اکبری کردخیلی, وحید
. کارشناس ارشد بیوشیمی پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی مازندران، ساری، ایران
[ 1 ] - مروری بر اثرات سیلیبینین بر روی بیان miRNA های مختلف در سرطان
MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of about 60% of human genomes. Silibinin or mixture of silybin A and B is a flavonolignans that constitute 70-80% Silymarin which is considered to be its main effective ingredient. Silibinin revealed antioxidant and anti-inflammatory effects by scavenging free radicals, improving antioxidant enzymatic activities, and supp...
[ 2 ] - The protective effects of silymarin on ischemia-reperfusion injuries: A mechanistic review
Ischemia-reperfusion injuries (IRI) occur in different clinical conditions such as stroke, trauma, organ transplantation, and so on. Ischemia damages mainly arise from oxygen depletion in tissues. The lack of oxygen as the last acceptor of electron in the respiratory chain causes a decrease in ATP production and eventually leads to disruption of membrane transport, acidosis, cellular edema and ...
[ 3 ] - Effects of silibinin on hepatic warm ischemia-reperfusion injury in the rat model
Objective(s): Liver ischemia-reperfusion injuries (I/RI) are typically the main causes of liver dysfunction after various types of liver surgery especially liver transplantation. Radical components are the major causes of such direct injuries. We aimed to determine the beneficial effects of silibinin, a potent radical scavenger on liver I/RI.Materials...