تمرینات مقاومتی براشتها و سطوح سرمی اورکسین ،گرلین و نوروپپتید yدر مردان غیرفعال
مقدمه تمرینات مختلف بدنی از طریق تأثیربر هورمونهای تنظیم کننده اشتها نقش مهمی در تعادل انرژی و کنترل وزن ایفا میکنند. هدف این پژوهش تعیین تاثیر انواع تمرینات مقاومتی (بالا تنه، پایین تنه و ترکیبی) برمیزان اشتها و هورمونهای مرتبط با آن در افراد کمتحرک میباشد. روش کار چهل مرد جوان با میانگین سنی ۷/۰± ۱۵/۲۲ و شاخص توده بدنی ۵/۳± ۱۲/۲۴ به طور تصادفی در چهار گروه ۱) کنترل، ۲) تمرینات مقاومتی...
[ 3 ] - اثر حفاظتی تمرین هوازی بر سرطان پستان بواسطه پروتئین TGF-β و ژن Smad-3 و MMP2 در موش های ماده
زمینه و هدف: هدف از این تحقیق تعیین اثر حفاظتی تمرین هوازی بر سرطان پستان بواسطه پروتئین TGF-β و ژن Smad-3 و MMP2 در موش های ماده بود. روش بررسی: تعداد 24 سر موش ماده نژاد بالبسی پس از توموری شدن بوسیله رده سلولی MC4-L2 در قالب دو گروه تمرین تداومی هوازی و کنترل در شرایط استاندارد مورد مطالعه قرار گرفتند. برنامه تمرین تداومی هوازی شامل60 دقیقه دویدن روی تردمیل با شدت 65- 60 درصد VO2max، پنج...
[ 4 ] - تأثیر 12 هفته تمرین ورزشی منتخب در آب و مداخله داروی آتورواستاتین بر تغییرات پپتیدهای ناتریورتیک مردان دارای بیماری قلبی- عروقی
Background and Aim: The present study aimed at investigating the effect of a 12-week aerobic water exercise and atorvastatin on of Atrial Natriuretic Peptide (ANP) and Brain Natriuretic Peptide (BNP) changes in older men with cardiovascular diseases. Materials and Methods: In the current study, 40 patients with cardiovascular disease, aged 50-65yrs, who were volunteers for the research were di...
[ 5 ] - اثر نوع تمرین بر نشانگران آپوپتوز هپاتوسیتی در رتهای تغذیه شده با غذای پرچربب
Background:Anti-inflammation and anti-apoptotic effects of physical activity have been proven and its effectiveness depends on intensity, duration and type. Since obesity is considered as a mild chronic inflammation, it is reasonable that the degenerative damages occurin tissues, especially in the liver as the center of metabolism. The aim of this study was to investigate the effect of two typ...
[ 6 ] - Comparison of protective effect of two types of aerobic and intermittent training on breast cancer by TGFβ protein and Smad-3 gene and MMP2 in female mice
Introduction: The aim of this study was to compare the protective effects of two types of aerobic and intermittent training on breast cancer as a result of TGFβ protein, Smad-3, and MMP2 gene in female mice. Methods: In the experimental study, a total of 24 female BALB/c mice after Tumorigenesis by MC4-L2 cell line in the three groups; Control, Aerobic, and Intermittent training groups,...
[ 7 ] - تأثیر یک دوره تمرین تناوبی شدید و استقامتی تداومی بر بیان ژن‌های آدیپونکتین و TNF-α در رتهای مبتلا به دیابت نوع دو
هدف از پژوهش حاضر مقایسۀ تأثیر یک دوره تمرین تناوبی شدید و استقامتی تداومی بر بیان ژن‌های آدیپونکتین و TNF-α در رتهای مبتلا به دیابت نوع دو بود. 24 سر رت نژاد ویستار (وزن 10±160 گرم) پس از هفت ماه رژیم غذایی پرچرب و حاوی فروکتوز به سه گروه کنترل، تمرین تناوبی شدید و استقامتی تداومی تقسیم شدند و گروههای تمرین به مدت هشت هفته/ پنج روز هفته پروتکل تمرینی را اجرا کردند. بیان ژن آدیپونکتین و TNF-α...
