Khashei, Khalil
Islamic Azad University
[ 1 ] - Effect of curcumin on growth inhibition and gene expression reduction in chronic lymphocytic leukemia cells (CLL-CII)
Introduction: Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in adults living in Western countries. with a diverse clinical course that due to life expectancy less than two years between patients finding ,new therapeutic strategies is essential for it. Curcumin as the biologic active of turmeric, has many biological properties such as anti-inflammatory, anti-oxidant, anti-diab...
[ 2 ] - Association between Catalase Gene (CAT-262 C/T) Polymorphism and Preeclampsia in the South of Iran
Introduction: The cause of preeclampsia has not been identified so far; therefore, it accounts for a high percentages of maternal hospitalization. It seems that polymorphisms of genes encoding antioxidant system enzymes are effective in the pathophysiology of this disorder. This study aimed to evaluate the relationship between CAT-262 C/T polymorphism of enzymatic antioxidant Catalase gene and ...
[ 3 ] - Association of IL-19 Gene Polymorphism (rs2243191T / C) with occurrence of preeclampsia in pregnant women
Introduction: Preeclampsia, the most common, yet unknown, pregnancy-related disease, is the leading cause of maternal mortality worldwide. Increased systemic inflammatory factors as a result of decreased serum levels of anti-inflammatory cytokines during pregnancy have made inflammation a key role in preeclampsia. In the present study, the relationship between the interleukin 19 polymorphism as...
[ 4 ] - Association between Glutathione peroxidase1 gene (GPX1pro198Leu) polymorphism with preeclampsia in south of Iran
Introduction: Preeclampsia is a common and serious hypertensive disorder affecting approximately 5-8 % of pregnancies. The biology of the disease is complex and not understood. This disease associated with increased blood pressure more than 140/90 mmHg in the second half of pregnancy and proteinuria more than 300 mg/24 h and is considered as one of the three leading causes of maternal and fetal...
[ 5 ] - A Case Report of a Second-Trimester Stillbirth in a Pregnant Woman with SARS-CoV-2 Infection
The most important risk factors for fetal health in humans are maternal infections, that the majority of which are caused by viral agents. Viruses are one of the most contagious infectious agents that can cause many complex and irreversible complications, including; growth disorders, calcification, microcephaly, and fetal death. Recently, with the outbreak of the novel coronavirus (SARS-CoV-2),...
[ 6 ] - Accuracy of REP-PCR method in genotyping of Enterococcus fascia isolated from red meat as a cause of foodborne infections
Background: Increasing food consumption outdoors in different societies has raised the risk of transmission of foodborne pathogens as a global health problem. Molecular typing methods such as REP-PCR produced DNA profiles for differentiation and characterization of pathogenic strains. The aim of this study was to evaluate the accuracy of molecular fingerprinting method based on repeated sequenc...
[ 7 ] - Achieving Effective Treatment Goals against New Coronavirus (SARS-CoV-2) by Identifying the Molecular Details of the Virus Genome
Introduction: We are currently faced with a global epidemic of a new coronavirus (SARS-CoV-2) that It affects not only thousands of people in China, but all over the world. The rapid increase in cases appears to be related to the active genome of the virus, which may affect its pathogenesis. An understanding of the novel coronavirus genomic organization will help us in understanding their origi...
[ 8 ] - Facemask Risks during the COVID-19 Crisis
Introduction: With the increasing severity of the COVID-19 epidemic, wearing a mask was recommended. This recommendation seems to have created concern among the public. Wearing a mask generally reduces the risk of virus and therefore potentially saves lives. In healthy populations, wearing a mask does not appear to cause any harmful physiological changes, and the potentially life-saving benefit...
[ 9 ] - Effect of citric acid on p53 and p21 genes expression of the human colorectal Adenocarcinoma cell line
Background & Aim: Despite the advances in treatment of colorectal adenocarcinoma patients continue to have low survival. Citric acid is considered as a physiological inhibitor of enzymes involved in glycolysis pathway to remove cancer cells. The p53 and p21 gene products are involved in cell removal due to their pro-apoptotic properties. In this study, the effect of citric acid on p53 and p21 g...
[ 10 ] - Occurrence of Staphylococcus Aureus-Induced Apoptosis During Infection, Strategy for Cancer Treatment
Introduction: Despite advances in the recognition of new risk factors, prevention, diagnosis and treatment, cancer is still remains as a global health problem. Several numbers of studies have recently provided evidence that because of having pro apoptotic effects, biotoxins such as bacterial toxins, could be used as potential antitumor agents. Staphylococcus aureus, as a major human pathogen, h...
[ 11 ] - Cytotoxic effect of curcumin on viability and P21 and Bcl-2 genes expression of the human anaplastic thyroid Carcinoma cells line (SW-1736)
Background & Aim: Anaplastic thyroid carcinoma (ATC) is an uncommon malignancy of the thyroid .with poor prognosis and 2 to 6 month of survival time. The aim of this study was to explore the effect of curcumin on bioavailability and expression of p21 and Bcl-2 genes in human anaplastic thyroid carcinoma cell line (SW-1736). Methods: In this study, human anaplastic thyroid carcinoma (SW-1736) c...
[ 12 ] - A Case Report of Harlequin Ichthyosis
Harlequin ichthyosis is the most severe form of congenital ichthyoses with horny (Keratinized) and chapped thick skin throughout the body. In this disease, disruption in keratinization of epidermis results in the impaired barrier function and susceptibility of the neonate to dehydration and infection. In this article, a term male neonate with harlequin ichthyosis, born of a 29-year-old mother, ...
[ 13 ] - A Case Report of Neonatal Pemphigus vulgaris
Pemphigus vulgaris (PV) is a chronic, rare mucocutaneous autoimmune bullous diseases characterized by flaccid blisters and/or pustules, with secondary erosions of the mucous membranes / skin. Pemphigus vulgaris is threatening patient life by the formation of splits within the epidermis, accompanied by acantholysis (separation of keratinocytes from each other). In this article, a term female neo...
[ 14 ] - Cytotoxic and pro-apoptotic Effects of Spirulina Platensis Extract on PC-3 Prostate Adenocarcinoma Cell Line
Introduction: Prostate cancer is one of the most common cancers among men, with an increasing incidence and mortality rate. In the present study, cytotoxic and pro-apoptotic effects of spirulina platensis extract on PC-3 prostate adenocarcinoma cell line were investigated. Methods: In the present experimental study, the PC-3 prostatic cancer cells were treated in four experimental with 400, ...
[ 15 ] - Recombinant probiotic-Based Vaccines; Attractive vehicles for immunization via mucosal routes
Introduction: The importance of genetically modified microorganisms, including probiotics, now widely have considered as attractive vehicles for mucosal delivery of therapeutic molecules. Previous studies have indicated that mucosal administration of these molecules can effectively trigger humoral along with cellular immune responses. Therefore, development of induction of mucosal immune respon...
[ 16 ] - Bioinformatics identification of miRNA-mRNA regulatory network contributing to lung cancer invasion
Background: Over the past 15 years, significant insights have been gained into the roles of miRNAs in cancer. In various cancers, miRNAs can act as oncogenes, tumor suppressors, or control the metastasis process by modulating the expression of numerous target genes. This study is aimed at determining molecular network of miRNA-mRNA regulating lung cancer invasion, by bioinformatics approaches. ...
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