نظری سرنجه, فرزانه
گروه زیست‌شناسی، دانشگاه پیام‌نور
[ 1 ] - تأثیر تزریق درون هیپوکامپی گرلین بر فراموشی القاشده ناشی از مورفین با مدل یادگیری اجتنابی غیرفعال در موش بزرگ نر آزمایشگاهی
زمینه و هدف: گرلین یک هورمون پپتیدی است که از سلول‌های معده ترشح می‌شود و نقش مهمی در تنظیم متابولیسم و تعادل انرژی در بدن دارد. این هورمون از سد خونی - مغزی عبور کرده و با ورود به هیپوکامپ، فرآیند یادگیری و حافظه را تحت تأثیر قرار می‌دهد. در مطالعه حاضر، اثرات تزریق درون‌هیپوکامپی گرلین بر فراموشی القاشده ناشی از مورفین با مدل یادگیری اجتنابی غیرفعال موش بزرگ آزمایشگاهی نر بررسی گردید. روش برر...
[ 2 ] - Effect of Ghrelin on Viability, Proliferation, and Apoptosis in Human Granulosa Cells, In Vitro
Background and Objectives: Ghrelin is a peptide hormone that was initially derived from stomach and introduced as an endogenous ligand for the growth hormone secretagogue receptor. Ghrelin is fundamentally involved in regulation of nutrition and energy homeostasis in the body. It has been shown that ghrelin has an important role in fertility in women. The purpose of the present study was to ass...
[ 3 ] - The Effect of Intra-ventral Tegmental Area Injection of Ghrelin on Morphine-Induced Amnesia in Male Rats: An Experimental Study
Background and Objectives: Extensive evidence shows that morphine impairs cognitive functions. On the other hand, ghrelin is a gastrointestinal hormone that affects learning and memory process. The purpose of the current study was to evaluate the effect of intra-ventral tegmental area (VTA) injection of ghrelin on morphine-induced amnesia in male rats. Materials and Methods: In this experiment...
[ 4 ] - Involvement of Median Septum Region in Ghrelin Effects on Morphine-Induced Memory Impairment in Passive Avoidance Learning
Background and purpose: Many studies have reported the effect of morphine on memory impairment. Evidence suggests that ghrelin enhances memory consolidation. The median septum also has a major role in memory and learning mechanisms. The present study aimed at investigating the role of median septum on the effects of ghrelin in morphine-induced amnesia. Materials and methods: In this experiment...
[ 5 ] - The Effect of Intra-Medial Septum Co-Injection of Ghrelin and Nicotine on Morphine Induced Memory Impairment
Evidence indicates that medial septum nicotinic receptors regulate cognitive process. Ghrelin is a gut hormone that regulates energy homeostasis. Ghrelin also is produced in brain and known to be involved in cognitive function. The purpose of the study was to evaluate the effects of medial septal injection of ghrelin on morphine-induced memory impairment in rats. Also, the possible relationship...