[ 8 ] - تاثیر یک دوره تمرین داوطلبانه بر سطوح تستوسترون و کورتیکوسترون موش های صحرایی نر به دنبال استرس جدایی از مادر
اهداف: این پژوهش در نظر دارد تا تاثیر تمرینات ورزشی داوطلبانه در دوران نوجوانی را بر روی سطوح تستوسترون و کورتیکوسترون موش‌های صحرایی نر به دنبال استرس دوران کودکی مورد مطالعه قرار دهد. مواد و روش‌ها: در این پژوهش تجربی، 36 سر بچه موش بعنوان آزمودنی‌های تحقیق انتخاب شدند و از روز2 تا 14 به مدت 180 دقیقه از مادرشان جدا شدند. سپس برای تعیین گروههای تجربی و کنترل، در روز 21 این موش‌ها به صورت ت...
[ 9 ] - Exercise during adolescence attenuated depressive-like behaviors and hippocampal mitochondrial dysfunction following early life stress in adult male rats
Purpose: In this study, we assumed that treating animals with an antidepressant agents or voluntary running wheel exercise (RW) during adolescence may have protective effects against early life stress (ELS) which can impact on behavior and mitochondrial function. Evidence indicates that ELS has deleterious effects on brain and behavior and increases the risk of mental disorders such as depressi...
[ 10 ] - Exercise during adolescence attenuated depressive-like behaviors and hippocampal mitochondrial dysfunction following early life stress in adult male rats
Purpose: In this study, we assumed that treating animals with an antidepressant agents or voluntary running wheel exercise (RW) during adolescence may have protective effects against early life stress (ELS) which can impact on behavior and mitochondrial function. Evidence indicates that ELS has deleterious effects on brain and behavior and increases the risk of mental disorders such as depressi...
[ 11 ] - تأثیر چهار هفته تمرین ورزشی داوطلبانه بر رفتار شبه‌افسردگی ناشی از استرس دوران کودکی و استرس اکسیداتیو موش‌های صحرایی
هدف پژوهش حاضر بررسی تأثیر چهار هفته دویدن اختیاری روی چرخ دوی گردان در دوران نوجوانی بر رفتار افسردگی و تأثیر آن بر میزان استرس اکسیداتیو در مخچه است. به همین منظور 24 سر موش نر به‌صورت تصادفی به سه گروه کنترل، جداشده از مادر (MS) و جداشده از مادر و دویدن اختیاری (MS+RW) تقسیم شدند. موش‌های گروه MS و MS+RW از روز دوم پس از تولد تا روز چهاردهم به مدت 180 دقیقه از مادرشان جدا شدند. سپس آزمودنی...
[ 12 ] - The effect of 4-weeks voluntary exercise on separation anxiety disorder in rats
Background: Separation anxiety is the most common anxiety disorder in children. The neglected treatment of this disorder at early ages may be a risk factor for other childhood and adult psychological disorders. The early years of life are considered to be one of the most critical stages of human development and any physical or psychological damage will cause the effects on sustainability in oth...
[ 13 ] - تاثیر یک دوره تمرین هوازی اجباری در دوران نوجوانی بر اثرات منفی استرس جدایی از مادر بر استرس اکسیداتیو قلبی در رت های نر بالغ
زمینه و هدف: استرس زودرس به عنوان عامل خطر توسعه افسردگی و آسیبهای مرتبط با آن شناخته شدهاست. کاردیومیوپاتی نقش مهمی در پاتوفیزیولوژی افسردگی و بیماریهای قلبی - عروقی بازی میکند. شواهد نشان میدهد که فعالیت بدنی منظم در دوران نوجوانی ممکن است بتواند اثرات منفی استرس جدایی از مادر را به عنوان یک مدل حیوانی معتبر افسردگی بر رفتار و عملکرد میتوکندریایی قلبی رتهای بالغ تعدیل ک...
[ 14 ] - The Therapeutic Effect of Exercise on Anxiety and Bowel Oxidative Stress in the Maternal Separation Animal Model
Introduction: According to evidence, Early-Life Stress (ELS), mood disorders, and medical comorbidities, i.e. Irritable Bowel Syndrome (IBS), are correlated; however, the direct contribution of ELS to IBS manifestations is less understood. The current study aimed at evaluating the effect of voluntary exercise on the mitochondrial dysfunction of the bowel fibroblasts, following the confirmation...
[ 15 ] - Antiapoptotic and antioxidant effects of resistance training with berberine consumption on diazinon induced cardiotoxicity in rats
Background: Increasing use of pesticides is one of the health hazards. Physical activity and medicinal plants appear to be a strategy to mitigate the adverse effects of these substances. Objective: The purpose of this study was to investigate the effect of resistance training and berberine chloride on apoptosis and oxidative stress markers in the heart tissue of diazinon-infected rats. Methods:...
