Brosens JJ

[ 1 ] - I-32: Implantation and Recurrent PregnancyLoss

Background: Recurrent pregnancy loss (RPL), defined as 3 or more consecutive pregnancy failures, is a common and distressing disorder. Chromosome instability in the conceptus is the most common cause whereas uterine factors are invariably invoked to explain nonchromosomal miscarriages. These uterine factors are, however, poorly defined. Materials amd Methods: Laboratory-based analysis of endome...

[ 2 ] - I-33: Oxidative Stress Responses in EarlyPregnancy

Background: Survival of the conceptus is dependent on continuous progesterone signaling in the maternal decidua but how this is achieved under conditions of oxidative stress that characterize early pregnancy is unknown. Materials and Methods: Laboratory-based analysis of endometrial biopsies and primary endometrial cultures. Results: Using primary cultures, we show that modest levels of reactiv...

[ 3 ] - I-34: Steroid Hormone Signalling at the FetomaternalInterface

Background: Progesterone is indispensable for differentiation of human endometrial stromal cells (HESCs) into decidual cells, a process that critically controls embryo implantation. However, HESCs also abundantly express androgen receptors (AR), yet the role of this member of the superfamily of ligand-dependent transcription factors in the decidual process remains poorly elucidated. Materials a...