Simpson JL

[ 1 ] - I-41: Genetic Causes of Premature Ovarian Failure (POF) and early Menopause

Premature ovarian failure (POF) is a heterogeneous disorder, defined as menopause under age 40 years. The prevalence is 1%; POF before age 30 years is much less common. Chromosomal causes have long been recognized - visible deletions of the X chromosome, 45,X/46,XX mosaicism, and autosomal rearrangements (balanced translocations). Toxins or iatrogenic causes (e.g., chemotherapeutic agents) are ...

[ 2 ] - I-42: Do Birth Defects Increase with Assisted Reproductive Technologies

Assisted reproductive technologies (ART) like in vitro fertilization have enabled many infertile couples to achieve pregnancy. Although ART pregnancies have long been known to be characterized by increased rates for certain maternal complications, these complications are predictable based on the mother’s more advanced age - increased medical complications like hypertension or diabetes mellitus....

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