Mojtaba Hedayati CH
Department of Medical Microbiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
[ 1 ] - Aptamer-based Targeted Delivery of miRNA let-7d to Gastric Cancer Cells as a Novel Anti-Tumor Therapeutic Agent
miRNAs as one of the potential therapeutic agents have been recently considered for cancer treatment. AS1411 (aptNCL) is a DNA aptamer specifically binding to nucleolin protein on the cancer cell surface with antiproliferative effect. The aim of the study was to develop a conjugate consisted of aptNCL (as targeted delivery of therapeutic agent) and miRNA let-7d (as a tumor suppressor) using two...
[ 2 ] - Aptamer-based Targeted Delivery of miRNA let-7d to Gastric Cancer Cells as a Novel Anti-Tumor Therapeutic Agent
miRNAs as one of the potential therapeutic agents have been recently considered for cancer treatment. AS1411 (aptNCL) is a DNA aptamer specifically binding to nucleolin protein on the cancer cell surface with antiproliferative effect. The aim of the study was to develop a conjugate consisted of aptNCL (as targeted delivery of therapeutic agent) and miRNA let-7d (as a tumor suppressor) using two...
[ 3 ] - Protective Effect of the Viola Spathulata Extract on NCX3 Gene Expression in an Animal Model of Cerebral Ischemia
Abstract_ Introduction: Viola plant has been used traditionally for the treatment of neurological disorders. We aimed at determining whether pretreatment with Viola spathulata extract can alleviate the severity of ischemic-reperfusion damages and it can exert its protective effects through the regulation of a sodium/calcium exchanger (NCX3) gene expression in a rat brain. Methods: Male Wistar r...
[ 4 ] - Effect of Synbiotics on Lipid Profile and Serum Levels of Gonadotropins, Insulin and Glucose in Rats with Polycystic Ovary Syndrome Induced by Lipopolysaccharide
Background: In women of childbearing age, Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder. The cause of PCOS is still unknown and several factors may be involved. Objective: This study aims to evaluate the effect of synbiotics on serum parameters such as Follicle-Stimulating Hormone (FSH), Luteinizing Hormone (LH), triglyceride, cholesterol, glucose, and insulin in rats with PC...