Ali Reza Saeeidinia
Faculty of Chemistry and Chemical Engineering, Malek Ashtar University of Technology, Iran.
[ 1 ] - Molecular Docking and In Silico Study of Denileukin Diftitox: Comparison of Wild Type With C519S-Mutant
Background: Denileukin diftitox (trade name, Ontak) is the first recombinant immunotoxin (IM), in which the binding domain of diphtheria toxin has been replaced by the amino acid sequence of human interleukin-2 (DT389IL-2) using genetic engineering. Purity, stability, and structural property of the protein are critical factors for the scale-up production of this fusion protein. In this IM, loca...
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