M Shahhoseini
Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR,Tehran, Iran
[ 1 ] - I-43: Expression Profile of Macrophage Migration Inhibitory Factor (MIF) Signaling Pathway as A Potentional Biomarker in Pathophysiology of Endometriosis
Background MIF via its receptor, CD74, initiates a signaling cascade that leads to proliferation and survival of cells. Also, MIF binding to CD74 activates p38 signaling pathways that lead to positive effect on the expression of COX-2. The aim of this study was to evaluate the gene expression profile of MIF, CD74 and COX-2 in normal, ectopic and eutopic endometrium during menstrual cycle. The e...
[ 2 ] - O-21: Differential Expression and Epigenetic Pattern of HOX Family Genes in Cumulus Cells of Mature MII Oocytes from Patients with Polycystic Ovary Syndrome
Background Ovarian tissue cryopreservation represents a promising strategy to preserve the ovarian function in cancer patients. It is usually performed by slow freezing/rapid thawing (SF/RT). Recent studies emphasize an ultrarapid cryopreservation procedure, vitrification/warming (V/W), since it might prevent damages due to ice crystal formation. Comparative studies between the cryopreservation...
[ 3 ] - O-28: Role of HOX Family Related Genes in Pain Generation of Endometriosis Patients
Background Endometriosis is a common gynecological disease, can cause severe pelvic pain. Studies demonstrated the presence of sensory nerve fibers in endometrium of endometriosis patient. Nevertheless, no information is available on mechanisms of sensory nerve formation in eutopic or ectopic lesions. Since HOX genes have important roles in both reproductive tract and nerve growth, we decided t...
[ 4 ] - O-29: Aberrant Methylation of Lysine 9 on Histone 3 in PII Promoter of CYP19A1 Gene in Women with Endometriosis
Background Cytochrome aromatase p450, encoded by the gene CYP19A1, is a key enzyme for estrogen biosynthesis. Among the multiple promoters of CYP19A1, the proximal promoter PII is the most active ones in ovary and endometrium. Endometriosis is a chronic estrogen dependent gynecological condition characterized by the presence of ectopic glands and stroma outside the uterine cavity. Recently, evi...
[ 5 ] - P-84: Evidence for Differential Expression of The Pluripotency Factors c-MYC, KLF4 and LIN28 in Normal Endometrium and in Endometriosis
Background Endometriosis is a common gynecological disease characterized by the presence of endometrial tissue outside the uterine cavity. This disease affects approximately 10% of women in reproductive age and is associated with pelvic pain, dysmenorrhea and infertility. The theory of involvement of stem cells is a considered new hypothesis in etiology of endometriosis.The aim of this study wa...
[ 6 ] - P-86: Evaluation of Telomere Length, Telomerase and Telomeric Repeat Containing RNA (TERRA) Expression Levels in Cumulus Cells of PCOS Patients
Background Polycystic ovary syndrome (PCOS) is one of the reasons of infertility in women with chronic anovulation. Ovulation process is tightly regulated by molecular mechanisms controlling proliferation/differentiation of cells. Telomeres, TTAGGG tandem repeats, are transcribed into a non coding RNA, named TERRA. Recent studies suggest that TERRA sustain several important functions at chromos...
[ 7 ] - P-106: Comparative Expression of The Stemness Gene Oct-4, Nanog, Sox-2 and Rex-1 in Normal Endometrium and in Endometriosis
Background Endometriosis is a gynecological disease defined as the presence of endometrial tissue outside the uterine cavity, which caused by various factors. Recent evidences support the presence of endometrial stem cells and their possible involvement in endometriosis. Related studies mainly focus on stemness-related genes, and pluripotency markers may play a role in the etiology of endometri...
[ 8 ] - P-116: Absence of JMJD1A, A Testis- Specific Histone Demethylase, in Tissue Samples of TESE Negative Men
Background During mammalian spermatogenesis unique and dynamic epigenetic events occur leading to chromatin condensation. Through these events, histone demethylases such as JMJD1A play important roles in compaction of sperm chromatin, due to regulation of histone methylation dynamics and alteration of chromatin structure. As �histone methylation� is one of the best-characterized modifications i...
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