محمدی, محمد حسین
علوم پزشکی شهید بهشتی
[ 1 ] - بررسی بیان ژن های 1 Beclin و 10 Atg در مسیر اتوفاژی و در مبتلایان به لوسمی لنفوبلاستی حاد
زمینه و هدف: لوسمی لنفوبلاستیک حاد (ALL) سرطانی است که اغلب، کودکان و نوجوانان را در معرض خطر قرار می‌دهد و با نسبت کمتر در بزرگ‌سالان نیز دیده می‌شود. اتوفاژی فرایند کاتابولیک برنامه ریزی شده سلول برای تخریب اندام‌ها و پروتئین های آسیب دیده است و این عمل را توسط لیزوزم ها به انجام می‌رساند. اختلال در اتوفاژی منجر به ناهنجاری‌هایی در فرآیندهای سلولی می‌شود. روش بررسی: در این مطالعه، بیان ژن‌های...
[ 2 ] - Evaluation of ATG7 and Light Chain 3 (LC3) Autophagy Genes Expression in Newly Diagnosed AML Patients
Evaluation of ATG7 and LC3 Autophagy Genes Expression in Newly Diagnosed AML patients Background and aim: Autophagy, known as cell death type II, is a housekeeping pathway that currently has been worked on in matters of tumorigenesis and leukemogenesis. Therefore, in this study expression levels of ATG7 and LC3 as two key genes are targeted in AML patients. Material and method: This...
[ 3 ] - Evaluation of ATG7 and Light Chain 3 (LC3) Autophagy Genes Expression in Newly Diagnosed AML Patients
Evaluation of ATG7 and LC3 Autophagy Genes Expression in Newly Diagnosed AML patients Background and aim: Autophagy, known as cell death type II, is a housekeeping pathway that currently has been worked on in matters of tumorigenesis and leukemogenesis. Therefore, in this study expression levels of ATG7 and LC3 as two key genes are targeted in AML patients. Material and method: This...
[ 4 ] - Proteasome Inhibition by Carfilzomib Induced Apotosis and Autophagy in a T-cell Acute Lymphoblastic Leukemia Cell Line
T-cell acute lymphoblastic leukemia is an aggressive hematologic malignancy which is usuallyassociated with unfavorable prognosis particularly in patients with refractory/relapsed disease.Therefore, development of novel therapeutic strategies is highly required for improving theoutcome of these patients. Although there are several studies evaluating the efficacy of proteasome<...
[ 5 ] - Proteasome Inhibition by Carfilzomib Induced Apotosis and Autophagy in a T-cell Acute Lymphoblastic Leukemia Cell Line
T-cell acute lymphoblastic leukemia is an aggressive hematologic malignancy which is usuallyassociated with unfavorable prognosis particularly in patients with refractory/relapsed disease.Therefore, development of novel therapeutic strategies is highly required for improving theoutcome of these patients. Although there are several studies evaluating the efficacy of proteasome<...