[ 16 ] - Dietary supplementation with Salvia officinalis L. and aerobic training attenuates memory deficits via the CREB-BDNF pathway in amyloid beta- injected rats
Background: AD is a neurodegenerative disorder in which there is a gathering of beta-amyloid plaques, primarily in the hippocampus, that lead to neuronal death. Exercise training and botanical medications can play a role in the prevention and treatment of neurodegenerative disorders. Objective: The aim of this study was to determine the effects of aerobic training and Salvia officinalis extract...
[ 17 ] - Improvement of Learning and Memory Deficits With Aerobic Training and Donepezil Co-therapy in Amyloid-β Injected Male Rats Through the CREB And BDNF Signaling Pathway
Background: Accumulation of amyloid-β (Aß) plaques, primarily in the hippocampus, leads to neuronal death and Alzheimer disease. Exercise and medications can prevent and treat neuronal diseases. This study aimed to determine the effects of aerobic training and donepezil, a medication used in Alzheimer disease, on the improvement of learning and memory deficits in Aß-injected male rats. Methods...
[ 18 ] - تاثیر تمرین هوازی به همراه مکمل یاری ویتامین D بر بیان ژن های آپوپتوزیس BCL2 ،BAX ، کاسپاز-3 و نسبت BCL2/BAX در ریه رت های نر مسموم شده با آب اکسیژنه
زمینه و هدف: ورزش یک محرک فیزیولوژیک قوی است که می تواند با تاثیر بر روی تعدادی از مسیرهای پیام دهی خارج سلولی و داخل سلولی به طور مستقیم یا غیرمستقیم بر روند آپوپتوزیس ریه اثرگذار باشد. هدف تحقیق حاضر، بررسی تاثیر تمرین هوازی و ویتامینD بر بیان ژن های آپوپتوزیس کاسپاز-3، BCL2،BAX و نسبت BCL2/BAX در ریه رت های نر مسموم شده با آب اکسیژنه بود. روش تحقیق: در این مطالعه 48 سر موش نر بالغ ویستار ...
[ 19 ] - Effect of 10 Weeks of High-Intensity Interval Training on Protein Levels of NF-kB and Expression of Atrogin-1 and MuRF-1 in Cardiomyocytes of Female Mice with Breast Cancer
Introduction: Limiting cancer-induced cardiac atrophy is a highly important for improving the survival rates and quality of life in cancer patients. The purpose of this study was to evaluate the effect of 10 weeks of high-intensity interval training (HIIT) on cardiac muscle weight, NF-kB protein expression, and expression of Atrogin-1 and MuRF-1 genes in the heart muscle of breast cancer–bearin...
[ 20 ] - THE EFFECT OF ENDURANCE EXERCISE TRAINING AND OCTOPAMINE SUPPLEMENTATION ON NLRP1 INFLAMMASOME, PI3K, APOPTOSIS, AND HISTOPATHOLOGICAL CHANGES IN HEART TISSUE OF RATS POISONED WITH DEEP-FRIED OIL
Background & Aims: Common nutritional mistakes cause inflammation and homeostasis disruption in heart cells. Inflammasome complex is one of the pathways that induces inflammation and degradation of cardiac protein regeneration. The aim of the present study was to investigate changes in NLRP1inflammasome, PI3k, apoptosis, and histopathology of heart tissue following aerobic physical activity and...
[ 21 ] - Effects of a Single Session of Eccentric or Concentric Resistance Exercise on Relative Expression of BDNF, PAX7 and IGF-1 in Young Men
Background and Objectives: The aim of the present study was to investigate effectsof a single sessionof eccentric or concentric resistance exercise on relative expression of BDNF, PAX7 and IGF-1 in healthy participants. Materials and Methods: In a field trial, ten healthy young men were randomly assigned into two equal groupsof concentric and eccentric contractions. Isokinetic contraction prot...
[ 22 ] - Effect of 6 weeks of resistance exercise preconditioning on mitochondrial dynamics in cardiac tissue of diabetic rats
Background and Objectives: Diabetic cardiomyopathy refers to changes in the heart as a result of altered glucose homeostasis, leading to ventricular dysfunction, and it is associated with the mitochondrial abnormality. Since physical exercise has been known as cardioprotective, the aim of the present study was to investigate the effect of 6 weeks of resistance exercise preconditioning on mitoch...
