Salvatore Gizzo
Woman and Child Health, University of Padua, , Padua, Italy
[ 1 ] - O-24: Single Oocyte Secretoma Mapping by NMR-Metabolomics Technology: A Non-Invasive Strategy to Select The Best Oocytes to Fertilize Avoiding Supernumerary Embryos and Increasing Take- Home-Baby-Rate after IVF
Background Current strategies based on random selection of MII-oocytes to fertilize appear unsatisfactory in selecting the best number and the most vital oocytes to fertilize especially in poor responder women in which “chronological age” does not mismatch with “biological age”. The metabolomics- profiling approach, evaluating the final products of cell regulatory process (genome/transcriptome/...
[ 2 ] - O-25: Serum Stem-Cell-Factor Assay in Elderly Poor Responder Patients Undergoing IVF: A New Biomarker to Customize Follicle Aspiration Cycle by Cycle.
Background Since the success rate in older poor-responder (POR) infertile women is expected to be extremely low irrespective of the treatment protocol, clinicians continue the search for biomarkers which may predict cases in which proceeding with follicle aspiration may be appropriate. Experimental studies on murine model suggest that SCF(Stem- Cell-Factor) produced by ovarian cumulus granulosa...
[ 3 ] - O-26: Effects of Recombinant-LH Supplementation on The Proteomic Profile of Follicular Fluid from Poor Responder Patients: Focus on Follicular Growth Factors and Oocyte Maturity Markers
Background Poor and fragmentary data was available regarding the effects of recombinant-LH (r-LH) in in-vitro granulosa and theca cells of human origin. No data was available from in vivo studies regarding the effects of r-LH supplementation on SCF,EGF,ERK-1/2 and AKT-1 pathways in the follicular fluid of older-poor-responder women undergoing IVF cycle. Evidence from in-vitro and animal studies...
[ 4 ] - O-27: Low Dose Aspirin Administration During IVF: Molecular Changes Potentially Involved in Detrimental Effects on Oocytes Maturation and Fertilization Rate
Background The hypothesis that the LDA (low-dose-aspirin) could improve ovarian and uterine perfusion induced clinicians to administer it in women undergoing IVF. Unfortunately, no studies have shown significant differences in terms of pregnancy rate among patients treated or untreated with LDA. The absence of proven clinical benefits of LDA supplementation, led us to wonder whether aspirin, ad...
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