Elham Ahmadian
Department of Pharmacology and Toxicology, Maragheh University of Medical Sciences, Maragheh, Iran.|Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. |Students’ Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
[ 1 ] - Mechanistic approach for thioridazine-induced hepatotoxicity and potential benefits of melatonin and/or coenzyme Q10 on freshly isolated rat hepatocytes
Thioridazine (TZ) is used mainly in the treatment of schizophrenia. However, hepatotoxicity as a life-threatening adverse effect is associated with its clinical use. In this context, we examined the cytotoxic mechanisms of TZ on freshly isolated rat hepatocytes to better understanding of the pathogenesis of TZ-induced hepatotoxicity. Hepatocytes were prepared by the method of collagenase enzyme...
[ 2 ] - Mechanistic approach for thioridazine-induced hepatotoxicity and potential benefits of melatonin and/or coenzyme Q10 on freshly isolated rat hepatocytes
Thioridazine (TZ) is used mainly in the treatment of schizophrenia. However, hepatotoxicity as a life-threatening adverse effect is associated with its clinical use. In this context, we examined the cytotoxic mechanisms of TZ on freshly isolated rat hepatocytes to better understanding of the pathogenesis of TZ-induced hepatotoxicity. Hepatocytes were prepared by the method of collagenase enzyme...
[ 3 ] - The Histopathological Evaluation of the Effects of Capparis spinosa Seed Hydroalcoholic Extract on Cisplatin- induced-Nephrotoxicity in Rats
Background and Objective: Increment in cancer prevalence and subsequent need for chemotherapy leads to distinct kidney-related diseases such as acute kidney injury (AKI). Cisplatin is a common chemotherapeutic agent that has been used in many cancers; however, it can damage renal cells. Capparis spinosa is an important therapeutic plant in Persian medicine that encompasses high amounts of bioac...