Movahed E
[ 4 ] - P-58: Mast Cells in Interstitial Tissue in The Testis of Male Rats Treated with Acyclovir
Background: Acyclovir (9-(2-hydroxyethoxymethyl) guanine) (ACV) is an acyclic nucleoside analogue that has shown a potent antiviral activity, and it is known to inhibit the replication of herpesviruses including herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), varicella- zoster virus (VZV), and Epstein-Barr virus (EBV) in cell cultures and in animals. ACV is khown to be toxic to gonads,t...
[ 5 ] - P-188: Mammary Gland Changes during Chlorpromazine Treatment in Female Rats
Background: Antipsychotic drugs are medications used to treat schizophrenia and other psychotic disorders. Antipsychotic drugs can cause unwanted side effects. Hyperprolactinemia is an important but neglected adverse effect. The aim of the this study was to consider the effects of Chlropromazine -induced hyperprolactinaemia on mammary glands of female rats . Materials and Methods: In this study...
[ 6 ] - P-230: Low Pregnancy Rate in Female Rats Mated by Male Rats Exposed to Acyclovir
Background: Acyclovir [9-(2-hydroxyethoxymethyl)guanine; ACV], an acyclic nucleoside analogue, has shown a potent antiviral activity. It is known to inhibit the replication of herpes viruses including herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), varicellazoster virus, and Epstein-Barr virus in cell cultures and in animals. ACV is khown to be toxic to gonads,then the aim of the presen...
[ 7 ] - P-51: A Purine Nucleoside Analogue_Acyclovir Impairs Testicular Functions in Male Rats
Background: Acyclovir (ACV) is a synthetic purine nucleoside analog drived from guanosine. ACV possesses antiviral activity against Herpes Simplex Virus types 1 and 2 (HSV-1 and HSV-2 ), Varicella Zoster virus (VZV) , Epstein Barr virus (EBV) and Cytomegalovirus (CMV). ACV exert its effects by interfering with DNA synthesis,thus inhibiting viral replication. ACV is khown to be toxic to gonads,t...
[ 8 ] - P-52: Acyclovir Induced Sperm and Hormonal Disorders in Male Rats
Background: Acyclovir is asynthetic purin nucleoside analog,which has been reported to be very effective against the treatment of herpes simplex and varicella zoster infections. Acyclovir is known to be toxic to gonads, but available literature fails to provide the indepth analyses of damage.The aim of the present study was to evaluate the effect of Acyclovir on DNA damage and nuclear maturatio...
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