Cheraghi SH

[ 1 ] - P-96: Appositional Expressions of Cyclin D1 and E2F1 Gene Machineries in Mycooestrogen Zeralenone-Induced Apoptosis in Testicular Tissue of Rats

Background: Zearalenone (ZEA) is known as a nonsteroidal oestrogenic mycotoxin produced by different species of Fusarium fungi. ZEA is known for its competitive effects with the natural 17-β estradiol to bind with the specific binding sites of the estrogen receptors (Ers). On the other hand, the cyclin family (especially cyclin D1) and E2F1 genes are the checkpoint genes involved in cell cycle....

[ 2 ] - P-185: Hawthorn Berries Ethanolic Extract Lowered Polycystic Ovarian Syndrome- Elevated RNA Damage in Follicular Cells

Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder. Various constituents including flavonoids with biological activities including free radical scavenging, anti-lipoperoxidation and anti-inflammatory have been isolated from hawthorn. Due to adverse effect of PCOS on ovarian vascular remodeling as well as PCOS-induced oxidative stress, we aimed to study the hawthorn’s berri...

[ 3 ] - O-2: Testosterone and Vitamin E administration Up-Regulates Hsp70 Protein Expression in Varicocele-induced Rats; Correlation with Leydig Cells Steroidogenesis and Germinal Cells RNA Damage

Background: Varicocele (VCL) impacts the testicular tissue partly by down-regulating the antioxidant status accomplished with reducing the intra-testicular endocrine potential. It has been reported that the HSP70 families play a critical role in spermiogenesis. Therefore, current study was aimed to evaluate the protective effect of exogenous testosterone and vitamin E administration on VCL-indu...

[ 4 ] - O-33: Nanosilver Impacts The Testicular Tissue by Reducing The GLUT I Expression in Leydig Cells; Correlation with Germinal Cells RNA Damage

Background: Nanosilver (NS) contains silver nanoparticles to control infections delivered from bacteria. The NS compounds as well as being toxic to prokaryotes are highly toxic to mammalian cells. The present study was evaluated the effect of colloidal NS on leydig cells glucose transporter type I (GLUT I) expression, serum level of testosterone, germinal cells RNA damage and spermiogenesis pro...

[ 5 ] - P-31: Dexamethasone and Vitamin E Up-Regulated The Varicocele-Reduced Hsp70 Protein Expression; Correlation with Testicular Tissue Inflammation and Antioxidant Status

Background: The varicocele (VCL) impacts the testicular tissue both by enhancing tissue inflammation and by down-regulating the antioxidant status. On the other hand, in varicocele patient the critical role of Hsp70 in spermiogenesis is identified. Therefore present study was estimated to evaluate the protective effect of testosterone and vitamin E on VCL-decreased Hsp70 expression and on VCL-i...

[ 6 ] - O-4: Protective Effect of Silymarin on Sperm Viability and Chromatin Packing in Varicocele-Induced Rats

Background: Varicocele has been repeatedly implicated as a cause of infertility in selected men. Previous studies have showed high levels of seminal oxidative stress, as evidenced by increased levels of ROS and reduced total antioxidant capacity in varicocele men, suggesting that sperm dysfunction in varicocele patients may be partly related to oxidative stress. Thus current study was designed ...

[ 7 ] - O-24: Increased Homocysteinein PCOS Affects Oocyte and Embryo Quality

Background: The biochemical characteristics of the follicular fluid (FF) play essential role in oocyte quality, the subsequent fertilization potential and embryo development. The oocyte quality and metabolism largely depends on follicular microenvironment. Present study aimed to investigate the relationship between oocyte quality and FF homocysteine (Hcy) level in women undergoing to IVF treatm...

[ 8 ] - P-31: Chronic Exposure to Imidacloprid Reduced Sperm Content, Motility and Viability

s:2011:"Background: Imidacloprid (IMD) is a systemic insecticide which acts as an insect neurotoxin and belongs to a class of chemicals called the neonicotinoids which act on the central nervous system of insects. According to previous studies, IMD is rated as "moderately toxic" on an acute oral basis to mammals and according to United States Environmental Protection Agency this compound is cla...

[ 9 ] - P-37: Effect of Gibberellic Acid on Sperm DNA Double Strand Integrity, Nuclear Maturity and Motility

Background: Plant growth regulators gave entry into animals and human cells through diet. Gibberellic acid (GA3) is an extensively prevalent plant growth regulator due to its use in agriculture. Therefore current study was designed to investigate the effect of GA3 compound on sperm DNA integrity, nuclear maturity and motility. Materials and Methods: To follow-up current study 12 mature male s r...

[ 10 ] - P-56: Silymarin Protected The Sperm Nuclear Maturity and DNA Integrity in Varicocelized Rats

Background: Varicoceles are the abnormal tortuosity and dilatation of the veins of the pampiniform plexus that drain the testis. Recently, studies evaluating the role of oxidative stress in male infertility have shown that infertile men with varicocele have elevated levels of sperm and testicular tissue-derived reactive oxygen species (ROS). Therefore current study was designed to evaluate prot...

[ 11 ] - P-63: Chronic Exposure to Gly-Phosate; Evidence for Testicular Toxicity and Sperm Parameters

Background: Glyphosate (GPT) is a broad-spectrum systemic herbicide used to kill weeds, especially annual broadleaf and grasses known to compete with commercial crops grown around the globe. According to United States environmental protection agency the chemical has been reported as a third class toxin. Present study was designed in order to evaluate GPT-induced detrimental effects on testicula...

[ 12 ] - P-64: Germinal Cells Intracytoplasmic Carbohydrate,Lipid and Lipase levels Alter in Longtime Varicocele-Induced Rats

Background: Despite several studies many questions remain regarding how varicocele develops its adverse effect on testicular tissue. Spermatogenesis cell lineage needs carbohydrates as a main source of energy for cell division. Any disruption in glucose transporting system in seminiferous tubules results in remarkable decrease in germinal cells biological function. Therefore present study was c...

[ 13 ] - P-65: Nitrosative Stress, Lipid and Carbonyl Groups Peroxidations in Long Time-Induced Varicocele; Association with Sperms DNA Damage in Rats

Background: The pathophysiology of the varicocele has received considerable study, both in humans and in animal models. The sperm DNA damage and related oxidative stress have been identified as significant cause of male infertility. Present study was designed to evaluate the testicular nitric oxide (NO) generation, lipid and carbonyl groups (CGs) peroxidation and to analyze related sperm DNA da...

[ 14 ] - P-66: Protective Effect of Testosterone and Vitamin E on Atrazine-Induced Toxicity in Testis

Background: Atrazine (ATR) is herbicide which is known to induce endocrine disruption. According to previous reports, long-time exposure to ATR leads to severe seminiferous tubules degeneration and significant reduction in sperm content. Moreover this chemical exerts its pathological impact partly by inducing oxidative stress. Therefore present study was designed in order to evaluate protective...

[ 15 ] - P-161: Independent to Glucose and E2 the PCOS Women Show Significantly Higher Hemocysteine Level versus non PCOS

Background: Hyperhomocysteinemia is a recognized risk factor for atherosclerosis. Elevated homocysteine (Hcy) results in severe oxidative stress, platelets hyper activity, and impairs arterial circulation and smooth muscle proliferation in vascular wall. This study was carried out to evaluate follicular fluid (FF) Hcy, glucose and estradiol levels in IVF candidate PCOS women. Materials and Meth...