[ 23 ] - The Effect of a Course of Aerobic Exercise With Hypoallergenic Supplement of Tribulus Terrestris on Mitochondrial Oxidative Stress Markers of Cardiac Tissue in Rats Toxicated With Hydrogen Peroxide
Introduction: Oxidative stress causes DNA damage and apoptosis and leads to cardiovascular disease. The aim of this study was to evaluate the effect of a course of aerobic exercise with hypoallergenic supplement of Tribulus terrestris on mitochondrial oxidative stress markers of cardiac tissue in rats toxicated with hydrogen peroxide. Method: To implementation of this experimental research, 4...
[ 24 ] - The Effect of Resistance Training and Berberine Chloride on the Apoptosis-Related Unfolded Protein Response Signaling Pathway in the Hippocampus of Diazinon-Poisoned Rats
Introduction: Diazinon is one of the most widely-used organophosphate pesticides in the world. This toxin enters the body in various ways and induces oxidative stress in various tissues. It has been proved that activation of unfolded protein response (UPR) under oxidative stress is a steady mechanism for maintaining cell function and survival. Therefore, the present study aimed to review the ef...
[ 25 ] - The effect of circuit resistance training with 40, 60 and 80 percent of one-repetition maximum on the levels of IL-10, IL-1β and body fat percent in obese postmenopausal women
Introduction: Adipose tissue plays an important role in increasing systemic inflammation and exercise training result in modulating inflammation by decreasing adipose tissue. The present study aimed to investigate the effect of 12 weeks circuit resistance training with 40, 60 and 80 percent of one-repetition maximum (1RM) on the levels of IL-10, IL-1β and body fat percent in obese postmenopausa...
[ 26 ] - The effect of 4 weeks of endurance training and eugenol consumption on the expression of Gap43 and E-cadherin genes in the heart tissue of chlorpyrifos-poisoned mice
1.Introduction Among the various tissues of the body, the heart is one of the main and most important organs of the body to which human life depends, and any tissue and physiological damage to it disrupts human health (10) . On the other hand, today, prescribing sports activities is accepted as an effective prescription in the prevention and treatment of many diseases and improving heart f...
[ 27 ] - The effect of resistance training and date pollen extract on bone tissue density and osteoblast cell proliferation in young male rats
Extended Abstract 1.Introduction One of the tissues that is affected by physical activity is bone. Bone is one of the tissues that needs to receive mechanical load to have normal function as a key factor in strengthening bone mass (2). Evidence shows that the mechanical load resulting from physical activity activates a set of proteins involved in the process of osteoblast activation and inhib...
[ 28 ] - Effect of 4 Weeks of High Intensity Interval Training with Curcumin Supplementation on COL-I, COL- II, SMAD3 Gene Expression in the Myocardium of Obese Male Rats with Type 2 Diabetes
Introduction: The aim of this study was investigating the effect of 4 weeks of high intensity interval training with curcumin supplement on the gene expression of collagen I, II and SMAD/3 in the myocardium of male obese rats with type 2 diabetes. Methods: In this experimental study, 35 male diabetic rats were divided in to 5 groups of seven; normal control, diabetic control, curcumin+diabeti...
[ 29 ] - The effect of phytochemical compounds on indicators of oxidative stress, inflammation and skeletal muscle damage caused by physical activity
Physical activities are associated with increased production of reactive oxygen species. The production of reactive oxygen species is dependent of the intensity, duration and type of activity. Although the physiological amounts of reactive oxygen species are necessary to regulate cell reactions, their excessive production can cause numerous damages to the structure and function of cells and wea...
[ 30 ] - The effect of one course circuit resistance training with different intensity on the levels of Myd88, TLR2 and TLR4 in obese postmenopausal women
Introduction: Tol-like receptors (TLRs) play an important role in inducing inflammatory insulin resistance, and modulating their levels is effective in improving insulin resistance. The aim of this study was to evaluate the effect of one course circuit resistance training with different intensity on the levels of Myd88, TLR2 and TLR4 in obese postmenopausal women. Method: 44 postmenopausal wom...
[ 31 ] - The Effect of Aerobic Training and Tribulus Terrestris Extract on Muscle Atrophy Indices and Oxidant-Pro-Oxidant Balance in Extensor Digitorum Longus Muscles of Type 2 Diabetic Desert Rats
Background & Aims: Performing normal daily activities requires sufficient muscle size and strength, and atrophy has a negative effect on the overall quality of life; So that the decrease in skeletal muscle mass leads to a decrease in human performance, long-term health and low quality of life. Diabetes is associated with the development of secondary complications in various organs, especially s...
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